Senataxin and RNase H2 act redundantly to suppress genome instability during class switch recombination

Class switch recombination generates distinct antibody isotypes critical to a robust adaptive immune system, and defects are associated with autoimmune disorders and lymphomagenesis. Transcription is required during class switch recombination to recruit the cytidine deaminase AID—an essential step f...

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Detalles Bibliográficos
Autores principales: Zhao, Hongchang, Hartono, Stella R, de Vera, Kirtney Mae Flores, Yu, Zheyuan, Satchi, Krishni, Zhao, Tracy, Sciammas, Roger, Sanz, Lionel, Chédin, Frédéric, Barlow, Jacqueline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771370/
https://www.ncbi.nlm.nih.gov/pubmed/36542058
http://dx.doi.org/10.7554/eLife.78917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771370/
https://www.ncbi.nlm.nih.gov/pubmed/36542058
http://dx.doi.org/10.7554/eLife.78917

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