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Longitudinal assessment of maternal depression and early childhood asthma and wheeze: Effect modification by child sex
BACKGROUND: Studies report associations between maternal mental health and adverse respiratory outcomes in children; however, the impact of timing and duration of maternal distress remains understudied. We sought to longitudinally examine associations between maternal depression and childhood asthma...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771993/ https://www.ncbi.nlm.nih.gov/pubmed/36128727 http://dx.doi.org/10.1002/ppul.26164 |
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author | Alcala, Cecilia S. Orozco Scott, Paloma Tamayo‐Ortiz, Marcela Hernández Chávez, Maria del Carmen Schnaas, Lourdes Carroll, Kecia N. Niedzwiecki, Megan M. Wright, Robert O. Téllez‐Rojo, Martha Maria Wright, Rosalind J. Hsu, Hsiao‐Hsien Leon Rosa, Maria José |
author_facet | Alcala, Cecilia S. Orozco Scott, Paloma Tamayo‐Ortiz, Marcela Hernández Chávez, Maria del Carmen Schnaas, Lourdes Carroll, Kecia N. Niedzwiecki, Megan M. Wright, Robert O. Téllez‐Rojo, Martha Maria Wright, Rosalind J. Hsu, Hsiao‐Hsien Leon Rosa, Maria José |
author_sort | Alcala, Cecilia S. |
collection | PubMed |
description | BACKGROUND: Studies report associations between maternal mental health and adverse respiratory outcomes in children; however, the impact of timing and duration of maternal distress remains understudied. We sought to longitudinally examine associations between maternal depression and childhood asthma and wheeze, and explore sex differences. METHODS: Maternal depression (n = 601) was assessed using the Edinburgh Depression Scale questionnaire, dichotomized at a clinically relevant cutoff (>12) (a) during pregnancy, (b) postpartum, and (c) postpartum and subsequent time points postnatally (recurrent depression). Report of wheeze in the past 12 months (current wheeze) and asthma were obtained using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire at 48 and 72 months. Associations were analyzed using a modified Poisson regression adjusted for covariates, and in interaction models. RESULTS: Both postpartum and recurrent depression were associated with higher risk of current wheeze (relative risk [RR]: 1.87, 95% confidence interval [CI]: 1.21, 2.90; RR: 2.41, 95% CI: 1.53, 3.79) and asthma at 48 months (RR: 2.42, 95% CI: 1.01, 5.84; RR: 2.45, 95% CI: 1.02, 5.84). In interaction analyses, associations were stronger in females. Recurrent depression was associated with a higher risk of current wheeze at 48 months in females (RR: 4.34, 95% CI: 2.02, 9.32) when compared to males (RR: 1.89, 95% CI: 1.05, 3.39). CONCLUSIONS: Postpartum and recurrent depression were associated with a higher risk of wheeze and asthma in children. Understanding the temporal‐ and sex‐specific effects of maternal depression may better inform prevention strategies. |
format | Online Article Text |
id | pubmed-9771993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97719932023-04-13 Longitudinal assessment of maternal depression and early childhood asthma and wheeze: Effect modification by child sex Alcala, Cecilia S. Orozco Scott, Paloma Tamayo‐Ortiz, Marcela Hernández Chávez, Maria del Carmen Schnaas, Lourdes Carroll, Kecia N. Niedzwiecki, Megan M. Wright, Robert O. Téllez‐Rojo, Martha Maria Wright, Rosalind J. Hsu, Hsiao‐Hsien Leon Rosa, Maria José Pediatr Pulmonol Original Articles BACKGROUND: Studies report associations between maternal mental health and adverse respiratory outcomes in children; however, the impact of timing and duration of maternal distress remains understudied. We sought to longitudinally examine associations between maternal depression and childhood asthma and wheeze, and explore sex differences. METHODS: Maternal depression (n = 601) was assessed using the Edinburgh Depression Scale questionnaire, dichotomized at a clinically relevant cutoff (>12) (a) during pregnancy, (b) postpartum, and (c) postpartum and subsequent time points postnatally (recurrent depression). Report of wheeze in the past 12 months (current wheeze) and asthma were obtained using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire at 48 and 72 months. Associations were analyzed using a modified Poisson regression adjusted for covariates, and in interaction models. RESULTS: Both postpartum and recurrent depression were associated with higher risk of current wheeze (relative risk [RR]: 1.87, 95% confidence interval [CI]: 1.21, 2.90; RR: 2.41, 95% CI: 1.53, 3.79) and asthma at 48 months (RR: 2.42, 95% CI: 1.01, 5.84; RR: 2.45, 95% CI: 1.02, 5.84). In interaction analyses, associations were stronger in females. Recurrent depression was associated with a higher risk of current wheeze at 48 months in females (RR: 4.34, 95% CI: 2.02, 9.32) when compared to males (RR: 1.89, 95% CI: 1.05, 3.39). CONCLUSIONS: Postpartum and recurrent depression were associated with a higher risk of wheeze and asthma in children. Understanding the temporal‐ and sex‐specific effects of maternal depression may better inform prevention strategies. John Wiley and Sons Inc. 2022-10-04 2023-01 /pmc/articles/PMC9771993/ /pubmed/36128727 http://dx.doi.org/10.1002/ppul.26164 Text en © 2022 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Alcala, Cecilia S. Orozco Scott, Paloma Tamayo‐Ortiz, Marcela Hernández Chávez, Maria del Carmen Schnaas, Lourdes Carroll, Kecia N. Niedzwiecki, Megan M. Wright, Robert O. Téllez‐Rojo, Martha Maria Wright, Rosalind J. Hsu, Hsiao‐Hsien Leon Rosa, Maria José Longitudinal assessment of maternal depression and early childhood asthma and wheeze: Effect modification by child sex |
title | Longitudinal assessment of maternal depression and early childhood asthma and wheeze: Effect modification by child sex |
title_full | Longitudinal assessment of maternal depression and early childhood asthma and wheeze: Effect modification by child sex |
title_fullStr | Longitudinal assessment of maternal depression and early childhood asthma and wheeze: Effect modification by child sex |
title_full_unstemmed | Longitudinal assessment of maternal depression and early childhood asthma and wheeze: Effect modification by child sex |
title_short | Longitudinal assessment of maternal depression and early childhood asthma and wheeze: Effect modification by child sex |
title_sort | longitudinal assessment of maternal depression and early childhood asthma and wheeze: effect modification by child sex |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771993/ https://www.ncbi.nlm.nih.gov/pubmed/36128727 http://dx.doi.org/10.1002/ppul.26164 |
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