Spiking SARS-CoV-2 antiviral immunity in the respiratory tract

The COVID-19 pandemic enabled the successful launch of mRNA-based vaccines that, when given intramuscularly, elicit spike-specific antibodies and prevent severe disease, but do not promote mucosal immunity. New data suggest how to boost systemic immunity and elicit pulmonary immunity in a way that m...

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Detalles Bibliográficos
Autores principales: Silva-Sanchez, Aaron, Randall, Troy D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771740/
https://www.ncbi.nlm.nih.gov/pubmed/36593157
http://dx.doi.org/10.1016/j.it.2022.12.007
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author Silva-Sanchez, Aaron
Randall, Troy D.
author_facet Silva-Sanchez, Aaron
Randall, Troy D.
author_sort Silva-Sanchez, Aaron
collection PubMed
description The COVID-19 pandemic enabled the successful launch of mRNA-based vaccines that, when given intramuscularly, elicit spike-specific antibodies and prevent severe disease, but do not promote mucosal immunity. New data suggest how to boost systemic immunity and elicit pulmonary immunity in a way that more effectively controls infection and impairs transmission.
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spelling pubmed-97717402022-12-22 Spiking SARS-CoV-2 antiviral immunity in the respiratory tract Silva-Sanchez, Aaron Randall, Troy D. Trends Immunol Spotlight The COVID-19 pandemic enabled the successful launch of mRNA-based vaccines that, when given intramuscularly, elicit spike-specific antibodies and prevent severe disease, but do not promote mucosal immunity. New data suggest how to boost systemic immunity and elicit pulmonary immunity in a way that more effectively controls infection and impairs transmission. Elsevier Ltd. 2023-02 2022-12-22 /pmc/articles/PMC9771740/ /pubmed/36593157 http://dx.doi.org/10.1016/j.it.2022.12.007 Text en © 2022 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Spotlight
Silva-Sanchez, Aaron
Randall, Troy D.
Spiking SARS-CoV-2 antiviral immunity in the respiratory tract
title Spiking SARS-CoV-2 antiviral immunity in the respiratory tract
title_full Spiking SARS-CoV-2 antiviral immunity in the respiratory tract
title_fullStr Spiking SARS-CoV-2 antiviral immunity in the respiratory tract
title_full_unstemmed Spiking SARS-CoV-2 antiviral immunity in the respiratory tract
title_short Spiking SARS-CoV-2 antiviral immunity in the respiratory tract
title_sort spiking sars-cov-2 antiviral immunity in the respiratory tract
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771740/
https://www.ncbi.nlm.nih.gov/pubmed/36593157
http://dx.doi.org/10.1016/j.it.2022.12.007
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