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Nanomaterials meet surface-enhanced Raman scattering towards enhanced clinical diagnosis: a review

Surface-enhanced Raman scattering (SERS) is a very promising tool for the direct detection of biomarkers for the diagnosis of i.e., cancer and pathogens. Yet, current SERS strategies are hampered by non-specific interactions with co-existing substances in the biological matrices and the difficulties...

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Autores principales: Yuan, Kaisong, Jurado-Sánchez, Beatriz, Escarpa, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771791/
https://www.ncbi.nlm.nih.gov/pubmed/36544151
http://dx.doi.org/10.1186/s12951-022-01711-3
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author Yuan, Kaisong
Jurado-Sánchez, Beatriz
Escarpa, Alberto
author_facet Yuan, Kaisong
Jurado-Sánchez, Beatriz
Escarpa, Alberto
author_sort Yuan, Kaisong
collection PubMed
description Surface-enhanced Raman scattering (SERS) is a very promising tool for the direct detection of biomarkers for the diagnosis of i.e., cancer and pathogens. Yet, current SERS strategies are hampered by non-specific interactions with co-existing substances in the biological matrices and the difficulties of obtaining molecular fingerprint information from the complex vibrational spectrum. Raman signal enhancement is necessary, along with convenient surface modification and machine-based learning to address the former issues. This review aims to describe recent advances and prospects in SERS-based approaches for cancer and pathogens diagnosis. First, direct SERS strategies for key biomarker sensing, including the use of substrates such as plasmonic, semiconductor structures, and 3D order nanostructures for signal enhancement will be discussed. Secondly, we will illustrate recent advances for indirect diagnosis using active nanomaterials, Raman reporters, and specific capture elements as SERS tags. Thirdly, critical challenges for translating the potential of the SERS sensing techniques into clinical applications via machine learning and portable instrumentation will be described. The unique nature and integrated sensing capabilities of SERS provide great promise for early cancer diagnosis or fast pathogens detection, reducing sanitary costs but most importantly allowing disease prevention and decreasing mortality rates.
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spelling pubmed-97717912022-12-22 Nanomaterials meet surface-enhanced Raman scattering towards enhanced clinical diagnosis: a review Yuan, Kaisong Jurado-Sánchez, Beatriz Escarpa, Alberto J Nanobiotechnology Review Surface-enhanced Raman scattering (SERS) is a very promising tool for the direct detection of biomarkers for the diagnosis of i.e., cancer and pathogens. Yet, current SERS strategies are hampered by non-specific interactions with co-existing substances in the biological matrices and the difficulties of obtaining molecular fingerprint information from the complex vibrational spectrum. Raman signal enhancement is necessary, along with convenient surface modification and machine-based learning to address the former issues. This review aims to describe recent advances and prospects in SERS-based approaches for cancer and pathogens diagnosis. First, direct SERS strategies for key biomarker sensing, including the use of substrates such as plasmonic, semiconductor structures, and 3D order nanostructures for signal enhancement will be discussed. Secondly, we will illustrate recent advances for indirect diagnosis using active nanomaterials, Raman reporters, and specific capture elements as SERS tags. Thirdly, critical challenges for translating the potential of the SERS sensing techniques into clinical applications via machine learning and portable instrumentation will be described. The unique nature and integrated sensing capabilities of SERS provide great promise for early cancer diagnosis or fast pathogens detection, reducing sanitary costs but most importantly allowing disease prevention and decreasing mortality rates. BioMed Central 2022-12-22 /pmc/articles/PMC9771791/ /pubmed/36544151 http://dx.doi.org/10.1186/s12951-022-01711-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Yuan, Kaisong
Jurado-Sánchez, Beatriz
Escarpa, Alberto
Nanomaterials meet surface-enhanced Raman scattering towards enhanced clinical diagnosis: a review
title Nanomaterials meet surface-enhanced Raman scattering towards enhanced clinical diagnosis: a review
title_full Nanomaterials meet surface-enhanced Raman scattering towards enhanced clinical diagnosis: a review
title_fullStr Nanomaterials meet surface-enhanced Raman scattering towards enhanced clinical diagnosis: a review
title_full_unstemmed Nanomaterials meet surface-enhanced Raman scattering towards enhanced clinical diagnosis: a review
title_short Nanomaterials meet surface-enhanced Raman scattering towards enhanced clinical diagnosis: a review
title_sort nanomaterials meet surface-enhanced raman scattering towards enhanced clinical diagnosis: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771791/
https://www.ncbi.nlm.nih.gov/pubmed/36544151
http://dx.doi.org/10.1186/s12951-022-01711-3
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