Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice

RNA alternative splicing (AS) expands the regulatory potential of eukaryotic genomes. The mechanisms regulating liver-specific AS profiles and their contribution to liver function are poorly understood. Here, we identify a key role for the splicing factor RNA-binding Fox protein 2 (RBFOX2) in mainta...

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Detalles Bibliográficos
Autores principales: Paterson, Helen A. B., Yu, Sijia, Artigas, Natalia, Prado, Miguel A., Haberman, Nejc, Wang, Yi-Fang, Jobbins, Andrew M., Pahita, Elena, Mokochinski, Joao, Hall, Zoe, Guerin, Maryse, Paulo, Joao A., Ng, Soon Seng, Villarroya, Francesc, Rashid, Sheikh Tamir, Le Goff, Wilfried, Lenhard, Boris, Cebola, Inês, Finley, Daniel, Gygi, Steven P., Sibley, Christopher R., Vernia, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771820/
https://www.ncbi.nlm.nih.gov/pubmed/36536133
http://dx.doi.org/10.1038/s42255-022-00681-y

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