Targeting SPHK1/S1PR3-regulated S-1-P metabolic disorder triggers autophagic cell death in pulmonary lymphangiomyomatosis (LAM)

Lymphangioleiomyomatosis (LAM), a progressive pulmonary disease exclusively affecting females, is caused by defects or mutations in the coding gene tuberous sclerosis complex 1 (TSC1) or TSC2, causing the mammalian target of rapamycin complex 1 (mTORC1) activation and autophagy inhibition. Clinicall...

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Detalles Bibliográficos
Autores principales: Li, Fei, Zhang, Yifan, Lin, Zhoujun, Yan, Lizhong, Liu, Qiao, Li, Yin, Pei, Xiaolin, Feng, Ya, Han, Xiao, Yang, Juan, Zheng, Fangxu, Li, Tianjiao, Zhang, Yupeng, Fu, Zhenkun, Shao, Di, Yu, Jane, Li, Chenggang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772321/
https://www.ncbi.nlm.nih.gov/pubmed/36543771
http://dx.doi.org/10.1038/s41419-022-05511-3

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