Deep learning models for predicting RNA degradation via dual crowdsourcing

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Medicines based on messenger RNA (mRNA) hold immense potential, as evidenced by their rapid deployment as COVID-19 vaccines. However, worldwide distribution of mRNA molecules has been limited by their thermostability, which is fundamentally limited by the intrinsic instability of RNA molecules to a...

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Detalles Bibliográficos
Autores principales: Wayment-Steele, Hannah K., Kladwang, Wipapat, Watkins, Andrew M., Kim, Do Soon, Tunguz, Bojan, Reade, Walter, Demkin, Maggie, Romano, Jonathan, Wellington-Oguri, Roger, Nicol, John J., Gao, Jiayang, Onodera, Kazuki, Fujikawa, Kazuki, Mao, Hanfei, Vandewiele, Gilles, Tinti, Michele, Steenwinckel, Bram, Ito, Takuya, Noumi, Taiga, He, Shujun, Ishi, Keiichiro, Lee, Youhan, Öztürk, Fatih, Chiu, King Yuen, Öztürk, Emin, Amer, Karim, Fares, Mohamed, Das, Rhiju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771809/
https://www.ncbi.nlm.nih.gov/pubmed/36567960
http://dx.doi.org/10.1038/s42256-022-00571-8
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