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The natural growth history of persistent pulmonary subsolid nodules: Radiology, genetics, and clinical management

The high detection rate of pulmonary subsolid nodules (SSN) is an increasingly crucial clinical issue due to the increased number of screening tests and the growing popularity of low-dose computed tomography (LDCT). The persistence of SSN strongly suggests the possibility of malignancy. Guidelines h...

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Detalles Bibliográficos
Autores principales: Zhang, Zhedong, Zhou, Lixin, Yang, Fan, Li, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772280/
https://www.ncbi.nlm.nih.gov/pubmed/36568242
http://dx.doi.org/10.3389/fonc.2022.1011712
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author Zhang, Zhedong
Zhou, Lixin
Yang, Fan
Li, Xiao
author_facet Zhang, Zhedong
Zhou, Lixin
Yang, Fan
Li, Xiao
author_sort Zhang, Zhedong
collection PubMed
description The high detection rate of pulmonary subsolid nodules (SSN) is an increasingly crucial clinical issue due to the increased number of screening tests and the growing popularity of low-dose computed tomography (LDCT). The persistence of SSN strongly suggests the possibility of malignancy. Guidelines have been published over the past few years and guide the optimal management of SSNs, but many remain controversial and confusing for clinicians. Therefore, in-depth research on the natural growth history of persistent pulmonary SSN can help provide evidence-based medical recommendations for nodule management. In this review, we briefly describe the differential diagnosis, growth patterns and rates, genetic characteristics, and factors that influence the growth of persistent SSN. With the advancement of radiomics and artificial intelligence (AI) technology, individualized evaluation of SSN becomes possible. These technologies together with liquid biopsy, will promote the transformation of current diagnosis and follow-up strategies and provide significant progress in the precise management of subsolid nodules in the early stage of lung cancer.
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spelling pubmed-97722802022-12-23 The natural growth history of persistent pulmonary subsolid nodules: Radiology, genetics, and clinical management Zhang, Zhedong Zhou, Lixin Yang, Fan Li, Xiao Front Oncol Oncology The high detection rate of pulmonary subsolid nodules (SSN) is an increasingly crucial clinical issue due to the increased number of screening tests and the growing popularity of low-dose computed tomography (LDCT). The persistence of SSN strongly suggests the possibility of malignancy. Guidelines have been published over the past few years and guide the optimal management of SSNs, but many remain controversial and confusing for clinicians. Therefore, in-depth research on the natural growth history of persistent pulmonary SSN can help provide evidence-based medical recommendations for nodule management. In this review, we briefly describe the differential diagnosis, growth patterns and rates, genetic characteristics, and factors that influence the growth of persistent SSN. With the advancement of radiomics and artificial intelligence (AI) technology, individualized evaluation of SSN becomes possible. These technologies together with liquid biopsy, will promote the transformation of current diagnosis and follow-up strategies and provide significant progress in the precise management of subsolid nodules in the early stage of lung cancer. Frontiers Media S.A. 2022-12-08 /pmc/articles/PMC9772280/ /pubmed/36568242 http://dx.doi.org/10.3389/fonc.2022.1011712 Text en Copyright © 2022 Zhang, Zhou, Yang and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhang, Zhedong
Zhou, Lixin
Yang, Fan
Li, Xiao
The natural growth history of persistent pulmonary subsolid nodules: Radiology, genetics, and clinical management
title The natural growth history of persistent pulmonary subsolid nodules: Radiology, genetics, and clinical management
title_full The natural growth history of persistent pulmonary subsolid nodules: Radiology, genetics, and clinical management
title_fullStr The natural growth history of persistent pulmonary subsolid nodules: Radiology, genetics, and clinical management
title_full_unstemmed The natural growth history of persistent pulmonary subsolid nodules: Radiology, genetics, and clinical management
title_short The natural growth history of persistent pulmonary subsolid nodules: Radiology, genetics, and clinical management
title_sort natural growth history of persistent pulmonary subsolid nodules: radiology, genetics, and clinical management
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772280/
https://www.ncbi.nlm.nih.gov/pubmed/36568242
http://dx.doi.org/10.3389/fonc.2022.1011712
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