Cargando…

The longer-term effects of IVF on offspring from childhood to adolescence

It is well established that there are increased pregnancy-related complications for a woman who conceives through assisted reproductive treatment (ART). Furthermore, it is known that the risk to the child born is greater, believed to be related to prematurity and growth restriction. Studies have als...

Descripción completa

Detalles Bibliográficos
Autores principales: Hart, R. J., Wijs, L. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773093/
https://www.ncbi.nlm.nih.gov/pubmed/36570043
http://dx.doi.org/10.3389/frph.2022.1045762
_version_ 1784855124020035584
author Hart, R. J.
Wijs, L. A.
author_facet Hart, R. J.
Wijs, L. A.
author_sort Hart, R. J.
collection PubMed
description It is well established that there are increased pregnancy-related complications for a woman who conceives through assisted reproductive treatment (ART). Furthermore, it is known that the risk to the child born is greater, believed to be related to prematurity and growth restriction. Studies have also reported epigenetic changes in the DNA of offspring conceived through ART. In addition, it is believed that they have a greater risk of congenital malformations, although some of these risks may relate to underlying infertility, rather than the ART treatment per se. As a result, it may be expected that there is a greater risk to the longer-term health of the child who is born from ART; however, evidence about the long-term health of children conceived through ART is reassuring. Even though, it is recognised that many of the studies in this field come with limitations. Low numbers of participants is one of the major limitations, which makes subgroup analyses for diverse types of ART, or diverse types of infertility, not feasible. Furthermore, studies are often limited by short follow-up periods because of the difficulty and costs involved in longitudinal study designs. In addition, the rapid changes over time in ART limit the generalisability and significance of long-term findings. Well-designed studies investigating the long-term health outcomes of ART-conceived offspring and the potential influences of various aspects of the ART procedure, as well as studies of the potential underlying epigenetic mechanisms, are imperative. Furthermore, conclusions from childhood hospitalisation data from the United Kingdom, the long-term follow-up and quality of life study from researchers in Melbourne, and the data published from the Western Australian Growing Up Healthy Study will go a long way to help reassure current and prospective parents who may require ART to conceive.
format Online
Article
Text
id pubmed-9773093
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-97730932022-12-23 The longer-term effects of IVF on offspring from childhood to adolescence Hart, R. J. Wijs, L. A. Front Reprod Health Reproductive Health It is well established that there are increased pregnancy-related complications for a woman who conceives through assisted reproductive treatment (ART). Furthermore, it is known that the risk to the child born is greater, believed to be related to prematurity and growth restriction. Studies have also reported epigenetic changes in the DNA of offspring conceived through ART. In addition, it is believed that they have a greater risk of congenital malformations, although some of these risks may relate to underlying infertility, rather than the ART treatment per se. As a result, it may be expected that there is a greater risk to the longer-term health of the child who is born from ART; however, evidence about the long-term health of children conceived through ART is reassuring. Even though, it is recognised that many of the studies in this field come with limitations. Low numbers of participants is one of the major limitations, which makes subgroup analyses for diverse types of ART, or diverse types of infertility, not feasible. Furthermore, studies are often limited by short follow-up periods because of the difficulty and costs involved in longitudinal study designs. In addition, the rapid changes over time in ART limit the generalisability and significance of long-term findings. Well-designed studies investigating the long-term health outcomes of ART-conceived offspring and the potential influences of various aspects of the ART procedure, as well as studies of the potential underlying epigenetic mechanisms, are imperative. Furthermore, conclusions from childhood hospitalisation data from the United Kingdom, the long-term follow-up and quality of life study from researchers in Melbourne, and the data published from the Western Australian Growing Up Healthy Study will go a long way to help reassure current and prospective parents who may require ART to conceive. Frontiers Media S.A. 2022-12-08 /pmc/articles/PMC9773093/ /pubmed/36570043 http://dx.doi.org/10.3389/frph.2022.1045762 Text en © 2022 Hart and Wijs. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Reproductive Health
Hart, R. J.
Wijs, L. A.
The longer-term effects of IVF on offspring from childhood to adolescence
title The longer-term effects of IVF on offspring from childhood to adolescence
title_full The longer-term effects of IVF on offspring from childhood to adolescence
title_fullStr The longer-term effects of IVF on offspring from childhood to adolescence
title_full_unstemmed The longer-term effects of IVF on offspring from childhood to adolescence
title_short The longer-term effects of IVF on offspring from childhood to adolescence
title_sort longer-term effects of ivf on offspring from childhood to adolescence
topic Reproductive Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773093/
https://www.ncbi.nlm.nih.gov/pubmed/36570043
http://dx.doi.org/10.3389/frph.2022.1045762
work_keys_str_mv AT hartrj thelongertermeffectsofivfonoffspringfromchildhoodtoadolescence
AT wijsla thelongertermeffectsofivfonoffspringfromchildhoodtoadolescence
AT hartrj longertermeffectsofivfonoffspringfromchildhoodtoadolescence
AT wijsla longertermeffectsofivfonoffspringfromchildhoodtoadolescence