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A new polymorphism of human amylin fibrils with similar protofilaments and a conserved core

Pancreatic amyloid deposits composed of a fibrillar form of the human islet amyloid polypeptide (hIAPP) are the pathological hallmark of type 2 diabetes (T2D). Although various cryo-EM structures of polymorphic hIAPP fibrils were reported, the underlying polymorphic mechanism of hIAPP remains elusiv...

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Detalles Bibliográficos
Autores principales:	Li, Dongyu, Zhang, Xueli, Wang, Youwang, Zhang, Haonan, Song, Kai, Bao, Keyan, Zhu, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772857/ https://www.ncbi.nlm.nih.gov/pubmed/36567711 http://dx.doi.org/10.1016/j.isci.2022.105705

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