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The relation of depression with structural brain abnormalities and cognitive functioning: the Maastricht study

BACKGROUND: Individuals with depression often experience widespread and persistent cognitive deficits, which might be due to brain atrophy and cerebral small vessel disease (CSVD). We therefore studied the associations between depression, markers of brain atrophy and CSVD, and cognitive functioning....

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Autores principales: Geraets, Anouk F. J., Schram, Miranda T., Jansen, Jacobus F. A., Koster, Annemarie, Dagnelie, Pieter C., van Greevenbroek, Marleen M. J., Stehouwer, Coen D. A., Verhey, Frans R. J., Köhler, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772903/
https://www.ncbi.nlm.nih.gov/pubmed/33634767
http://dx.doi.org/10.1017/S0033291721000222
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author Geraets, Anouk F. J.
Schram, Miranda T.
Jansen, Jacobus F. A.
Koster, Annemarie
Dagnelie, Pieter C.
van Greevenbroek, Marleen M. J.
Stehouwer, Coen D. A.
Verhey, Frans R. J.
Köhler, Sebastian
author_facet Geraets, Anouk F. J.
Schram, Miranda T.
Jansen, Jacobus F. A.
Koster, Annemarie
Dagnelie, Pieter C.
van Greevenbroek, Marleen M. J.
Stehouwer, Coen D. A.
Verhey, Frans R. J.
Köhler, Sebastian
author_sort Geraets, Anouk F. J.
collection PubMed
description BACKGROUND: Individuals with depression often experience widespread and persistent cognitive deficits, which might be due to brain atrophy and cerebral small vessel disease (CSVD). We therefore studied the associations between depression, markers of brain atrophy and CSVD, and cognitive functioning. METHODS: We used cross-sectional data from the population-based Maastricht study (n = 4734; mean age 59.1 ± 8.6 years, 50.2% women), which focuses on type 2 diabetes. A current episode of major depressive disorder (MDD, n = 151) was assessed by the Mini-International Neuropsychiatric Interview. Volumes of cerebral spinal fluid, white matter, gray matter and white matter hyperintensities, presence of lacunar infarcts and cerebral microbleeds, and total CSVD burden were assessed by 3 T magnetic resonance imaging. Multiple linear and logistic regression analyses tested the associations between MDD, brain markers and cognitive functioning in memory, information processing speed, and executive functioning & attention, and presence of cognitive impairment. Structural equation modeling was used to test mediation. RESULTS: In fully adjusted models, MDD was associated with lower scores in information processing speed [mean difference = −0.18(−0.28;−0.08)], executive functioning & attention [mean difference = −0.13(−0.25;−0.02)], and with higher odds of cognitive impairment [odds ratio (OR) = 1.60(1.06;2.40)]. MDD was associated with CSVD in participants without type 2 diabetes [OR = 1.65(1.06;2.56)], but CSVD or other markers of brain atrophy or CSVD did not mediate the association with cognitive functioning. CONCLUSIONS: MDD is associated with more impaired information processing speed and executive functioning & attention, and overall cognitive impairment. Furthermore, MDD was associated with CSVD in participants without type 2 diabetes, but this association did not explain an impaired cognitive profile.
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spelling pubmed-97729032022-12-28 The relation of depression with structural brain abnormalities and cognitive functioning: the Maastricht study Geraets, Anouk F. J. Schram, Miranda T. Jansen, Jacobus F. A. Koster, Annemarie Dagnelie, Pieter C. van Greevenbroek, Marleen M. J. Stehouwer, Coen D. A. Verhey, Frans R. J. Köhler, Sebastian Psychol Med Original Article BACKGROUND: Individuals with depression often experience widespread and persistent cognitive deficits, which might be due to brain atrophy and cerebral small vessel disease (CSVD). We therefore studied the associations between depression, markers of brain atrophy and CSVD, and cognitive functioning. METHODS: We used cross-sectional data from the population-based Maastricht study (n = 4734; mean age 59.1 ± 8.6 years, 50.2% women), which focuses on type 2 diabetes. A current episode of major depressive disorder (MDD, n = 151) was assessed by the Mini-International Neuropsychiatric Interview. Volumes of cerebral spinal fluid, white matter, gray matter and white matter hyperintensities, presence of lacunar infarcts and cerebral microbleeds, and total CSVD burden were assessed by 3 T magnetic resonance imaging. Multiple linear and logistic regression analyses tested the associations between MDD, brain markers and cognitive functioning in memory, information processing speed, and executive functioning & attention, and presence of cognitive impairment. Structural equation modeling was used to test mediation. RESULTS: In fully adjusted models, MDD was associated with lower scores in information processing speed [mean difference = −0.18(−0.28;−0.08)], executive functioning & attention [mean difference = −0.13(−0.25;−0.02)], and with higher odds of cognitive impairment [odds ratio (OR) = 1.60(1.06;2.40)]. MDD was associated with CSVD in participants without type 2 diabetes [OR = 1.65(1.06;2.56)], but CSVD or other markers of brain atrophy or CSVD did not mediate the association with cognitive functioning. CONCLUSIONS: MDD is associated with more impaired information processing speed and executive functioning & attention, and overall cognitive impairment. Furthermore, MDD was associated with CSVD in participants without type 2 diabetes, but this association did not explain an impaired cognitive profile. Cambridge University Press 2022-11 2021-02-26 /pmc/articles/PMC9772903/ /pubmed/33634767 http://dx.doi.org/10.1017/S0033291721000222 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re- use, distribution and reproduction, provided the original article is properly cited.
spellingShingle Original Article
Geraets, Anouk F. J.
Schram, Miranda T.
Jansen, Jacobus F. A.
Koster, Annemarie
Dagnelie, Pieter C.
van Greevenbroek, Marleen M. J.
Stehouwer, Coen D. A.
Verhey, Frans R. J.
Köhler, Sebastian
The relation of depression with structural brain abnormalities and cognitive functioning: the Maastricht study
title The relation of depression with structural brain abnormalities and cognitive functioning: the Maastricht study
title_full The relation of depression with structural brain abnormalities and cognitive functioning: the Maastricht study
title_fullStr The relation of depression with structural brain abnormalities and cognitive functioning: the Maastricht study
title_full_unstemmed The relation of depression with structural brain abnormalities and cognitive functioning: the Maastricht study
title_short The relation of depression with structural brain abnormalities and cognitive functioning: the Maastricht study
title_sort relation of depression with structural brain abnormalities and cognitive functioning: the maastricht study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772903/
https://www.ncbi.nlm.nih.gov/pubmed/33634767
http://dx.doi.org/10.1017/S0033291721000222
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