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Evaluation of kidney dysfunction in childhood cancer survivors

BACKGROUND: The major increase in the survival rate among children with cancer is due to improvement in the diagnosis and treatment. Despite this increase, childhood cancer survivors (CCS) are at high risk of developing late complications such as nephrotoxicity due to chemotherapy. So, we aimed to d...

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Autores principales: Mahmoud, Asmaa Abdel Sameea, Elsalam, Heba Badawy Abd, El-Deeb, Sara Mahmoud, Zanaty, Fouad Mohamed, Aboelghar, Hesham Mohamed, Elharoun, Mohamed Shokry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771802/
https://www.ncbi.nlm.nih.gov/pubmed/35338352
http://dx.doi.org/10.1038/s41390-022-02015-w
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author Mahmoud, Asmaa Abdel Sameea
Elsalam, Heba Badawy Abd
El-Deeb, Sara Mahmoud
Zanaty, Fouad Mohamed
Aboelghar, Hesham Mohamed
Elharoun, Mohamed Shokry
author_facet Mahmoud, Asmaa Abdel Sameea
Elsalam, Heba Badawy Abd
El-Deeb, Sara Mahmoud
Zanaty, Fouad Mohamed
Aboelghar, Hesham Mohamed
Elharoun, Mohamed Shokry
author_sort Mahmoud, Asmaa Abdel Sameea
collection PubMed
description BACKGROUND: The major increase in the survival rate among children with cancer is due to improvement in the diagnosis and treatment. Despite this increase, childhood cancer survivors (CCS) are at high risk of developing late complications such as nephrotoxicity due to chemotherapy. So, we aimed to detect early subclinical kidney dysfunction among CCS. METHODS: This cross-sectional study was implemented on 52 survivors of childhood cancer recruited from Pediatric Oncology Unit, Menoufia University. Laboratory evaluations for each participant, including complete blood count, serum urea, creatinine, urinary protein, urinary calcium, uric acid, and serum cystatin C and urinary Neutrophil Gelatinase Associated Lipocalin (UrNGAL) by ELISA were obtained. RESULTS: Estimated GFR was decreased in 23.1% of cases, with elevated serum cystatin C, UrNGAL and UrNGAL/Cr. There was a significant increase of Uprotein/Cr, UCa/Cr, UACR (p = 0.02), UrNGAL and UrNGAL/Cr (P < 0.001) in patients with tubular dysfunction compared without tubular dysfunction. There was a significant difference between two groups regarding cisplatin (P = 0.03) and high-dose methotrexate chemotherapy (p = 0.04). The AUCs for detecting kidney tubular dysfunction by UrNGAL and UrNGAL/Cr were 0.807 and 0.747. CONCLUSION: A significant tubular dysfunction among childhood cancer survivors receiving chemotherapy as cisplatin and high-dose methotrexate. IMPACT: Detection of kidney dysfunction mainly tubular in childhood cancer survivors after finishing chemotherapy. Urinary NGAL is a good predictor for detection of tubular dysfunction in childhood cancer survivors after finishing chemotherapy.
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spelling pubmed-97718022022-12-23 Evaluation of kidney dysfunction in childhood cancer survivors Mahmoud, Asmaa Abdel Sameea Elsalam, Heba Badawy Abd El-Deeb, Sara Mahmoud Zanaty, Fouad Mohamed Aboelghar, Hesham Mohamed Elharoun, Mohamed Shokry Pediatr Res Clinical Research Article BACKGROUND: The major increase in the survival rate among children with cancer is due to improvement in the diagnosis and treatment. Despite this increase, childhood cancer survivors (CCS) are at high risk of developing late complications such as nephrotoxicity due to chemotherapy. So, we aimed to detect early subclinical kidney dysfunction among CCS. METHODS: This cross-sectional study was implemented on 52 survivors of childhood cancer recruited from Pediatric Oncology Unit, Menoufia University. Laboratory evaluations for each participant, including complete blood count, serum urea, creatinine, urinary protein, urinary calcium, uric acid, and serum cystatin C and urinary Neutrophil Gelatinase Associated Lipocalin (UrNGAL) by ELISA were obtained. RESULTS: Estimated GFR was decreased in 23.1% of cases, with elevated serum cystatin C, UrNGAL and UrNGAL/Cr. There was a significant increase of Uprotein/Cr, UCa/Cr, UACR (p = 0.02), UrNGAL and UrNGAL/Cr (P < 0.001) in patients with tubular dysfunction compared without tubular dysfunction. There was a significant difference between two groups regarding cisplatin (P = 0.03) and high-dose methotrexate chemotherapy (p = 0.04). The AUCs for detecting kidney tubular dysfunction by UrNGAL and UrNGAL/Cr were 0.807 and 0.747. CONCLUSION: A significant tubular dysfunction among childhood cancer survivors receiving chemotherapy as cisplatin and high-dose methotrexate. IMPACT: Detection of kidney dysfunction mainly tubular in childhood cancer survivors after finishing chemotherapy. Urinary NGAL is a good predictor for detection of tubular dysfunction in childhood cancer survivors after finishing chemotherapy. Nature Publishing Group US 2022-03-25 2022 /pmc/articles/PMC9771802/ /pubmed/35338352 http://dx.doi.org/10.1038/s41390-022-02015-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Clinical Research Article
Mahmoud, Asmaa Abdel Sameea
Elsalam, Heba Badawy Abd
El-Deeb, Sara Mahmoud
Zanaty, Fouad Mohamed
Aboelghar, Hesham Mohamed
Elharoun, Mohamed Shokry
Evaluation of kidney dysfunction in childhood cancer survivors
title Evaluation of kidney dysfunction in childhood cancer survivors
title_full Evaluation of kidney dysfunction in childhood cancer survivors
title_fullStr Evaluation of kidney dysfunction in childhood cancer survivors
title_full_unstemmed Evaluation of kidney dysfunction in childhood cancer survivors
title_short Evaluation of kidney dysfunction in childhood cancer survivors
title_sort evaluation of kidney dysfunction in childhood cancer survivors
topic Clinical Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771802/
https://www.ncbi.nlm.nih.gov/pubmed/35338352
http://dx.doi.org/10.1038/s41390-022-02015-w
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