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Time-locked auditory cortical responses in the high-gamma band: A window into primary auditory cortex

Primary auditory cortex is a critical stage in the human auditory pathway, a gateway between subcortical and higher-level cortical areas. Receiving the output of all subcortical processing, it sends its output on to higher-level cortex. Non-invasive physiological recordings of primary auditory corte...

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Autores principales: Simon, Jonathan Z., Commuri, Vrishab, Kulasingham, Joshua P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773383/
https://www.ncbi.nlm.nih.gov/pubmed/36570848
http://dx.doi.org/10.3389/fnins.2022.1075369
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author Simon, Jonathan Z.
Commuri, Vrishab
Kulasingham, Joshua P.
author_facet Simon, Jonathan Z.
Commuri, Vrishab
Kulasingham, Joshua P.
author_sort Simon, Jonathan Z.
collection PubMed
description Primary auditory cortex is a critical stage in the human auditory pathway, a gateway between subcortical and higher-level cortical areas. Receiving the output of all subcortical processing, it sends its output on to higher-level cortex. Non-invasive physiological recordings of primary auditory cortex using electroencephalography (EEG) and magnetoencephalography (MEG), however, may not have sufficient specificity to separate responses generated in primary auditory cortex from those generated in underlying subcortical areas or neighboring cortical areas. This limitation is important for investigations of effects of top-down processing (e.g., selective-attention-based) on primary auditory cortex: higher-level areas are known to be strongly influenced by top-down processes, but subcortical areas are often assumed to perform strictly bottom-up processing. Fortunately, recent advances have made it easier to isolate the neural activity of primary auditory cortex from other areas. In this perspective, we focus on time-locked responses to stimulus features in the high gamma band (70–150 Hz) and with early cortical latency (∼40 ms), intermediate between subcortical and higher-level areas. We review recent findings from physiological studies employing either repeated simple sounds or continuous speech, obtaining either a frequency following response (FFR) or temporal response function (TRF). The potential roles of top-down processing are underscored, and comparisons with invasive intracranial EEG (iEEG) and animal model recordings are made. We argue that MEG studies employing continuous speech stimuli may offer particular benefits, in that only a few minutes of speech generates robust high gamma responses from bilateral primary auditory cortex, and without measurable interference from subcortical or higher-level areas.
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spelling pubmed-97733832022-12-23 Time-locked auditory cortical responses in the high-gamma band: A window into primary auditory cortex Simon, Jonathan Z. Commuri, Vrishab Kulasingham, Joshua P. Front Neurosci Neuroscience Primary auditory cortex is a critical stage in the human auditory pathway, a gateway between subcortical and higher-level cortical areas. Receiving the output of all subcortical processing, it sends its output on to higher-level cortex. Non-invasive physiological recordings of primary auditory cortex using electroencephalography (EEG) and magnetoencephalography (MEG), however, may not have sufficient specificity to separate responses generated in primary auditory cortex from those generated in underlying subcortical areas or neighboring cortical areas. This limitation is important for investigations of effects of top-down processing (e.g., selective-attention-based) on primary auditory cortex: higher-level areas are known to be strongly influenced by top-down processes, but subcortical areas are often assumed to perform strictly bottom-up processing. Fortunately, recent advances have made it easier to isolate the neural activity of primary auditory cortex from other areas. In this perspective, we focus on time-locked responses to stimulus features in the high gamma band (70–150 Hz) and with early cortical latency (∼40 ms), intermediate between subcortical and higher-level areas. We review recent findings from physiological studies employing either repeated simple sounds or continuous speech, obtaining either a frequency following response (FFR) or temporal response function (TRF). The potential roles of top-down processing are underscored, and comparisons with invasive intracranial EEG (iEEG) and animal model recordings are made. We argue that MEG studies employing continuous speech stimuli may offer particular benefits, in that only a few minutes of speech generates robust high gamma responses from bilateral primary auditory cortex, and without measurable interference from subcortical or higher-level areas. Frontiers Media S.A. 2022-12-08 /pmc/articles/PMC9773383/ /pubmed/36570848 http://dx.doi.org/10.3389/fnins.2022.1075369 Text en Copyright © 2022 Simon, Commuri and Kulasingham. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Simon, Jonathan Z.
Commuri, Vrishab
Kulasingham, Joshua P.
Time-locked auditory cortical responses in the high-gamma band: A window into primary auditory cortex
title Time-locked auditory cortical responses in the high-gamma band: A window into primary auditory cortex
title_full Time-locked auditory cortical responses in the high-gamma band: A window into primary auditory cortex
title_fullStr Time-locked auditory cortical responses in the high-gamma band: A window into primary auditory cortex
title_full_unstemmed Time-locked auditory cortical responses in the high-gamma band: A window into primary auditory cortex
title_short Time-locked auditory cortical responses in the high-gamma band: A window into primary auditory cortex
title_sort time-locked auditory cortical responses in the high-gamma band: a window into primary auditory cortex
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773383/
https://www.ncbi.nlm.nih.gov/pubmed/36570848
http://dx.doi.org/10.3389/fnins.2022.1075369
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