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Genetic diversity fuels gene discovery for tobacco and alcohol use
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury(1–4). These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of Eur...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771818/ https://www.ncbi.nlm.nih.gov/pubmed/36477530 http://dx.doi.org/10.1038/s41586-022-05477-4 |
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author | Saunders, Gretchen R. B. Wang, Xingyan Chen, Fang Jang, Seon-Kyeong Liu, Mengzhen Wang, Chen Gao, Shuang Jiang, Yu Khunsriraksakul, Chachrit Otto, Jacqueline M. Addison, Clifton Akiyama, Masato Albert, Christine M. Aliev, Fazil Alonso, Alvaro Arnett, Donna K. Ashley-Koch, Allison E. Ashrani, Aneel A. Barnes, Kathleen C. Barr, R. Graham Bartz, Traci M. Becker, Diane M. Bielak, Lawrence F. Benjamin, Emelia J. Bis, Joshua C. Bjornsdottir, Gyda Blangero, John Bleecker, Eugene R. Boardman, Jason D. Boerwinkle, Eric Boomsma, Dorret I. Boorgula, Meher Preethi Bowden, Donald W. Brody, Jennifer A. Cade, Brian E. Chasman, Daniel I. Chavan, Sameer Chen, Yii-Der Ida Chen, Zhengming Cheng, Iona Cho, Michael H. Choquet, Hélène Cole, John W. Cornelis, Marilyn C. Cucca, Francesco Curran, Joanne E. de Andrade, Mariza Dick, Danielle M. Docherty, Anna R. Duggirala, Ravindranath Eaton, Charles B. Ehringer, Marissa A. Esko, Tõnu Faul, Jessica D. Fernandes Silva, Lilian Fiorillo, Edoardo Fornage, Myriam Freedman, Barry I. Gabrielsen, Maiken E. Garrett, Melanie E. Gharib, Sina A. Gieger, Christian Gillespie, Nathan Glahn, David C. Gordon, Scott D. Gu, Charles C. Gu, Dongfeng Gudbjartsson, Daniel F. Guo, Xiuqing Haessler, Jeffrey Hall, Michael E. Haller, Toomas Harris, Kathleen Mullan He, Jiang Herd, Pamela Hewitt, John K. Hickie, Ian Hidalgo, Bertha Hokanson, John E. Hopfer, Christian Hottenga, JoukeJan Hou, Lifang Huang, Hongyan Hung, Yi-Jen Hunter, David J. Hveem, Kristian Hwang, Shih-Jen Hwu, Chii-Min Iacono, William Irvin, Marguerite R. Jee, Yon Ho Johnson, Eric O. Joo, Yoonjung Y. Jorgenson, Eric Justice, Anne E. Kamatani, Yoichiro Kaplan, Robert C. Kaprio, Jaakko Kardia, Sharon L. R. Keller, Matthew C. Kelly, Tanika N. Kooperberg, Charles Korhonen, Tellervo Kraft, Peter Krauter, Kenneth Kuusisto, Johanna Laakso, Markku Lasky-Su, Jessica Lee, Wen-Jane Lee, James J. Levy, Daniel Li, Liming Li, Kevin Li, Yuqing Lin, Kuang Lind, Penelope A. Liu, Chunyu Lloyd-Jones, Donald M. Lutz, Sharon M. Ma, Jiantao Mägi, Reedik Manichaikul, Ani Martin, Nicholas G. Mathur, Ravi Matoba, Nana McArdle, Patrick F. McGue, Matt McQueen, Matthew B. Medland, Sarah E. Metspalu, Andres Meyers, Deborah A. Millwood, Iona Y. Mitchell, Braxton D. Mohlke, Karen L. Moll, Matthew Montasser, May E. Morrison, Alanna C. Mulas, Antonella Nielsen, Jonas B. North, Kari E. Oelsner, Elizabeth C. Okada, Yukinori Orrù, Valeria Palmer, Nicholette D. Palviainen, Teemu Pandit, Anita Park, S. Lani Peters, Ulrike Peters, Annette Peyser, Patricia A. Polderman, Tinca J. C. Rafaels, Nicholas Redline, Susan Reed, Robert M. Reiner, Alex P. Rice, John P. Rich, Stephen S. Richmond, Nicole E. Roan, Carol Rotter, Jerome I. Rueschman, Michael N. Runarsdottir, Valgerdur Saccone, Nancy L. Schwartz, David A. Shadyab, Aladdin H. Shi, Jingchunzi Shringarpure, Suyash S. Sicinski, Kamil Skogholt, Anne Heidi Smith, Jennifer A. Smith, Nicholas L. Sotoodehnia, Nona Stallings, Michael C. Stefansson, Hreinn Stefansson, Kari Stitzel, Jerry A. Sun, Xiao Syed, Moin Tal-Singer, Ruth Taylor, Amy E. Taylor, Kent D. Telen, Marilyn J. Thai, Khanh K. Tiwari, Hemant Turman, Constance Tyrfingsson, Thorarinn Wall, Tamara L. Walters, Robin G. Weir, David R. Weiss, Scott T. White, Wendy B. Whitfield, John B. Wiggins, Kerri L. Willemsen, Gonneke Willer, Cristen J. Winsvold, Bendik S. Xu, Huichun Yanek, Lisa R. Yin, Jie Young, Kristin L. Young, Kendra A. Yu, Bing Zhao, Wei Zhou, Wei Zöllner, Sebastian Zuccolo, Luisa Batini, Chiara Bergen, Andrew W. Bierut, Laura J. David, Sean P. Gagliano Taliun, Sarah A. Hancock, Dana B. Jiang, Bibo Munafò, Marcus R. Thorgeirsson, Thorgeir E. Liu, Dajiang J. Vrieze, Scott |
author_facet | Saunders, Gretchen R. B. Wang, Xingyan Chen, Fang Jang, Seon-Kyeong Liu, Mengzhen Wang, Chen Gao, Shuang Jiang, Yu Khunsriraksakul, Chachrit Otto, Jacqueline M. Addison, Clifton Akiyama, Masato Albert, Christine M. Aliev, Fazil Alonso, Alvaro Arnett, Donna K. Ashley-Koch, Allison E. Ashrani, Aneel A. Barnes, Kathleen C. Barr, R. Graham Bartz, Traci M. Becker, Diane M. Bielak, Lawrence F. Benjamin, Emelia J. Bis, Joshua C. Bjornsdottir, Gyda Blangero, John Bleecker, Eugene R. Boardman, Jason D. Boerwinkle, Eric Boomsma, Dorret I. Boorgula, Meher Preethi Bowden, Donald W. Brody, Jennifer A. Cade, Brian E. Chasman, Daniel I. Chavan, Sameer Chen, Yii-Der Ida Chen, Zhengming Cheng, Iona Cho, Michael H. Choquet, Hélène Cole, John W. Cornelis, Marilyn C. Cucca, Francesco Curran, Joanne E. de Andrade, Mariza Dick, Danielle M. Docherty, Anna R. Duggirala, Ravindranath Eaton, Charles B. Ehringer, Marissa A. Esko, Tõnu Faul, Jessica D. Fernandes Silva, Lilian Fiorillo, Edoardo Fornage, Myriam Freedman, Barry I. Gabrielsen, Maiken E. Garrett, Melanie E. Gharib, Sina A. Gieger, Christian Gillespie, Nathan Glahn, David C. Gordon, Scott D. Gu, Charles C. Gu, Dongfeng Gudbjartsson, Daniel F. Guo, Xiuqing Haessler, Jeffrey Hall, Michael E. Haller, Toomas Harris, Kathleen Mullan He, Jiang Herd, Pamela Hewitt, John K. Hickie, Ian Hidalgo, Bertha Hokanson, John E. Hopfer, Christian Hottenga, JoukeJan Hou, Lifang Huang, Hongyan Hung, Yi-Jen Hunter, David J. Hveem, Kristian Hwang, Shih-Jen Hwu, Chii-Min Iacono, William Irvin, Marguerite R. Jee, Yon Ho Johnson, Eric O. Joo, Yoonjung Y. Jorgenson, Eric Justice, Anne E. Kamatani, Yoichiro Kaplan, Robert C. Kaprio, Jaakko Kardia, Sharon L. R. Keller, Matthew C. Kelly, Tanika N. Kooperberg, Charles Korhonen, Tellervo Kraft, Peter Krauter, Kenneth Kuusisto, Johanna Laakso, Markku Lasky-Su, Jessica Lee, Wen-Jane Lee, James J. Levy, Daniel Li, Liming Li, Kevin Li, Yuqing Lin, Kuang Lind, Penelope A. Liu, Chunyu Lloyd-Jones, Donald M. Lutz, Sharon M. Ma, Jiantao Mägi, Reedik Manichaikul, Ani Martin, Nicholas G. Mathur, Ravi Matoba, Nana McArdle, Patrick F. McGue, Matt McQueen, Matthew B. Medland, Sarah E. Metspalu, Andres Meyers, Deborah A. Millwood, Iona Y. Mitchell, Braxton D. Mohlke, Karen L. Moll, Matthew Montasser, May E. Morrison, Alanna C. Mulas, Antonella Nielsen, Jonas B. North, Kari E. Oelsner, Elizabeth C. Okada, Yukinori Orrù, Valeria Palmer, Nicholette D. Palviainen, Teemu Pandit, Anita Park, S. Lani Peters, Ulrike Peters, Annette Peyser, Patricia A. Polderman, Tinca J. C. Rafaels, Nicholas Redline, Susan Reed, Robert M. Reiner, Alex P. Rice, John P. Rich, Stephen S. Richmond, Nicole E. Roan, Carol Rotter, Jerome I. Rueschman, Michael N. Runarsdottir, Valgerdur Saccone, Nancy L. Schwartz, David A. Shadyab, Aladdin H. Shi, Jingchunzi Shringarpure, Suyash S. Sicinski, Kamil Skogholt, Anne Heidi Smith, Jennifer A. Smith, Nicholas L. Sotoodehnia, Nona Stallings, Michael C. Stefansson, Hreinn Stefansson, Kari Stitzel, Jerry A. Sun, Xiao Syed, Moin Tal-Singer, Ruth Taylor, Amy E. Taylor, Kent D. Telen, Marilyn J. Thai, Khanh K. Tiwari, Hemant Turman, Constance Tyrfingsson, Thorarinn Wall, Tamara L. Walters, Robin G. Weir, David R. Weiss, Scott T. White, Wendy B. Whitfield, John B. Wiggins, Kerri L. Willemsen, Gonneke Willer, Cristen J. Winsvold, Bendik S. Xu, Huichun Yanek, Lisa R. Yin, Jie Young, Kristin L. Young, Kendra A. Yu, Bing Zhao, Wei Zhou, Wei Zöllner, Sebastian Zuccolo, Luisa Batini, Chiara Bergen, Andrew W. Bierut, Laura J. David, Sean P. Gagliano Taliun, Sarah A. Hancock, Dana B. Jiang, Bibo Munafò, Marcus R. Thorgeirsson, Thorgeir E. Liu, Dajiang J. Vrieze, Scott |
author_sort | Saunders, Gretchen R. B. |
collection | PubMed |
description | Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury(1–4). These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries(5). Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in sample size and genetic diversity improved locus identification and fine-mapping resolution, and that a large majority of the 3,823 associated variants (from 2,143 loci) showed consistent effect sizes across ancestry dimensions. However, polygenic risk scores developed in one ancestry performed poorly in others, highlighting the continued need to increase sample sizes of diverse ancestries to realize any potential benefit of polygenic prediction. |
format | Online Article Text |
id | pubmed-9771818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-97718182022-12-23 Genetic diversity fuels gene discovery for tobacco and alcohol use Saunders, Gretchen R. B. Wang, Xingyan Chen, Fang Jang, Seon-Kyeong Liu, Mengzhen Wang, Chen Gao, Shuang Jiang, Yu Khunsriraksakul, Chachrit Otto, Jacqueline M. Addison, Clifton Akiyama, Masato Albert, Christine M. Aliev, Fazil Alonso, Alvaro Arnett, Donna K. Ashley-Koch, Allison E. Ashrani, Aneel A. Barnes, Kathleen C. Barr, R. Graham Bartz, Traci M. Becker, Diane M. Bielak, Lawrence F. Benjamin, Emelia J. Bis, Joshua C. Bjornsdottir, Gyda Blangero, John Bleecker, Eugene R. Boardman, Jason D. Boerwinkle, Eric Boomsma, Dorret I. Boorgula, Meher Preethi Bowden, Donald W. Brody, Jennifer A. Cade, Brian E. Chasman, Daniel I. Chavan, Sameer Chen, Yii-Der Ida Chen, Zhengming Cheng, Iona Cho, Michael H. Choquet, Hélène Cole, John W. Cornelis, Marilyn C. Cucca, Francesco Curran, Joanne E. de Andrade, Mariza Dick, Danielle M. Docherty, Anna R. Duggirala, Ravindranath Eaton, Charles B. Ehringer, Marissa A. Esko, Tõnu Faul, Jessica D. Fernandes Silva, Lilian Fiorillo, Edoardo Fornage, Myriam Freedman, Barry I. Gabrielsen, Maiken E. Garrett, Melanie E. Gharib, Sina A. Gieger, Christian Gillespie, Nathan Glahn, David C. Gordon, Scott D. Gu, Charles C. Gu, Dongfeng Gudbjartsson, Daniel F. Guo, Xiuqing Haessler, Jeffrey Hall, Michael E. Haller, Toomas Harris, Kathleen Mullan He, Jiang Herd, Pamela Hewitt, John K. Hickie, Ian Hidalgo, Bertha Hokanson, John E. Hopfer, Christian Hottenga, JoukeJan Hou, Lifang Huang, Hongyan Hung, Yi-Jen Hunter, David J. Hveem, Kristian Hwang, Shih-Jen Hwu, Chii-Min Iacono, William Irvin, Marguerite R. Jee, Yon Ho Johnson, Eric O. Joo, Yoonjung Y. Jorgenson, Eric Justice, Anne E. Kamatani, Yoichiro Kaplan, Robert C. Kaprio, Jaakko Kardia, Sharon L. R. Keller, Matthew C. Kelly, Tanika N. Kooperberg, Charles Korhonen, Tellervo Kraft, Peter Krauter, Kenneth Kuusisto, Johanna Laakso, Markku Lasky-Su, Jessica Lee, Wen-Jane Lee, James J. Levy, Daniel Li, Liming Li, Kevin Li, Yuqing Lin, Kuang Lind, Penelope A. Liu, Chunyu Lloyd-Jones, Donald M. Lutz, Sharon M. Ma, Jiantao Mägi, Reedik Manichaikul, Ani Martin, Nicholas G. Mathur, Ravi Matoba, Nana McArdle, Patrick F. McGue, Matt McQueen, Matthew B. Medland, Sarah E. Metspalu, Andres Meyers, Deborah A. Millwood, Iona Y. Mitchell, Braxton D. Mohlke, Karen L. Moll, Matthew Montasser, May E. Morrison, Alanna C. Mulas, Antonella Nielsen, Jonas B. North, Kari E. Oelsner, Elizabeth C. Okada, Yukinori Orrù, Valeria Palmer, Nicholette D. Palviainen, Teemu Pandit, Anita Park, S. Lani Peters, Ulrike Peters, Annette Peyser, Patricia A. Polderman, Tinca J. C. Rafaels, Nicholas Redline, Susan Reed, Robert M. Reiner, Alex P. Rice, John P. Rich, Stephen S. Richmond, Nicole E. Roan, Carol Rotter, Jerome I. Rueschman, Michael N. Runarsdottir, Valgerdur Saccone, Nancy L. Schwartz, David A. Shadyab, Aladdin H. Shi, Jingchunzi Shringarpure, Suyash S. Sicinski, Kamil Skogholt, Anne Heidi Smith, Jennifer A. Smith, Nicholas L. Sotoodehnia, Nona Stallings, Michael C. Stefansson, Hreinn Stefansson, Kari Stitzel, Jerry A. Sun, Xiao Syed, Moin Tal-Singer, Ruth Taylor, Amy E. Taylor, Kent D. Telen, Marilyn J. Thai, Khanh K. Tiwari, Hemant Turman, Constance Tyrfingsson, Thorarinn Wall, Tamara L. Walters, Robin G. Weir, David R. Weiss, Scott T. White, Wendy B. Whitfield, John B. Wiggins, Kerri L. Willemsen, Gonneke Willer, Cristen J. Winsvold, Bendik S. Xu, Huichun Yanek, Lisa R. Yin, Jie Young, Kristin L. Young, Kendra A. Yu, Bing Zhao, Wei Zhou, Wei Zöllner, Sebastian Zuccolo, Luisa Batini, Chiara Bergen, Andrew W. Bierut, Laura J. David, Sean P. Gagliano Taliun, Sarah A. Hancock, Dana B. Jiang, Bibo Munafò, Marcus R. Thorgeirsson, Thorgeir E. Liu, Dajiang J. Vrieze, Scott Nature Article Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury(1–4). These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries(5). Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in sample size and genetic diversity improved locus identification and fine-mapping resolution, and that a large majority of the 3,823 associated variants (from 2,143 loci) showed consistent effect sizes across ancestry dimensions. However, polygenic risk scores developed in one ancestry performed poorly in others, highlighting the continued need to increase sample sizes of diverse ancestries to realize any potential benefit of polygenic prediction. Nature Publishing Group UK 2022-12-07 2022 /pmc/articles/PMC9771818/ /pubmed/36477530 http://dx.doi.org/10.1038/s41586-022-05477-4 Text en © The Author(s) 2022, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Saunders, Gretchen R. B. Wang, Xingyan Chen, Fang Jang, Seon-Kyeong Liu, Mengzhen Wang, Chen Gao, Shuang Jiang, Yu Khunsriraksakul, Chachrit Otto, Jacqueline M. Addison, Clifton Akiyama, Masato Albert, Christine M. Aliev, Fazil Alonso, Alvaro Arnett, Donna K. Ashley-Koch, Allison E. Ashrani, Aneel A. Barnes, Kathleen C. Barr, R. Graham Bartz, Traci M. Becker, Diane M. Bielak, Lawrence F. Benjamin, Emelia J. Bis, Joshua C. Bjornsdottir, Gyda Blangero, John Bleecker, Eugene R. Boardman, Jason D. Boerwinkle, Eric Boomsma, Dorret I. Boorgula, Meher Preethi Bowden, Donald W. Brody, Jennifer A. Cade, Brian E. Chasman, Daniel I. Chavan, Sameer Chen, Yii-Der Ida Chen, Zhengming Cheng, Iona Cho, Michael H. Choquet, Hélène Cole, John W. Cornelis, Marilyn C. Cucca, Francesco Curran, Joanne E. de Andrade, Mariza Dick, Danielle M. Docherty, Anna R. Duggirala, Ravindranath Eaton, Charles B. Ehringer, Marissa A. Esko, Tõnu Faul, Jessica D. Fernandes Silva, Lilian Fiorillo, Edoardo Fornage, Myriam Freedman, Barry I. Gabrielsen, Maiken E. Garrett, Melanie E. Gharib, Sina A. Gieger, Christian Gillespie, Nathan Glahn, David C. Gordon, Scott D. Gu, Charles C. Gu, Dongfeng Gudbjartsson, Daniel F. Guo, Xiuqing Haessler, Jeffrey Hall, Michael E. Haller, Toomas Harris, Kathleen Mullan He, Jiang Herd, Pamela Hewitt, John K. Hickie, Ian Hidalgo, Bertha Hokanson, John E. Hopfer, Christian Hottenga, JoukeJan Hou, Lifang Huang, Hongyan Hung, Yi-Jen Hunter, David J. Hveem, Kristian Hwang, Shih-Jen Hwu, Chii-Min Iacono, William Irvin, Marguerite R. Jee, Yon Ho Johnson, Eric O. Joo, Yoonjung Y. Jorgenson, Eric Justice, Anne E. Kamatani, Yoichiro Kaplan, Robert C. Kaprio, Jaakko Kardia, Sharon L. R. Keller, Matthew C. Kelly, Tanika N. Kooperberg, Charles Korhonen, Tellervo Kraft, Peter Krauter, Kenneth Kuusisto, Johanna Laakso, Markku Lasky-Su, Jessica Lee, Wen-Jane Lee, James J. Levy, Daniel Li, Liming Li, Kevin Li, Yuqing Lin, Kuang Lind, Penelope A. Liu, Chunyu Lloyd-Jones, Donald M. Lutz, Sharon M. Ma, Jiantao Mägi, Reedik Manichaikul, Ani Martin, Nicholas G. Mathur, Ravi Matoba, Nana McArdle, Patrick F. McGue, Matt McQueen, Matthew B. Medland, Sarah E. Metspalu, Andres Meyers, Deborah A. Millwood, Iona Y. Mitchell, Braxton D. Mohlke, Karen L. Moll, Matthew Montasser, May E. Morrison, Alanna C. Mulas, Antonella Nielsen, Jonas B. North, Kari E. Oelsner, Elizabeth C. Okada, Yukinori Orrù, Valeria Palmer, Nicholette D. Palviainen, Teemu Pandit, Anita Park, S. Lani Peters, Ulrike Peters, Annette Peyser, Patricia A. Polderman, Tinca J. C. Rafaels, Nicholas Redline, Susan Reed, Robert M. Reiner, Alex P. Rice, John P. Rich, Stephen S. Richmond, Nicole E. Roan, Carol Rotter, Jerome I. Rueschman, Michael N. Runarsdottir, Valgerdur Saccone, Nancy L. Schwartz, David A. Shadyab, Aladdin H. Shi, Jingchunzi Shringarpure, Suyash S. Sicinski, Kamil Skogholt, Anne Heidi Smith, Jennifer A. Smith, Nicholas L. Sotoodehnia, Nona Stallings, Michael C. Stefansson, Hreinn Stefansson, Kari Stitzel, Jerry A. Sun, Xiao Syed, Moin Tal-Singer, Ruth Taylor, Amy E. Taylor, Kent D. Telen, Marilyn J. Thai, Khanh K. Tiwari, Hemant Turman, Constance Tyrfingsson, Thorarinn Wall, Tamara L. Walters, Robin G. Weir, David R. Weiss, Scott T. White, Wendy B. Whitfield, John B. Wiggins, Kerri L. Willemsen, Gonneke Willer, Cristen J. Winsvold, Bendik S. Xu, Huichun Yanek, Lisa R. Yin, Jie Young, Kristin L. Young, Kendra A. Yu, Bing Zhao, Wei Zhou, Wei Zöllner, Sebastian Zuccolo, Luisa Batini, Chiara Bergen, Andrew W. Bierut, Laura J. David, Sean P. Gagliano Taliun, Sarah A. Hancock, Dana B. Jiang, Bibo Munafò, Marcus R. Thorgeirsson, Thorgeir E. Liu, Dajiang J. Vrieze, Scott Genetic diversity fuels gene discovery for tobacco and alcohol use |
title | Genetic diversity fuels gene discovery for tobacco and alcohol use |
title_full | Genetic diversity fuels gene discovery for tobacco and alcohol use |
title_fullStr | Genetic diversity fuels gene discovery for tobacco and alcohol use |
title_full_unstemmed | Genetic diversity fuels gene discovery for tobacco and alcohol use |
title_short | Genetic diversity fuels gene discovery for tobacco and alcohol use |
title_sort | genetic diversity fuels gene discovery for tobacco and alcohol use |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771818/ https://www.ncbi.nlm.nih.gov/pubmed/36477530 http://dx.doi.org/10.1038/s41586-022-05477-4 |
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