Cargando…
Causal association between systemic lupus erythematosus and the risk of dementia: A Mendelian randomization study
INTRODUCTION: It is well-documented that systemic lupus erythematosus (SLE) is associated with dementia. However, the genetic causality of this association remains unclear. Mendelian randomization (MR) was used to investigate the potential causal relationship between SLE and dementia risk in the cur...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773372/ https://www.ncbi.nlm.nih.gov/pubmed/36569847 http://dx.doi.org/10.3389/fimmu.2022.1063110 |
_version_ | 1784855180257263616 |
---|---|
author | Jin, Tianyu Huang, Wei Cao, Fangzheng Yu, Xinyue Guo, Shunyuan Ying, Zhenhua Xu, Chao |
author_facet | Jin, Tianyu Huang, Wei Cao, Fangzheng Yu, Xinyue Guo, Shunyuan Ying, Zhenhua Xu, Chao |
author_sort | Jin, Tianyu |
collection | PubMed |
description | INTRODUCTION: It is well-documented that systemic lupus erythematosus (SLE) is associated with dementia. However, the genetic causality of this association remains unclear. Mendelian randomization (MR) was used to investigate the potential causal relationship between SLE and dementia risk in the current study. METHODS: We selected 45 single nucleotide polymorphisms (SNPs) associated with SLE from publicly available genome-wide association studies (GWAS). Summary level statistics were obtained from the dementia GWAS database. MR estimates were performed using the inverse variance weighted (IVW) method, MR-Egger method and weighted median (WM) method. Cochran’s Q test, the intercept of MR-Egger, MR-Pleiotropy Residual Sum and Outlier method, leave-one-out analysis and funnel plot were applied for sensitivity analyses. RESULTS: No significant causal association was found between SLE and any type of dementia, including Alzheimer’s disease, vascular dementia, frontotemporal dementia, and dementia with Lewy bodies. These findings were robust across several sensitivity analyses. CONCLUSION: Overall, our findings do not support a causal association between SLE and dementia risk. |
format | Online Article Text |
id | pubmed-9773372 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97733722022-12-23 Causal association between systemic lupus erythematosus and the risk of dementia: A Mendelian randomization study Jin, Tianyu Huang, Wei Cao, Fangzheng Yu, Xinyue Guo, Shunyuan Ying, Zhenhua Xu, Chao Front Immunol Immunology INTRODUCTION: It is well-documented that systemic lupus erythematosus (SLE) is associated with dementia. However, the genetic causality of this association remains unclear. Mendelian randomization (MR) was used to investigate the potential causal relationship between SLE and dementia risk in the current study. METHODS: We selected 45 single nucleotide polymorphisms (SNPs) associated with SLE from publicly available genome-wide association studies (GWAS). Summary level statistics were obtained from the dementia GWAS database. MR estimates were performed using the inverse variance weighted (IVW) method, MR-Egger method and weighted median (WM) method. Cochran’s Q test, the intercept of MR-Egger, MR-Pleiotropy Residual Sum and Outlier method, leave-one-out analysis and funnel plot were applied for sensitivity analyses. RESULTS: No significant causal association was found between SLE and any type of dementia, including Alzheimer’s disease, vascular dementia, frontotemporal dementia, and dementia with Lewy bodies. These findings were robust across several sensitivity analyses. CONCLUSION: Overall, our findings do not support a causal association between SLE and dementia risk. Frontiers Media S.A. 2022-12-08 /pmc/articles/PMC9773372/ /pubmed/36569847 http://dx.doi.org/10.3389/fimmu.2022.1063110 Text en Copyright © 2022 Jin, Huang, Cao, Yu, Guo, Ying and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Jin, Tianyu Huang, Wei Cao, Fangzheng Yu, Xinyue Guo, Shunyuan Ying, Zhenhua Xu, Chao Causal association between systemic lupus erythematosus and the risk of dementia: A Mendelian randomization study |
title | Causal association between systemic lupus erythematosus and the risk of dementia: A Mendelian randomization study |
title_full | Causal association between systemic lupus erythematosus and the risk of dementia: A Mendelian randomization study |
title_fullStr | Causal association between systemic lupus erythematosus and the risk of dementia: A Mendelian randomization study |
title_full_unstemmed | Causal association between systemic lupus erythematosus and the risk of dementia: A Mendelian randomization study |
title_short | Causal association between systemic lupus erythematosus and the risk of dementia: A Mendelian randomization study |
title_sort | causal association between systemic lupus erythematosus and the risk of dementia: a mendelian randomization study |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773372/ https://www.ncbi.nlm.nih.gov/pubmed/36569847 http://dx.doi.org/10.3389/fimmu.2022.1063110 |
work_keys_str_mv | AT jintianyu causalassociationbetweensystemiclupuserythematosusandtheriskofdementiaamendelianrandomizationstudy AT huangwei causalassociationbetweensystemiclupuserythematosusandtheriskofdementiaamendelianrandomizationstudy AT caofangzheng causalassociationbetweensystemiclupuserythematosusandtheriskofdementiaamendelianrandomizationstudy AT yuxinyue causalassociationbetweensystemiclupuserythematosusandtheriskofdementiaamendelianrandomizationstudy AT guoshunyuan causalassociationbetweensystemiclupuserythematosusandtheriskofdementiaamendelianrandomizationstudy AT yingzhenhua causalassociationbetweensystemiclupuserythematosusandtheriskofdementiaamendelianrandomizationstudy AT xuchao causalassociationbetweensystemiclupuserythematosusandtheriskofdementiaamendelianrandomizationstudy |