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Time above range for predicting the development of type 2 diabetes
AIM: To investigate the prognostic value of time range metrics, as measured by continuous glucose monitoring, with respect to the development of type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: A total of 499 persons without diabetes from the general population were followed-up for 5 years. Time...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772988/ https://www.ncbi.nlm.nih.gov/pubmed/36568777 http://dx.doi.org/10.3389/fpubh.2022.1005513 |
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author | Marco, Alejandra Pazos-Couselo, Marcos Moreno-Fernandez, Jesús Díez-Fernández, Ana Alonso-Sampedro, Manuela Fernández-Merino, Carmen Gonzalez-Quintela, Arturo Gude, Francisco |
author_facet | Marco, Alejandra Pazos-Couselo, Marcos Moreno-Fernandez, Jesús Díez-Fernández, Ana Alonso-Sampedro, Manuela Fernández-Merino, Carmen Gonzalez-Quintela, Arturo Gude, Francisco |
author_sort | Marco, Alejandra |
collection | PubMed |
description | AIM: To investigate the prognostic value of time range metrics, as measured by continuous glucose monitoring, with respect to the development of type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: A total of 499 persons without diabetes from the general population were followed-up for 5 years. Time range metrics were measured at the start and medical records were checked over the period study. RESULTS: Twenty-two subjects (8.3 per 1,000 person-years) developed T2D. After adjusting for age, gender, family history of diabetes, body mass index and glycated hemoglobin concentration, multivariate analysis revealed 'time above range' (TAR, i.e., with a plasma glucose concentration of >140 mg/dL) to be significantly associated with a greater risk (OR = 1.06, CI 1.01–1.11) of developing diabetes (AUC = 0.94, Brier = 0.035). CONCLUSIONS: Time above range provides additional information to that offered by glycated hemoglobin to identify patients at a higher risk of developing type 2 diabetes in a population-based study. |
format | Online Article Text |
id | pubmed-9772988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97729882022-12-23 Time above range for predicting the development of type 2 diabetes Marco, Alejandra Pazos-Couselo, Marcos Moreno-Fernandez, Jesús Díez-Fernández, Ana Alonso-Sampedro, Manuela Fernández-Merino, Carmen Gonzalez-Quintela, Arturo Gude, Francisco Front Public Health Public Health AIM: To investigate the prognostic value of time range metrics, as measured by continuous glucose monitoring, with respect to the development of type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: A total of 499 persons without diabetes from the general population were followed-up for 5 years. Time range metrics were measured at the start and medical records were checked over the period study. RESULTS: Twenty-two subjects (8.3 per 1,000 person-years) developed T2D. After adjusting for age, gender, family history of diabetes, body mass index and glycated hemoglobin concentration, multivariate analysis revealed 'time above range' (TAR, i.e., with a plasma glucose concentration of >140 mg/dL) to be significantly associated with a greater risk (OR = 1.06, CI 1.01–1.11) of developing diabetes (AUC = 0.94, Brier = 0.035). CONCLUSIONS: Time above range provides additional information to that offered by glycated hemoglobin to identify patients at a higher risk of developing type 2 diabetes in a population-based study. Frontiers Media S.A. 2022-12-08 /pmc/articles/PMC9772988/ /pubmed/36568777 http://dx.doi.org/10.3389/fpubh.2022.1005513 Text en Copyright © 2022 Marco, Pazos-Couselo, Moreno-Fernandez, Díez-Fernández, Alonso-Sampedro, Fernández-Merino, Gonzalez-Quintela and Gude. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Marco, Alejandra Pazos-Couselo, Marcos Moreno-Fernandez, Jesús Díez-Fernández, Ana Alonso-Sampedro, Manuela Fernández-Merino, Carmen Gonzalez-Quintela, Arturo Gude, Francisco Time above range for predicting the development of type 2 diabetes |
title | Time above range for predicting the development of type 2 diabetes |
title_full | Time above range for predicting the development of type 2 diabetes |
title_fullStr | Time above range for predicting the development of type 2 diabetes |
title_full_unstemmed | Time above range for predicting the development of type 2 diabetes |
title_short | Time above range for predicting the development of type 2 diabetes |
title_sort | time above range for predicting the development of type 2 diabetes |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772988/ https://www.ncbi.nlm.nih.gov/pubmed/36568777 http://dx.doi.org/10.3389/fpubh.2022.1005513 |
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