Comparison of EMLA Cream versus Lidocaine Injection for Lumbar Puncture Pain Control in Pediatric Oncology Patients

Background  Subcutaneous lidocaine injection and topical EMLA cream are both used to control lumbar puncture (LP) pain; however, local analgesia usage is not standardized. Methods  We conducted a prospective, single-blinded, randomized-controlled crossover trial comparing the two modalities in reduc...

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Autores principales: Merry-Sperry, Andrea D., Alqudah, Elham, Magner, Alexa, Thompson, Stephanie, Smith, Pamela, Meyer, Ashley, Badawi, Mohamad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771623/
https://www.ncbi.nlm.nih.gov/pubmed/36570427
http://dx.doi.org/10.1055/s-0042-1758389
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author Merry-Sperry, Andrea D.
Alqudah, Elham
Magner, Alexa
Thompson, Stephanie
Smith, Pamela
Meyer, Ashley
Badawi, Mohamad
author_facet Merry-Sperry, Andrea D.
Alqudah, Elham
Magner, Alexa
Thompson, Stephanie
Smith, Pamela
Meyer, Ashley
Badawi, Mohamad
author_sort Merry-Sperry, Andrea D.
collection PubMed
description Background  Subcutaneous lidocaine injection and topical EMLA cream are both used to control lumbar puncture (LP) pain; however, local analgesia usage is not standardized. Methods  We conducted a prospective, single-blinded, randomized-controlled crossover trial comparing the two modalities in reducing LP pain. Pediatric patients requiring serial LPs were randomly assigned to receive EMLA cream or lidocaine injection prior to LP. On the subsequent LP, analgesia was defaulted to the other agent. Pain was assessed using the Wong-Baker FACES Pain Rating Scale pre-procedure: 30 to 60 minutes post-LP, and 24 hours post-procedure. Results  Ten patients were included in the analysis (median age: 5.5 years). Pain ratings at 1 and 24 hours post-LP did not differ between the two strategies ( p  = 0.79). No adverse local reactions were reported for either agent. Conclusion  Accordingly, both lidocaine and EMLA cream provided effective LP pain control.
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spelling pubmed-97716232022-12-22 Comparison of EMLA Cream versus Lidocaine Injection for Lumbar Puncture Pain Control in Pediatric Oncology Patients Merry-Sperry, Andrea D. Alqudah, Elham Magner, Alexa Thompson, Stephanie Smith, Pamela Meyer, Ashley Badawi, Mohamad Avicenna J Med Background  Subcutaneous lidocaine injection and topical EMLA cream are both used to control lumbar puncture (LP) pain; however, local analgesia usage is not standardized. Methods  We conducted a prospective, single-blinded, randomized-controlled crossover trial comparing the two modalities in reducing LP pain. Pediatric patients requiring serial LPs were randomly assigned to receive EMLA cream or lidocaine injection prior to LP. On the subsequent LP, analgesia was defaulted to the other agent. Pain was assessed using the Wong-Baker FACES Pain Rating Scale pre-procedure: 30 to 60 minutes post-LP, and 24 hours post-procedure. Results  Ten patients were included in the analysis (median age: 5.5 years). Pain ratings at 1 and 24 hours post-LP did not differ between the two strategies ( p  = 0.79). No adverse local reactions were reported for either agent. Conclusion  Accordingly, both lidocaine and EMLA cream provided effective LP pain control. Thieme Medical and Scientific Publishers Pvt. Ltd. 2022-12-21 /pmc/articles/PMC9771623/ /pubmed/36570427 http://dx.doi.org/10.1055/s-0042-1758389 Text en Syrian American Medical Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Merry-Sperry, Andrea D.
Alqudah, Elham
Magner, Alexa
Thompson, Stephanie
Smith, Pamela
Meyer, Ashley
Badawi, Mohamad
Comparison of EMLA Cream versus Lidocaine Injection for Lumbar Puncture Pain Control in Pediatric Oncology Patients
title Comparison of EMLA Cream versus Lidocaine Injection for Lumbar Puncture Pain Control in Pediatric Oncology Patients
title_full Comparison of EMLA Cream versus Lidocaine Injection for Lumbar Puncture Pain Control in Pediatric Oncology Patients
title_fullStr Comparison of EMLA Cream versus Lidocaine Injection for Lumbar Puncture Pain Control in Pediatric Oncology Patients
title_full_unstemmed Comparison of EMLA Cream versus Lidocaine Injection for Lumbar Puncture Pain Control in Pediatric Oncology Patients
title_short Comparison of EMLA Cream versus Lidocaine Injection for Lumbar Puncture Pain Control in Pediatric Oncology Patients
title_sort comparison of emla cream versus lidocaine injection for lumbar puncture pain control in pediatric oncology patients
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771623/
https://www.ncbi.nlm.nih.gov/pubmed/36570427
http://dx.doi.org/10.1055/s-0042-1758389
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