Improved protein glycosylation enabled heterologous biosynthesis of monoterpenoid indole alkaloids and their unnatural derivatives in yeast

With over 3000 reported structures, monoterpenoid indole alkaloids (MIAs) constitute one of the largest alkaloid groups in nature, including the clinically important anticancer drug vinblastine and its semi-synthetic derivatives from Catharanthus roseus (Madagascar’s periwinkle). With the elucidatio...

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Detalles Bibliográficos
Autores principales: Shahsavarani, Mohammadamin, Utomo, Joseph Christian, Kumar, Rahul, Paz-Galeano, Melina, Garza-García, Jorge Jonathan Oswaldo, Mai, Zhan, Ro, Dae-Kyun, Qu, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Short communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772838/
https://www.ncbi.nlm.nih.gov/pubmed/36569379
http://dx.doi.org/10.1016/j.mec.2022.e00215

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