Cargando…

Detection of FeChPV in a cat shelter outbreak of upper respiratory tract disease in China

Feline parvovirus often causes a fatal infectious disease and has a serious impact on domestic cats and wild felines. Feline chaphamaparvovirus (FeChPV) is a novel type of feline parvovirus that has been successively identified in Canada, Italy, and Turkey. The prevalence and pathogenicity of FeChPV...

Descripción completa

Detalles Bibliográficos
Autores principales: Hao, Xiangqi, Li, Yanchao, Chen, Bo, Wang, Hanhong, Wang, Xinrui, Xiao, Xiangyu, Zhou, Pei, Li, Shoujun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773189/
https://www.ncbi.nlm.nih.gov/pubmed/36569076
http://dx.doi.org/10.3389/fmicb.2022.1064747
_version_ 1784855146421813248
author Hao, Xiangqi
Li, Yanchao
Chen, Bo
Wang, Hanhong
Wang, Xinrui
Xiao, Xiangyu
Zhou, Pei
Li, Shoujun
author_facet Hao, Xiangqi
Li, Yanchao
Chen, Bo
Wang, Hanhong
Wang, Xinrui
Xiao, Xiangyu
Zhou, Pei
Li, Shoujun
author_sort Hao, Xiangqi
collection PubMed
description Feline parvovirus often causes a fatal infectious disease and has a serious impact on domestic cats and wild felines. Feline chaphamaparvovirus (FeChPV) is a novel type of feline parvovirus that has been successively identified in Canada, Italy, and Turkey. The prevalence and pathogenicity of FeChPV in other regions is still unknown. In this study, we recorded the detection of FeChPV in a cat shelter in China. A high prevalence (81.08%, 30/37) of FeChPV was detected in cats with symptoms of upper respiratory tract disease (URTD) in this cat shelter. Multiple pathogen testing indicated high coinfection rates of 80% (24/30) with other common viruses in FeChPV-positive cats. Analyses of the necropsy and histopathological findings revealed severe lymphadenitis, encephalitis, and viral DNA in several tissues (including brain) of the deceased cat. Finally, we obtained nearly full-length genomes of four strains with 98.4%~98.6% homology with previously reported genomes. Notably, VP1 proteins showed seven unique amino acid mutations, while NS1 proteins carried eight mutations. In the evolutionary tree based on VP1 and NS1, the sequences clustered in a large branch with Italian and Canadian FeChPV strains. Given the possible association of FeChPV with URTD, further studies are necessary to evaluate the pathogenicity and epidemiological characteristics of this novel feline pathogen.
format Online
Article
Text
id pubmed-9773189
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-97731892022-12-23 Detection of FeChPV in a cat shelter outbreak of upper respiratory tract disease in China Hao, Xiangqi Li, Yanchao Chen, Bo Wang, Hanhong Wang, Xinrui Xiao, Xiangyu Zhou, Pei Li, Shoujun Front Microbiol Microbiology Feline parvovirus often causes a fatal infectious disease and has a serious impact on domestic cats and wild felines. Feline chaphamaparvovirus (FeChPV) is a novel type of feline parvovirus that has been successively identified in Canada, Italy, and Turkey. The prevalence and pathogenicity of FeChPV in other regions is still unknown. In this study, we recorded the detection of FeChPV in a cat shelter in China. A high prevalence (81.08%, 30/37) of FeChPV was detected in cats with symptoms of upper respiratory tract disease (URTD) in this cat shelter. Multiple pathogen testing indicated high coinfection rates of 80% (24/30) with other common viruses in FeChPV-positive cats. Analyses of the necropsy and histopathological findings revealed severe lymphadenitis, encephalitis, and viral DNA in several tissues (including brain) of the deceased cat. Finally, we obtained nearly full-length genomes of four strains with 98.4%~98.6% homology with previously reported genomes. Notably, VP1 proteins showed seven unique amino acid mutations, while NS1 proteins carried eight mutations. In the evolutionary tree based on VP1 and NS1, the sequences clustered in a large branch with Italian and Canadian FeChPV strains. Given the possible association of FeChPV with URTD, further studies are necessary to evaluate the pathogenicity and epidemiological characteristics of this novel feline pathogen. Frontiers Media S.A. 2022-12-08 /pmc/articles/PMC9773189/ /pubmed/36569076 http://dx.doi.org/10.3389/fmicb.2022.1064747 Text en Copyright © 2022 Hao, Li, Chen, Wang, Wang, Xiao, Zhou and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Hao, Xiangqi
Li, Yanchao
Chen, Bo
Wang, Hanhong
Wang, Xinrui
Xiao, Xiangyu
Zhou, Pei
Li, Shoujun
Detection of FeChPV in a cat shelter outbreak of upper respiratory tract disease in China
title Detection of FeChPV in a cat shelter outbreak of upper respiratory tract disease in China
title_full Detection of FeChPV in a cat shelter outbreak of upper respiratory tract disease in China
title_fullStr Detection of FeChPV in a cat shelter outbreak of upper respiratory tract disease in China
title_full_unstemmed Detection of FeChPV in a cat shelter outbreak of upper respiratory tract disease in China
title_short Detection of FeChPV in a cat shelter outbreak of upper respiratory tract disease in China
title_sort detection of fechpv in a cat shelter outbreak of upper respiratory tract disease in china
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773189/
https://www.ncbi.nlm.nih.gov/pubmed/36569076
http://dx.doi.org/10.3389/fmicb.2022.1064747
work_keys_str_mv AT haoxiangqi detectionoffechpvinacatshelteroutbreakofupperrespiratorytractdiseaseinchina
AT liyanchao detectionoffechpvinacatshelteroutbreakofupperrespiratorytractdiseaseinchina
AT chenbo detectionoffechpvinacatshelteroutbreakofupperrespiratorytractdiseaseinchina
AT wanghanhong detectionoffechpvinacatshelteroutbreakofupperrespiratorytractdiseaseinchina
AT wangxinrui detectionoffechpvinacatshelteroutbreakofupperrespiratorytractdiseaseinchina
AT xiaoxiangyu detectionoffechpvinacatshelteroutbreakofupperrespiratorytractdiseaseinchina
AT zhoupei detectionoffechpvinacatshelteroutbreakofupperrespiratorytractdiseaseinchina
AT lishoujun detectionoffechpvinacatshelteroutbreakofupperrespiratorytractdiseaseinchina