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Anti-immunoglobulin-like transcript 3 induced acute myocarditis—A case report

To the best of our knowledge, this is the first published report of anti-immunoglobulin-like transcript 3 (ILT3)-induced myocarditis. A 48-year old female patient with refractory acute myeloid leukemia who was given a single dose of anti-ILT3 monotherapy presented with fever, hypotension, chest pain...

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Autores principales: Itzhaki Ben Zadok, Osnat, Shiyovich, Arthur, Hamdan, Ashraf, Yeshurun, Moshe, Nardi Agmon, Inbar, Raanani, Pia, Kornowski, Ran, Shargian, Liat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772458/
https://www.ncbi.nlm.nih.gov/pubmed/36568550
http://dx.doi.org/10.3389/fcvm.2022.1035569
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author Itzhaki Ben Zadok, Osnat
Shiyovich, Arthur
Hamdan, Ashraf
Yeshurun, Moshe
Nardi Agmon, Inbar
Raanani, Pia
Kornowski, Ran
Shargian, Liat
author_facet Itzhaki Ben Zadok, Osnat
Shiyovich, Arthur
Hamdan, Ashraf
Yeshurun, Moshe
Nardi Agmon, Inbar
Raanani, Pia
Kornowski, Ran
Shargian, Liat
author_sort Itzhaki Ben Zadok, Osnat
collection PubMed
description To the best of our knowledge, this is the first published report of anti-immunoglobulin-like transcript 3 (ILT3)-induced myocarditis. A 48-year old female patient with refractory acute myeloid leukemia who was given a single dose of anti-ILT3 monotherapy presented with fever, hypotension, chest pain, and elevated cardiac biomarkers. Systolic bi-ventricular function was in normal limits. The patient was promptly treated with pulse dose steroids with a rapid hemodynamic and clinical improvement and declining levels of cardiac biomarkers. The diagnosis of acute myocarditis was confirmed using cardiac magnetic resonance imaging applying the revised Lake Lewis criteria. While larger-scale data are needed in order to assess the incidence, management and prognosis of anti-ILT-3 induced myocarditis, we believe a high level of suspicion for adverse non-target cardiac effects is required in patients receiving this novel class of drugs.
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spelling pubmed-97724582022-12-23 Anti-immunoglobulin-like transcript 3 induced acute myocarditis—A case report Itzhaki Ben Zadok, Osnat Shiyovich, Arthur Hamdan, Ashraf Yeshurun, Moshe Nardi Agmon, Inbar Raanani, Pia Kornowski, Ran Shargian, Liat Front Cardiovasc Med Cardiovascular Medicine To the best of our knowledge, this is the first published report of anti-immunoglobulin-like transcript 3 (ILT3)-induced myocarditis. A 48-year old female patient with refractory acute myeloid leukemia who was given a single dose of anti-ILT3 monotherapy presented with fever, hypotension, chest pain, and elevated cardiac biomarkers. Systolic bi-ventricular function was in normal limits. The patient was promptly treated with pulse dose steroids with a rapid hemodynamic and clinical improvement and declining levels of cardiac biomarkers. The diagnosis of acute myocarditis was confirmed using cardiac magnetic resonance imaging applying the revised Lake Lewis criteria. While larger-scale data are needed in order to assess the incidence, management and prognosis of anti-ILT-3 induced myocarditis, we believe a high level of suspicion for adverse non-target cardiac effects is required in patients receiving this novel class of drugs. Frontiers Media S.A. 2022-12-08 /pmc/articles/PMC9772458/ /pubmed/36568550 http://dx.doi.org/10.3389/fcvm.2022.1035569 Text en Copyright © 2022 Itzhaki Ben Zadok, Shiyovich, Hamdan, Yeshurun, Nardi Agmon, Raanani, Kornowski and Shargian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Itzhaki Ben Zadok, Osnat
Shiyovich, Arthur
Hamdan, Ashraf
Yeshurun, Moshe
Nardi Agmon, Inbar
Raanani, Pia
Kornowski, Ran
Shargian, Liat
Anti-immunoglobulin-like transcript 3 induced acute myocarditis—A case report
title Anti-immunoglobulin-like transcript 3 induced acute myocarditis—A case report
title_full Anti-immunoglobulin-like transcript 3 induced acute myocarditis—A case report
title_fullStr Anti-immunoglobulin-like transcript 3 induced acute myocarditis—A case report
title_full_unstemmed Anti-immunoglobulin-like transcript 3 induced acute myocarditis—A case report
title_short Anti-immunoglobulin-like transcript 3 induced acute myocarditis—A case report
title_sort anti-immunoglobulin-like transcript 3 induced acute myocarditis—a case report
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772458/
https://www.ncbi.nlm.nih.gov/pubmed/36568550
http://dx.doi.org/10.3389/fcvm.2022.1035569
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