Cargando…

Attitudes and values among the Swedish general public to using human embryonic stem cells for medical treatment

BACKGROUND: The use of human embryonic stem cells (ES cells) for the development of medical therapies is surrounded with moral concerns. The aim of this study was to assess the public’s attitudes toward the use of ES cells for treatment of Parkinson’s disease (PD) and other diseases, what factors ar...

Descripción completa

Detalles Bibliográficos
Autores principales: Grauman, Åsa, Hansson, Mats, Nyholm, Dag, Jiltsova, Elena, Widner, Håkan, van Vliet, Trinette, Drevin, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773498/
https://www.ncbi.nlm.nih.gov/pubmed/36550460
http://dx.doi.org/10.1186/s12910-022-00878-6
_version_ 1784855204614635520
author Grauman, Åsa
Hansson, Mats
Nyholm, Dag
Jiltsova, Elena
Widner, Håkan
van Vliet, Trinette
Drevin, Jennifer
author_facet Grauman, Åsa
Hansson, Mats
Nyholm, Dag
Jiltsova, Elena
Widner, Håkan
van Vliet, Trinette
Drevin, Jennifer
author_sort Grauman, Åsa
collection PubMed
description BACKGROUND: The use of human embryonic stem cells (ES cells) for the development of medical therapies is surrounded with moral concerns. The aim of this study was to assess the public’s attitudes toward the use of ES cells for treatment of Parkinson’s disease (PD) and other diseases, what factors are most important to consider when using ES cells for drug development, and if there is an association between religious beliefs and attitudes toward using ES cells for medical treatment. METHODS: A randomly selected sample of the Swedish public, aged 18–87-years-old, completed an online survey (n = 467). The survey assessed socio-demographics, religious views, perceived moral status of the embryo, and attitudes toward using ES cells for medical treatment of PD and other diseases. Adjusted odds ratios (ORs) and 95% confidence intervals (CI) for positive vs. negative attitude toward using ES cells for drug development were computed using logistic regression. RESULTS: The respondents were positive about using ES for treatment; specifically, 70% totally agreed that it is acceptable to use ES cells for treatment of PD, while 40% totally agreed that it is acceptable to use ES cells for treatment but induced pluripotent cells is just as efficient. Religion being of little importance in one’s life was associated with a positive attitude toward using ES cells for treatment of PD (adjusted OR 6.39, 95% CI 2.78–14.71). The importance of being able “to access new, effective treatments against diseases that do not have any treatment available” was ranked as the most important factor to consider when using ES cells for drug development. CONCLUSION: Most respondents are positive about using ES cells for drug development, and making effective treatments accessible to those who do not have any. However, these attitudes are influenced by the specific disorder that the drug development is intended for, as well as the religious views and perceived moral status of the early embryo. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12910-022-00878-6.
format Online
Article
Text
id pubmed-9773498
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-97734982022-12-23 Attitudes and values among the Swedish general public to using human embryonic stem cells for medical treatment Grauman, Åsa Hansson, Mats Nyholm, Dag Jiltsova, Elena Widner, Håkan van Vliet, Trinette Drevin, Jennifer BMC Med Ethics Research BACKGROUND: The use of human embryonic stem cells (ES cells) for the development of medical therapies is surrounded with moral concerns. The aim of this study was to assess the public’s attitudes toward the use of ES cells for treatment of Parkinson’s disease (PD) and other diseases, what factors are most important to consider when using ES cells for drug development, and if there is an association between religious beliefs and attitudes toward using ES cells for medical treatment. METHODS: A randomly selected sample of the Swedish public, aged 18–87-years-old, completed an online survey (n = 467). The survey assessed socio-demographics, religious views, perceived moral status of the embryo, and attitudes toward using ES cells for medical treatment of PD and other diseases. Adjusted odds ratios (ORs) and 95% confidence intervals (CI) for positive vs. negative attitude toward using ES cells for drug development were computed using logistic regression. RESULTS: The respondents were positive about using ES for treatment; specifically, 70% totally agreed that it is acceptable to use ES cells for treatment of PD, while 40% totally agreed that it is acceptable to use ES cells for treatment but induced pluripotent cells is just as efficient. Religion being of little importance in one’s life was associated with a positive attitude toward using ES cells for treatment of PD (adjusted OR 6.39, 95% CI 2.78–14.71). The importance of being able “to access new, effective treatments against diseases that do not have any treatment available” was ranked as the most important factor to consider when using ES cells for drug development. CONCLUSION: Most respondents are positive about using ES cells for drug development, and making effective treatments accessible to those who do not have any. However, these attitudes are influenced by the specific disorder that the drug development is intended for, as well as the religious views and perceived moral status of the early embryo. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12910-022-00878-6. BioMed Central 2022-12-22 /pmc/articles/PMC9773498/ /pubmed/36550460 http://dx.doi.org/10.1186/s12910-022-00878-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Grauman, Åsa
Hansson, Mats
Nyholm, Dag
Jiltsova, Elena
Widner, Håkan
van Vliet, Trinette
Drevin, Jennifer
Attitudes and values among the Swedish general public to using human embryonic stem cells for medical treatment
title Attitudes and values among the Swedish general public to using human embryonic stem cells for medical treatment
title_full Attitudes and values among the Swedish general public to using human embryonic stem cells for medical treatment
title_fullStr Attitudes and values among the Swedish general public to using human embryonic stem cells for medical treatment
title_full_unstemmed Attitudes and values among the Swedish general public to using human embryonic stem cells for medical treatment
title_short Attitudes and values among the Swedish general public to using human embryonic stem cells for medical treatment
title_sort attitudes and values among the swedish general public to using human embryonic stem cells for medical treatment
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773498/
https://www.ncbi.nlm.nih.gov/pubmed/36550460
http://dx.doi.org/10.1186/s12910-022-00878-6
work_keys_str_mv AT graumanasa attitudesandvaluesamongtheswedishgeneralpublictousinghumanembryonicstemcellsformedicaltreatment
AT hanssonmats attitudesandvaluesamongtheswedishgeneralpublictousinghumanembryonicstemcellsformedicaltreatment
AT nyholmdag attitudesandvaluesamongtheswedishgeneralpublictousinghumanembryonicstemcellsformedicaltreatment
AT jiltsovaelena attitudesandvaluesamongtheswedishgeneralpublictousinghumanembryonicstemcellsformedicaltreatment
AT widnerhakan attitudesandvaluesamongtheswedishgeneralpublictousinghumanembryonicstemcellsformedicaltreatment
AT vanvliettrinette attitudesandvaluesamongtheswedishgeneralpublictousinghumanembryonicstemcellsformedicaltreatment
AT drevinjennifer attitudesandvaluesamongtheswedishgeneralpublictousinghumanembryonicstemcellsformedicaltreatment