Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site

Contemporary influenza A H3N2 viruses circulating since 2016 have acquired a glycosylation site in the neuraminidase in close proximity to the enzymatic active site. Here, we investigate if this S245N glycosylation site, as a result of antigenic evolution, can impact binding and function of human mo...

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Detalles Bibliográficos
Autores principales: Stadlbauer, Daniel, McMahon, Meagan, Turner, Hannah L., Zhu, Xueyong, Wan, Hongquan, Carreño, Juan Manuel, O’Dell, George, Strohmeier, Shirin, Khalil, Zain, Luksza, Marta, van Bakel, Harm, Simon, Viviana, Ellebedy, Ali H., Wilson, Ian A., Ward, Andrew B., Krammer, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772378/
https://www.ncbi.nlm.nih.gov/pubmed/36543789
http://dx.doi.org/10.1038/s41467-022-35586-7

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