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Investigation of d-Amino Acid-Based Surfactants and Nanocomposites with Gold and Silica Nanoparticles as against Multidrug-Resistant Bacteria Agents
[Image: see text] d-amino acid-based surfactants (d-AASs) were synthesized and their antimicrobial activity was evaluated. N-α-lauroyl-d-arginine ethyl ester hydrochloride (d-LAE), d-proline dodecyl ester (d-PD), and d-alanine dodecyl ester (d-AD) were found to have antibacterial activity against bo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773340/ https://www.ncbi.nlm.nih.gov/pubmed/36570237 http://dx.doi.org/10.1021/acsomega.2c04220 |
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author | Shim, Jae Ho Gwak, Sungduk Ahn, Byung Kook Han, Hogyu Hong, Yeonsun Shin, Ok Sarah |
author_facet | Shim, Jae Ho Gwak, Sungduk Ahn, Byung Kook Han, Hogyu Hong, Yeonsun Shin, Ok Sarah |
author_sort | Shim, Jae Ho |
collection | PubMed |
description | [Image: see text] d-amino acid-based surfactants (d-AASs) were synthesized and their antimicrobial activity was evaluated. N-α-lauroyl-d-arginine ethyl ester hydrochloride (d-LAE), d-proline dodecyl ester (d-PD), and d-alanine dodecyl ester (d-AD) were found to have antibacterial activity against both Gram-positive and -negative bacteria, but less efficacy against Gram-negative bacteria. For these reasons, combining antimicrobial agents with nanoparticles is a promising technique for improving their antibacterial properties to eliminate drug-resistant pathogens. d-LAE coated on gold (AuNP) and silica (SiNP) nanoparticles has more efficient antibacterial activity than that of d-LAE alone. However, unlike d-LAE, d-PD has enhanced antibacterial activity upon being coated on AuNP. The antibacterial d-AASs and their nanocomposites with nanoparticles were synthesized in an environmentally friendly manner and are expected to be valuable new antimicrobial agents against multidrug-resistant (MDR) pathogens. |
format | Online Article Text |
id | pubmed-9773340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-97733402022-12-23 Investigation of d-Amino Acid-Based Surfactants and Nanocomposites with Gold and Silica Nanoparticles as against Multidrug-Resistant Bacteria Agents Shim, Jae Ho Gwak, Sungduk Ahn, Byung Kook Han, Hogyu Hong, Yeonsun Shin, Ok Sarah ACS Omega [Image: see text] d-amino acid-based surfactants (d-AASs) were synthesized and their antimicrobial activity was evaluated. N-α-lauroyl-d-arginine ethyl ester hydrochloride (d-LAE), d-proline dodecyl ester (d-PD), and d-alanine dodecyl ester (d-AD) were found to have antibacterial activity against both Gram-positive and -negative bacteria, but less efficacy against Gram-negative bacteria. For these reasons, combining antimicrobial agents with nanoparticles is a promising technique for improving their antibacterial properties to eliminate drug-resistant pathogens. d-LAE coated on gold (AuNP) and silica (SiNP) nanoparticles has more efficient antibacterial activity than that of d-LAE alone. However, unlike d-LAE, d-PD has enhanced antibacterial activity upon being coated on AuNP. The antibacterial d-AASs and their nanocomposites with nanoparticles were synthesized in an environmentally friendly manner and are expected to be valuable new antimicrobial agents against multidrug-resistant (MDR) pathogens. American Chemical Society 2022-12-08 /pmc/articles/PMC9773340/ /pubmed/36570237 http://dx.doi.org/10.1021/acsomega.2c04220 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Shim, Jae Ho Gwak, Sungduk Ahn, Byung Kook Han, Hogyu Hong, Yeonsun Shin, Ok Sarah Investigation of d-Amino Acid-Based Surfactants and Nanocomposites with Gold and Silica Nanoparticles as against Multidrug-Resistant Bacteria Agents |
title | Investigation of d-Amino Acid-Based
Surfactants and Nanocomposites with Gold and Silica Nanoparticles
as against Multidrug-Resistant Bacteria Agents |
title_full | Investigation of d-Amino Acid-Based
Surfactants and Nanocomposites with Gold and Silica Nanoparticles
as against Multidrug-Resistant Bacteria Agents |
title_fullStr | Investigation of d-Amino Acid-Based
Surfactants and Nanocomposites with Gold and Silica Nanoparticles
as against Multidrug-Resistant Bacteria Agents |
title_full_unstemmed | Investigation of d-Amino Acid-Based
Surfactants and Nanocomposites with Gold and Silica Nanoparticles
as against Multidrug-Resistant Bacteria Agents |
title_short | Investigation of d-Amino Acid-Based
Surfactants and Nanocomposites with Gold and Silica Nanoparticles
as against Multidrug-Resistant Bacteria Agents |
title_sort | investigation of d-amino acid-based
surfactants and nanocomposites with gold and silica nanoparticles
as against multidrug-resistant bacteria agents |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773340/ https://www.ncbi.nlm.nih.gov/pubmed/36570237 http://dx.doi.org/10.1021/acsomega.2c04220 |
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