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Factors impacting medication adherence in a birth cohort at higher risk for Hepatitis C infection

Due to the high prevalence of Hepatitis C virus (HCV) infection among individuals born between 1945 and 1965, in 2012 the Centers for Disease Control and Prevention began recommending HCV screening for this birth cohort. As adherence to HCV treatment is essential for sustained virologic response, id...

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Autores principales: Philip, Timothy J, Crosby, Kimberly M, Frank-Pearce, Summer G, Wendelboe, Aaron M, Solberg, Marie, Weakley, Jennifer, Williams, Mary B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771308/
https://www.ncbi.nlm.nih.gov/pubmed/36550891
http://dx.doi.org/10.1097/MD.0000000000032354
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author Philip, Timothy J
Crosby, Kimberly M
Frank-Pearce, Summer G
Wendelboe, Aaron M
Solberg, Marie
Weakley, Jennifer
Williams, Mary B
author_facet Philip, Timothy J
Crosby, Kimberly M
Frank-Pearce, Summer G
Wendelboe, Aaron M
Solberg, Marie
Weakley, Jennifer
Williams, Mary B
author_sort Philip, Timothy J
collection PubMed
description Due to the high prevalence of Hepatitis C virus (HCV) infection among individuals born between 1945 and 1965, in 2012 the Centers for Disease Control and Prevention began recommending HCV screening for this birth cohort. As adherence to HCV treatment is essential for sustained virologic response, identifying factors influencing medication adherence is important. The validated Adherence to Refills and Medications Scale (ARMS) is used to study recent medication adherence in those with chronic disease. This cross-sectional pilot study assesses factors associated with reduced adherence, indicated by higher ARMS scores, among individuals in this birth cohort. To elucidate factors associated with medication adherence, measured by the ARMS score, among a birth cohort at higher risk for HCV to guide future treatment and improve adherence. Patients born between 1945 and 1965, accessing care at an academic family medicine clinic, were recruited between April and June 2019. Demographics, prior HCV diagnosis, HCV risk factors (prior imprisonment, tattoos, and intravenous drug use), depression assessment (Patient Health Questionnaire-9), adverse childhood experiences (ACEs), and ARMS scores were collected. Mean ARMS scores were compared using t tests and analysis of variance (α = 0.05), while multiple variable models were performed using linear regression. Women comprised 58% of participants (n = 76), 52% reported depression and 37% 4 or more ACEs. The mean ARMS score was 16.3 (SD = 3.43) and 10% reported prior diagnosis of HCV. In the final multiple variable model, ARMS scores were 2.3 points higher in those with mild depression (95% CI: 0.63, 4.04), 2.0 in those with at least 4 ACEs (95% CI: 0.55, 3.49), and 1.8 in those with tattoos (95% CI: 0.30, 3.28). ACEs and food insecurity were identified as confounding variables in those with moderate to severe depression. This study found medication adherence was related to depression, ACEs, tattoos, and food insecurity among patients in this birth cohort at higher risk for HCV.
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spelling pubmed-97713082022-12-23 Factors impacting medication adherence in a birth cohort at higher risk for Hepatitis C infection Philip, Timothy J Crosby, Kimberly M Frank-Pearce, Summer G Wendelboe, Aaron M Solberg, Marie Weakley, Jennifer Williams, Mary B Medicine (Baltimore) 6600 Due to the high prevalence of Hepatitis C virus (HCV) infection among individuals born between 1945 and 1965, in 2012 the Centers for Disease Control and Prevention began recommending HCV screening for this birth cohort. As adherence to HCV treatment is essential for sustained virologic response, identifying factors influencing medication adherence is important. The validated Adherence to Refills and Medications Scale (ARMS) is used to study recent medication adherence in those with chronic disease. This cross-sectional pilot study assesses factors associated with reduced adherence, indicated by higher ARMS scores, among individuals in this birth cohort. To elucidate factors associated with medication adherence, measured by the ARMS score, among a birth cohort at higher risk for HCV to guide future treatment and improve adherence. Patients born between 1945 and 1965, accessing care at an academic family medicine clinic, were recruited between April and June 2019. Demographics, prior HCV diagnosis, HCV risk factors (prior imprisonment, tattoos, and intravenous drug use), depression assessment (Patient Health Questionnaire-9), adverse childhood experiences (ACEs), and ARMS scores were collected. Mean ARMS scores were compared using t tests and analysis of variance (α = 0.05), while multiple variable models were performed using linear regression. Women comprised 58% of participants (n = 76), 52% reported depression and 37% 4 or more ACEs. The mean ARMS score was 16.3 (SD = 3.43) and 10% reported prior diagnosis of HCV. In the final multiple variable model, ARMS scores were 2.3 points higher in those with mild depression (95% CI: 0.63, 4.04), 2.0 in those with at least 4 ACEs (95% CI: 0.55, 3.49), and 1.8 in those with tattoos (95% CI: 0.30, 3.28). ACEs and food insecurity were identified as confounding variables in those with moderate to severe depression. This study found medication adherence was related to depression, ACEs, tattoos, and food insecurity among patients in this birth cohort at higher risk for HCV. Lippincott Williams & Wilkins 2022-12-16 /pmc/articles/PMC9771308/ /pubmed/36550891 http://dx.doi.org/10.1097/MD.0000000000032354 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 6600
Philip, Timothy J
Crosby, Kimberly M
Frank-Pearce, Summer G
Wendelboe, Aaron M
Solberg, Marie
Weakley, Jennifer
Williams, Mary B
Factors impacting medication adherence in a birth cohort at higher risk for Hepatitis C infection
title Factors impacting medication adherence in a birth cohort at higher risk for Hepatitis C infection
title_full Factors impacting medication adherence in a birth cohort at higher risk for Hepatitis C infection
title_fullStr Factors impacting medication adherence in a birth cohort at higher risk for Hepatitis C infection
title_full_unstemmed Factors impacting medication adherence in a birth cohort at higher risk for Hepatitis C infection
title_short Factors impacting medication adherence in a birth cohort at higher risk for Hepatitis C infection
title_sort factors impacting medication adherence in a birth cohort at higher risk for hepatitis c infection
topic 6600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771308/
https://www.ncbi.nlm.nih.gov/pubmed/36550891
http://dx.doi.org/10.1097/MD.0000000000032354
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