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COMORBIDITIES ASSOCIATED WITH RISK OF MYOCARDITIS IN HOSPITALIZED COVID-19 OLDER ADULTS
BACKGROUND: Older adults are afflicted more severely by COVID-19. SARS-CoV-2 can be complicated by myocarditis (MC), and the incidence of MC has been shown to correlate linearly with severity. However, data on comorbidities associated with MC in this population is scarce. METHODS: Data were obtained...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772506/ http://dx.doi.org/10.1093/geroni/igac059.3048 |
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author | Crawford, Andrew Redondo, Andres Zadeh, Ali Vaeli Wong, Alan Carrero, Ricardo Criado Fleischhacker, Alexander Collado, Elias Larned, Joshua |
author_facet | Crawford, Andrew Redondo, Andres Zadeh, Ali Vaeli Wong, Alan Carrero, Ricardo Criado Fleischhacker, Alexander Collado, Elias Larned, Joshua |
author_sort | Crawford, Andrew |
collection | PubMed |
description | BACKGROUND: Older adults are afflicted more severely by COVID-19. SARS-CoV-2 can be complicated by myocarditis (MC), and the incidence of MC has been shown to correlate linearly with severity. However, data on comorbidities associated with MC in this population is scarce. METHODS: Data were obtained from the PearlDiver database (PearlDiver Technologies, Fort Wayne, IN). The study used ICD codes to include patients hospitalized with a primary diagnosis of COVID-19, aged 65–75, and Elixhauser Comorbidity index(ECI)>4. Within this cohort, we identified patients diagnosed with MC 60 days after admission and compared their baseline comorbidities upon admission to those without MC. Pearson’s chi-squared test was used to compare groups. The strength of association was reported by Risk Ratios (RR). A p-value < 0.05 was deemed significant. RESULTS: 412,582 patients admitted with COVID-19 as the primary diagnosis were identified. 0.12% of this cohort developed MC over the following 60 days. The MC group was more likely to be male(57%, p=0.0001), with similar mean age(70.4, p=0.86) and mean ECI(9.4, p=0.07) to the no-MC group. Patients who developed MC have significantly higher rates of prior heart failure(RR= 1.30, CI95%=1.07–1.57, p=0.008). There was no difference between groups in terms of history of arrhythmias(p=0.36), cerebrovascular disease(p=0.09), chronic kidney disease(p=0.13), CAD(P=0.19), diabetes(p=0.48), ischemic heart disease(p=0.06), tobacco use(p=0.39), alcohol use(p=0.17), HIV(p=0.79), and severe liver disease(p=0.14). CONCLUSION: A history of heart failure increased the likelihood of developing MC in older adults. |
format | Online Article Text |
id | pubmed-9772506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-97725062022-12-22 COMORBIDITIES ASSOCIATED WITH RISK OF MYOCARDITIS IN HOSPITALIZED COVID-19 OLDER ADULTS Crawford, Andrew Redondo, Andres Zadeh, Ali Vaeli Wong, Alan Carrero, Ricardo Criado Fleischhacker, Alexander Collado, Elias Larned, Joshua Innov Aging Late Breaking Abstracts BACKGROUND: Older adults are afflicted more severely by COVID-19. SARS-CoV-2 can be complicated by myocarditis (MC), and the incidence of MC has been shown to correlate linearly with severity. However, data on comorbidities associated with MC in this population is scarce. METHODS: Data were obtained from the PearlDiver database (PearlDiver Technologies, Fort Wayne, IN). The study used ICD codes to include patients hospitalized with a primary diagnosis of COVID-19, aged 65–75, and Elixhauser Comorbidity index(ECI)>4. Within this cohort, we identified patients diagnosed with MC 60 days after admission and compared their baseline comorbidities upon admission to those without MC. Pearson’s chi-squared test was used to compare groups. The strength of association was reported by Risk Ratios (RR). A p-value < 0.05 was deemed significant. RESULTS: 412,582 patients admitted with COVID-19 as the primary diagnosis were identified. 0.12% of this cohort developed MC over the following 60 days. The MC group was more likely to be male(57%, p=0.0001), with similar mean age(70.4, p=0.86) and mean ECI(9.4, p=0.07) to the no-MC group. Patients who developed MC have significantly higher rates of prior heart failure(RR= 1.30, CI95%=1.07–1.57, p=0.008). There was no difference between groups in terms of history of arrhythmias(p=0.36), cerebrovascular disease(p=0.09), chronic kidney disease(p=0.13), CAD(P=0.19), diabetes(p=0.48), ischemic heart disease(p=0.06), tobacco use(p=0.39), alcohol use(p=0.17), HIV(p=0.79), and severe liver disease(p=0.14). CONCLUSION: A history of heart failure increased the likelihood of developing MC in older adults. Oxford University Press 2022-12-20 /pmc/articles/PMC9772506/ http://dx.doi.org/10.1093/geroni/igac059.3048 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Late Breaking Abstracts Crawford, Andrew Redondo, Andres Zadeh, Ali Vaeli Wong, Alan Carrero, Ricardo Criado Fleischhacker, Alexander Collado, Elias Larned, Joshua COMORBIDITIES ASSOCIATED WITH RISK OF MYOCARDITIS IN HOSPITALIZED COVID-19 OLDER ADULTS |
title | COMORBIDITIES ASSOCIATED WITH RISK OF MYOCARDITIS IN HOSPITALIZED COVID-19 OLDER ADULTS |
title_full | COMORBIDITIES ASSOCIATED WITH RISK OF MYOCARDITIS IN HOSPITALIZED COVID-19 OLDER ADULTS |
title_fullStr | COMORBIDITIES ASSOCIATED WITH RISK OF MYOCARDITIS IN HOSPITALIZED COVID-19 OLDER ADULTS |
title_full_unstemmed | COMORBIDITIES ASSOCIATED WITH RISK OF MYOCARDITIS IN HOSPITALIZED COVID-19 OLDER ADULTS |
title_short | COMORBIDITIES ASSOCIATED WITH RISK OF MYOCARDITIS IN HOSPITALIZED COVID-19 OLDER ADULTS |
title_sort | comorbidities associated with risk of myocarditis in hospitalized covid-19 older adults |
topic | Late Breaking Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772506/ http://dx.doi.org/10.1093/geroni/igac059.3048 |
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