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The relationship between cardiological parameters and PCR in patients with coronavirus infection: A cross-sectional study

Cardiovascular injuries induced by SARS CoV-2 have been reported repeatedly in various studies. Therefore, it is necessary to understand cardiac complications at a low cost, quickly. This study aimed to determine the relationship between cardiological parameters and polymerase chain reaction (PCR) i...

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Autores principales: Majidi, Fatemeh, Mohagheghi Dare Ranj, Abbas, Jameie, Mana, Jameie, Melika, Mansouri, Pejman, Varpaei, Hesam Aldin, Shirani, Shahin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771227/
https://www.ncbi.nlm.nih.gov/pubmed/36550863
http://dx.doi.org/10.1097/MD.0000000000031935
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author Majidi, Fatemeh
Mohagheghi Dare Ranj, Abbas
Jameie, Mana
Jameie, Melika
Mansouri, Pejman
Varpaei, Hesam Aldin
Shirani, Shahin
author_facet Majidi, Fatemeh
Mohagheghi Dare Ranj, Abbas
Jameie, Mana
Jameie, Melika
Mansouri, Pejman
Varpaei, Hesam Aldin
Shirani, Shahin
author_sort Majidi, Fatemeh
collection PubMed
description Cardiovascular injuries induced by SARS CoV-2 have been reported repeatedly in various studies. Therefore, it is necessary to understand cardiac complications at a low cost, quickly. This study aimed to determine the relationship between cardiological parameters and polymerase chain reaction (PCR) in patients with coronavirus infection. : Patients who were admitted to the emergency department due to the ongoing pandemic, all patients with similar symptoms to coronavirus disease 2019 infection were initially admitted to the respiratory emergency room and underwent subsequent evaluations to confirm or rule out SARS-COV2 infection symptoms were assessed for eligibility. Patient were categorized into 2 groups 1. Positive PCR and negative PCR groups. Binary logistic regression was performed to assess the effect of several factors on the likelihood of developing positive troponin, reduced ejection fraction (EF), and Positive brain natriuretic peptide (BNP). Among 195 patients included, 115 (58.9%) had positive PCR. Patient in the positive PCR and negative PCR were 58.04 ± 18.03 and 59.19 ± 15.38 years of age, respectively. Patients in the “positive PCR” were significantly less likely to have chronic kidney disease (6.69% vs 17.5%, P value: .022), consume calcium channel blockers (6.69% vs 18.75%, P value:0.012). At the univariable level, positive PCR was significantly associated with fewer odds for positive BNP (OR:0.46, P = .019); nevertheless, the association was no longer significant after adjusting for confounders (adjusted OR:0.56, P = .158). Unadjusted positive PCR results were not found to have a significant association with positive troponin or reduced EF. Likewise, multivariable regression revealed no association between positive PCR and positive troponin (aOR:1.28, P = .529) and reduced EF (aOR:0.65, P = .369). PCR positivity did not result in positive troponin and BNP and did not appear to decrease EF. In other words, serial troponin and BNP checks and initial echocardiography in coronavirus disease 2019 respiratory emergencies do not make significant differences in diagnostic and therapeutic management and inpatient outcomes of patients with positive or negative PCR and are not specific findings. Evidence suggests some coronavirus-induced cardiac complications will be manifested in the long term.
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spelling pubmed-97712272022-12-22 The relationship between cardiological parameters and PCR in patients with coronavirus infection: A cross-sectional study Majidi, Fatemeh Mohagheghi Dare Ranj, Abbas Jameie, Mana Jameie, Melika Mansouri, Pejman Varpaei, Hesam Aldin Shirani, Shahin Medicine (Baltimore) 3400 Cardiovascular injuries induced by SARS CoV-2 have been reported repeatedly in various studies. Therefore, it is necessary to understand cardiac complications at a low cost, quickly. This study aimed to determine the relationship between cardiological parameters and polymerase chain reaction (PCR) in patients with coronavirus infection. : Patients who were admitted to the emergency department due to the ongoing pandemic, all patients with similar symptoms to coronavirus disease 2019 infection were initially admitted to the respiratory emergency room and underwent subsequent evaluations to confirm or rule out SARS-COV2 infection symptoms were assessed for eligibility. Patient were categorized into 2 groups 1. Positive PCR and negative PCR groups. Binary logistic regression was performed to assess the effect of several factors on the likelihood of developing positive troponin, reduced ejection fraction (EF), and Positive brain natriuretic peptide (BNP). Among 195 patients included, 115 (58.9%) had positive PCR. Patient in the positive PCR and negative PCR were 58.04 ± 18.03 and 59.19 ± 15.38 years of age, respectively. Patients in the “positive PCR” were significantly less likely to have chronic kidney disease (6.69% vs 17.5%, P value: .022), consume calcium channel blockers (6.69% vs 18.75%, P value:0.012). At the univariable level, positive PCR was significantly associated with fewer odds for positive BNP (OR:0.46, P = .019); nevertheless, the association was no longer significant after adjusting for confounders (adjusted OR:0.56, P = .158). Unadjusted positive PCR results were not found to have a significant association with positive troponin or reduced EF. Likewise, multivariable regression revealed no association between positive PCR and positive troponin (aOR:1.28, P = .529) and reduced EF (aOR:0.65, P = .369). PCR positivity did not result in positive troponin and BNP and did not appear to decrease EF. In other words, serial troponin and BNP checks and initial echocardiography in coronavirus disease 2019 respiratory emergencies do not make significant differences in diagnostic and therapeutic management and inpatient outcomes of patients with positive or negative PCR and are not specific findings. Evidence suggests some coronavirus-induced cardiac complications will be manifested in the long term. Lippincott Williams & Wilkins 2022-12-16 /pmc/articles/PMC9771227/ /pubmed/36550863 http://dx.doi.org/10.1097/MD.0000000000031935 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 3400
Majidi, Fatemeh
Mohagheghi Dare Ranj, Abbas
Jameie, Mana
Jameie, Melika
Mansouri, Pejman
Varpaei, Hesam Aldin
Shirani, Shahin
The relationship between cardiological parameters and PCR in patients with coronavirus infection: A cross-sectional study
title The relationship between cardiological parameters and PCR in patients with coronavirus infection: A cross-sectional study
title_full The relationship between cardiological parameters and PCR in patients with coronavirus infection: A cross-sectional study
title_fullStr The relationship between cardiological parameters and PCR in patients with coronavirus infection: A cross-sectional study
title_full_unstemmed The relationship between cardiological parameters and PCR in patients with coronavirus infection: A cross-sectional study
title_short The relationship between cardiological parameters and PCR in patients with coronavirus infection: A cross-sectional study
title_sort relationship between cardiological parameters and pcr in patients with coronavirus infection: a cross-sectional study
topic 3400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771227/
https://www.ncbi.nlm.nih.gov/pubmed/36550863
http://dx.doi.org/10.1097/MD.0000000000031935
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