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Micelle and Nanotape Formation of Benzene Tricarboxamide Analogues with Selective Cancer Cell Cytotoxicity
[Image: see text] Analogues of benzene-1,3,5-tricarboxamide bearing combinations of different alkyl chains (dodecyl to octadecyl) and ester-linked PEG (polyethylene glycol) chains are shown to self-assemble into either micelles or nanotapes in aqueous solution, depending on the architecture (number...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773333/ https://www.ncbi.nlm.nih.gov/pubmed/36570178 http://dx.doi.org/10.1021/acsomega.2c05940 |
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author | Aljuaid, Nada Seitsonen, Jani Ruokolainen, Janne Greco, Francesca Hamley, Ian W. |
author_facet | Aljuaid, Nada Seitsonen, Jani Ruokolainen, Janne Greco, Francesca Hamley, Ian W. |
author_sort | Aljuaid, Nada |
collection | PubMed |
description | [Image: see text] Analogues of benzene-1,3,5-tricarboxamide bearing combinations of different alkyl chains (dodecyl to octadecyl) and ester-linked PEG (polyethylene glycol) chains are shown to self-assemble into either micelles or nanotapes in aqueous solution, depending on the architecture (number of alkyl vs PEG chains). The cytotoxicity to cells is selectively greater for breast cancer cells than fibroblast controls in a dose-dependent manner. The compounds show strong stability, retaining their self-assembled structures at low pH (relevant to acidic tumor conditions) and in buffer and cell culture media. |
format | Online Article Text |
id | pubmed-9773333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-97733332022-12-23 Micelle and Nanotape Formation of Benzene Tricarboxamide Analogues with Selective Cancer Cell Cytotoxicity Aljuaid, Nada Seitsonen, Jani Ruokolainen, Janne Greco, Francesca Hamley, Ian W. ACS Omega [Image: see text] Analogues of benzene-1,3,5-tricarboxamide bearing combinations of different alkyl chains (dodecyl to octadecyl) and ester-linked PEG (polyethylene glycol) chains are shown to self-assemble into either micelles or nanotapes in aqueous solution, depending on the architecture (number of alkyl vs PEG chains). The cytotoxicity to cells is selectively greater for breast cancer cells than fibroblast controls in a dose-dependent manner. The compounds show strong stability, retaining their self-assembled structures at low pH (relevant to acidic tumor conditions) and in buffer and cell culture media. American Chemical Society 2022-12-07 /pmc/articles/PMC9773333/ /pubmed/36570178 http://dx.doi.org/10.1021/acsomega.2c05940 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Aljuaid, Nada Seitsonen, Jani Ruokolainen, Janne Greco, Francesca Hamley, Ian W. Micelle and Nanotape Formation of Benzene Tricarboxamide Analogues with Selective Cancer Cell Cytotoxicity |
title | Micelle and Nanotape
Formation of Benzene Tricarboxamide
Analogues with Selective Cancer Cell Cytotoxicity |
title_full | Micelle and Nanotape
Formation of Benzene Tricarboxamide
Analogues with Selective Cancer Cell Cytotoxicity |
title_fullStr | Micelle and Nanotape
Formation of Benzene Tricarboxamide
Analogues with Selective Cancer Cell Cytotoxicity |
title_full_unstemmed | Micelle and Nanotape
Formation of Benzene Tricarboxamide
Analogues with Selective Cancer Cell Cytotoxicity |
title_short | Micelle and Nanotape
Formation of Benzene Tricarboxamide
Analogues with Selective Cancer Cell Cytotoxicity |
title_sort | micelle and nanotape
formation of benzene tricarboxamide
analogues with selective cancer cell cytotoxicity |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773333/ https://www.ncbi.nlm.nih.gov/pubmed/36570178 http://dx.doi.org/10.1021/acsomega.2c05940 |
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