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Development and validation of a mobile application based on a machine learning model to aid in predicting dosage of vitamin K antagonists among Indian patients post mechanical heart valve replacement
Patients who undergo heart valve replacements with mechanical valves need to take Vitamin K Antagonists (VKA) drugs (Warfarin, Nicoumalone) which has got a very narrow therapeutic range and needs very close monitoring using PT-INR. Accessibility to physicians to titrate drugs doses is a major proble...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773288/ https://www.ncbi.nlm.nih.gov/pubmed/36243102 http://dx.doi.org/10.1016/j.ihj.2022.10.002 |
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author | Amruthlal, M. Devika, S. Krishnan, Vignesh Ameer Suhail, P.A. Menon, Aravind K. Thomas, Alan Thomas, Manu Sanjay, G. Lakshmi Kanth, L.R. Jeemon, P. Jose, Jimmy Harikrishnan, S. |
author_facet | Amruthlal, M. Devika, S. Krishnan, Vignesh Ameer Suhail, P.A. Menon, Aravind K. Thomas, Alan Thomas, Manu Sanjay, G. Lakshmi Kanth, L.R. Jeemon, P. Jose, Jimmy Harikrishnan, S. |
author_sort | Amruthlal, M. |
collection | PubMed |
description | Patients who undergo heart valve replacements with mechanical valves need to take Vitamin K Antagonists (VKA) drugs (Warfarin, Nicoumalone) which has got a very narrow therapeutic range and needs very close monitoring using PT-INR. Accessibility to physicians to titrate drugs doses is a major problem in low-middle income countries (LMIC) like India. Our work was aimed at predicting the maintenance dosage of these drugs, using the de-identified medical data collected from patients attending an INR Clinic in South India. We used artificial intelligence (AI) - machine learning to develop the algorithm. A Support Vector Machine (SVM) regression model was built to predict the maintenance dosage of warfarin, who have stable INR values between 2.0 and 4.0. We developed a simple user friendly android mobile application for patients to use the algorithm to predict the doses. The algorithm generated drug doses in 1100 patients were compared to cardiologist prescribed doses and found to have an excellent correlation. |
format | Online Article Text |
id | pubmed-9773288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-97732882022-12-23 Development and validation of a mobile application based on a machine learning model to aid in predicting dosage of vitamin K antagonists among Indian patients post mechanical heart valve replacement Amruthlal, M. Devika, S. Krishnan, Vignesh Ameer Suhail, P.A. Menon, Aravind K. Thomas, Alan Thomas, Manu Sanjay, G. Lakshmi Kanth, L.R. Jeemon, P. Jose, Jimmy Harikrishnan, S. Indian Heart J Original Article Patients who undergo heart valve replacements with mechanical valves need to take Vitamin K Antagonists (VKA) drugs (Warfarin, Nicoumalone) which has got a very narrow therapeutic range and needs very close monitoring using PT-INR. Accessibility to physicians to titrate drugs doses is a major problem in low-middle income countries (LMIC) like India. Our work was aimed at predicting the maintenance dosage of these drugs, using the de-identified medical data collected from patients attending an INR Clinic in South India. We used artificial intelligence (AI) - machine learning to develop the algorithm. A Support Vector Machine (SVM) regression model was built to predict the maintenance dosage of warfarin, who have stable INR values between 2.0 and 4.0. We developed a simple user friendly android mobile application for patients to use the algorithm to predict the doses. The algorithm generated drug doses in 1100 patients were compared to cardiologist prescribed doses and found to have an excellent correlation. Elsevier 2022 2022-10-13 /pmc/articles/PMC9773288/ /pubmed/36243102 http://dx.doi.org/10.1016/j.ihj.2022.10.002 Text en © 2022 Cardiological Society of India. Published by Elsevier, a division of RELX India, Pvt. Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Amruthlal, M. Devika, S. Krishnan, Vignesh Ameer Suhail, P.A. Menon, Aravind K. Thomas, Alan Thomas, Manu Sanjay, G. Lakshmi Kanth, L.R. Jeemon, P. Jose, Jimmy Harikrishnan, S. Development and validation of a mobile application based on a machine learning model to aid in predicting dosage of vitamin K antagonists among Indian patients post mechanical heart valve replacement |
title | Development and validation of a mobile application based on a machine learning model to aid in predicting dosage of vitamin K antagonists among Indian patients post mechanical heart valve replacement |
title_full | Development and validation of a mobile application based on a machine learning model to aid in predicting dosage of vitamin K antagonists among Indian patients post mechanical heart valve replacement |
title_fullStr | Development and validation of a mobile application based on a machine learning model to aid in predicting dosage of vitamin K antagonists among Indian patients post mechanical heart valve replacement |
title_full_unstemmed | Development and validation of a mobile application based on a machine learning model to aid in predicting dosage of vitamin K antagonists among Indian patients post mechanical heart valve replacement |
title_short | Development and validation of a mobile application based on a machine learning model to aid in predicting dosage of vitamin K antagonists among Indian patients post mechanical heart valve replacement |
title_sort | development and validation of a mobile application based on a machine learning model to aid in predicting dosage of vitamin k antagonists among indian patients post mechanical heart valve replacement |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773288/ https://www.ncbi.nlm.nih.gov/pubmed/36243102 http://dx.doi.org/10.1016/j.ihj.2022.10.002 |
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