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AAV8-mediated sVEGFR2 and sVEGFR3 gene therapy combined with chemotherapy reduces the growth and microvasculature of human ovarian cancer and prolongs the survival in mice

BACKGROUND: Vascular endothelial growth factors (VEGFs) are major regulators of intratumoral angiogenesis in ovarian cancer (OVCA). Overexpression of VEGFs is associated with increased tumor growth and metastatic tendency and VEGF-targeting therapies are thus considered as potential treatments for O...

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Detalles Bibliográficos
Autores principales:	Kujala, Anni, Valkonen, Elina, Sallinen, Hanna, Tuppurainen, Laura, Laakso, Hanne, Ylä-Herttuala, Elias, Liimatainen, Timo, Kujala, Jouni, Jokelainen, Otto, Sironen, Reijo, Anttila, Maarit, Ylä-Herttuala, Seppo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773272/ https://www.ncbi.nlm.nih.gov/pubmed/36569136 http://dx.doi.org/10.3389/fmed.2022.1018208

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