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Cancer of the Liver and its Relationship with Diabetes mellitus

A high increase witnessed in type II diabetes mellitus (T2DM) globally has increasingly posed a serious threat to global increases in liver cancer with the association between diabetes mellitus type II and the survival rate in liver cancer patients showing unstable findings. An increase in the devel...

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Autores principales: Onikanni, Sunday Amos, Lawal, Bashir, Bakare, Oluwafemi Shittu, Ajiboye, Basiru Olaitan, Ojo, Oluwafemi Adeleke, Farasani, Abdullah, Kabrah, Saeed M, Batiha, Gaber El-Saber, Conte-Junior, Carlos Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772979/
https://www.ncbi.nlm.nih.gov/pubmed/36533882
http://dx.doi.org/10.1177/15330338221119743
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author Onikanni, Sunday Amos
Lawal, Bashir
Bakare, Oluwafemi Shittu
Ajiboye, Basiru Olaitan
Ojo, Oluwafemi Adeleke
Farasani, Abdullah
Kabrah, Saeed M
Batiha, Gaber El-Saber
Conte-Junior, Carlos Adam
author_facet Onikanni, Sunday Amos
Lawal, Bashir
Bakare, Oluwafemi Shittu
Ajiboye, Basiru Olaitan
Ojo, Oluwafemi Adeleke
Farasani, Abdullah
Kabrah, Saeed M
Batiha, Gaber El-Saber
Conte-Junior, Carlos Adam
author_sort Onikanni, Sunday Amos
collection PubMed
description A high increase witnessed in type II diabetes mellitus (T2DM) globally has increasingly posed a serious threat to global increases in liver cancer with the association between diabetes mellitus type II and the survival rate in liver cancer patients showing unstable findings. An increase in the development and progression of chronic liver disease from diabetes mellitus patients may be connected to cancer of the liver with several links such as Hepatitis B and C virus and heavy consumption of alcohol. The link between T2DM patients and liver cancer is centered on non-alcoholic fatty liver disease (NAFLD) which could be a serious threat globally if not clinically addressed. Several reports identified metformin treatment as linked to a lower risk of liver cancer prognosis while insulin treatment or sulphonylureas posed a serious threat. Mechanistically, the biological linkage between diabetes type II mellitus and liver cancer are still complex to understand with only the existence of a relationship between NAFLD and high level of energy intake and diabetes mellitus induces hepatic damage, increased liver weight thereby causes multiple pro-inflammatory cytokines that lead to the development of liver cancer. Therefore, this review gives an account of the pathophysiological importance of liver cancer position with T2DM, with the role of NAFLD as an important factor that bridges them.
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spelling pubmed-97729792022-12-23 Cancer of the Liver and its Relationship with Diabetes mellitus Onikanni, Sunday Amos Lawal, Bashir Bakare, Oluwafemi Shittu Ajiboye, Basiru Olaitan Ojo, Oluwafemi Adeleke Farasani, Abdullah Kabrah, Saeed M Batiha, Gaber El-Saber Conte-Junior, Carlos Adam Technol Cancer Res Treat Review A high increase witnessed in type II diabetes mellitus (T2DM) globally has increasingly posed a serious threat to global increases in liver cancer with the association between diabetes mellitus type II and the survival rate in liver cancer patients showing unstable findings. An increase in the development and progression of chronic liver disease from diabetes mellitus patients may be connected to cancer of the liver with several links such as Hepatitis B and C virus and heavy consumption of alcohol. The link between T2DM patients and liver cancer is centered on non-alcoholic fatty liver disease (NAFLD) which could be a serious threat globally if not clinically addressed. Several reports identified metformin treatment as linked to a lower risk of liver cancer prognosis while insulin treatment or sulphonylureas posed a serious threat. Mechanistically, the biological linkage between diabetes type II mellitus and liver cancer are still complex to understand with only the existence of a relationship between NAFLD and high level of energy intake and diabetes mellitus induces hepatic damage, increased liver weight thereby causes multiple pro-inflammatory cytokines that lead to the development of liver cancer. Therefore, this review gives an account of the pathophysiological importance of liver cancer position with T2DM, with the role of NAFLD as an important factor that bridges them. SAGE Publications 2022-12-19 /pmc/articles/PMC9772979/ /pubmed/36533882 http://dx.doi.org/10.1177/15330338221119743 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Onikanni, Sunday Amos
Lawal, Bashir
Bakare, Oluwafemi Shittu
Ajiboye, Basiru Olaitan
Ojo, Oluwafemi Adeleke
Farasani, Abdullah
Kabrah, Saeed M
Batiha, Gaber El-Saber
Conte-Junior, Carlos Adam
Cancer of the Liver and its Relationship with Diabetes mellitus
title Cancer of the Liver and its Relationship with Diabetes mellitus
title_full Cancer of the Liver and its Relationship with Diabetes mellitus
title_fullStr Cancer of the Liver and its Relationship with Diabetes mellitus
title_full_unstemmed Cancer of the Liver and its Relationship with Diabetes mellitus
title_short Cancer of the Liver and its Relationship with Diabetes mellitus
title_sort cancer of the liver and its relationship with diabetes mellitus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772979/
https://www.ncbi.nlm.nih.gov/pubmed/36533882
http://dx.doi.org/10.1177/15330338221119743
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