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Exploring genetic and immune underpinnings of the sexual dimorphism in tumor response to immune checkpoints inhibitors: A narrative review
INTRODUCTION: In spite of the undisputed relevance of sex as critical biologic variable of the immune landscape, still limited is our understanding of the basic mechanisms implicated in sex-biased immune response thereby conditioning the therapeutic outcome in cancer patients. This hindrance delays...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772791/ https://www.ncbi.nlm.nih.gov/pubmed/36571078 http://dx.doi.org/10.1016/j.crphar.2022.100146 |
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author | Mazzaschi, Giulia Quaini, Federico Buti, Sebastiano |
author_facet | Mazzaschi, Giulia Quaini, Federico Buti, Sebastiano |
author_sort | Mazzaschi, Giulia |
collection | PubMed |
description | INTRODUCTION: In spite of the undisputed relevance of sex as critical biologic variable of the immune landscape, still limited is our understanding of the basic mechanisms implicated in sex-biased immune response thereby conditioning the therapeutic outcome in cancer patients. This hindrance delays the actual attempts to decipher the heterogeneity of cancer and its immune surveillance, further digressing the achievement of predictive biomarkers in the current immunotherapy-driven scenario. Body: The present review concisely reports on genetic, chromosomal, hormonal, and immune features underlying sex-differences in the response to immune checkpoint inhibitors (ICIs). In addition to outline the need of robust data on ICI pharmaco-kinetics/dynamics, our survey might provide new insights on sex determinants of ICI efficacy and suggests uncovered pathways that warrant prospective investigations. CONCLUSION: According to a sharable view, we propose to widely include sex among the co-variates when assessing the clinical response to ICI in cancer patients. |
format | Online Article Text |
id | pubmed-9772791 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-97727912022-12-23 Exploring genetic and immune underpinnings of the sexual dimorphism in tumor response to immune checkpoints inhibitors: A narrative review Mazzaschi, Giulia Quaini, Federico Buti, Sebastiano Curr Res Pharmacol Drug Discov Research Article INTRODUCTION: In spite of the undisputed relevance of sex as critical biologic variable of the immune landscape, still limited is our understanding of the basic mechanisms implicated in sex-biased immune response thereby conditioning the therapeutic outcome in cancer patients. This hindrance delays the actual attempts to decipher the heterogeneity of cancer and its immune surveillance, further digressing the achievement of predictive biomarkers in the current immunotherapy-driven scenario. Body: The present review concisely reports on genetic, chromosomal, hormonal, and immune features underlying sex-differences in the response to immune checkpoint inhibitors (ICIs). In addition to outline the need of robust data on ICI pharmaco-kinetics/dynamics, our survey might provide new insights on sex determinants of ICI efficacy and suggests uncovered pathways that warrant prospective investigations. CONCLUSION: According to a sharable view, we propose to widely include sex among the co-variates when assessing the clinical response to ICI in cancer patients. Elsevier 2022-12-07 /pmc/articles/PMC9772791/ /pubmed/36571078 http://dx.doi.org/10.1016/j.crphar.2022.100146 Text en © 2022 Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Mazzaschi, Giulia Quaini, Federico Buti, Sebastiano Exploring genetic and immune underpinnings of the sexual dimorphism in tumor response to immune checkpoints inhibitors: A narrative review |
title | Exploring genetic and immune underpinnings of the sexual dimorphism in tumor response to immune checkpoints inhibitors: A narrative review |
title_full | Exploring genetic and immune underpinnings of the sexual dimorphism in tumor response to immune checkpoints inhibitors: A narrative review |
title_fullStr | Exploring genetic and immune underpinnings of the sexual dimorphism in tumor response to immune checkpoints inhibitors: A narrative review |
title_full_unstemmed | Exploring genetic and immune underpinnings of the sexual dimorphism in tumor response to immune checkpoints inhibitors: A narrative review |
title_short | Exploring genetic and immune underpinnings of the sexual dimorphism in tumor response to immune checkpoints inhibitors: A narrative review |
title_sort | exploring genetic and immune underpinnings of the sexual dimorphism in tumor response to immune checkpoints inhibitors: a narrative review |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772791/ https://www.ncbi.nlm.nih.gov/pubmed/36571078 http://dx.doi.org/10.1016/j.crphar.2022.100146 |
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