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Impact of CD4 T cells on intratumoral CD8 T-cell exhaustion and responsiveness to PD-1 blockade therapy in mouse brain tumors

BACKGROUND: Glioblastoma is a fatal disease despite aggressive multimodal therapy. PD-1 blockade, a therapy that reinvigorates hypofunctional exhausted CD8 T cells (T(ex)) in many malignancies, has not shown efficacy in glioblastoma. Loss of CD4 T cells can lead to an exhausted CD8 T-cell phenotype,...

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Detalles Bibliográficos
Autores principales:	Khan, Saad M, Desai, Rupen, Coxon, Andrew, Livingstone, Alexandra, Dunn, Gavin P, Petti, Allegra, Johanns, Tanner M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772691/ https://www.ncbi.nlm.nih.gov/pubmed/36543376 http://dx.doi.org/10.1136/jitc-2022-005293

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