Cargando…

Parallel single-cell and bulk transcriptome analyses reveal key features of the gastric tumor microenvironment

BACKGROUND: The tumor microenvironment (TME) has been shown to strongly influence treatment outcome for cancer patients in various indications and to influence the overall survival. However, the cells forming the TME in gastric cancer have not been extensively characterized. RESULTS: We combine bulk...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kang, Boxi, Camps, Jordi, Fan, Biao, Jiang, Hongpeng, Ibrahim, Mahmoud M., Hu, Xueda, Qin, Shishang, Kirchhoff, Dennis, Chiang, Derek Y., Wang, Shan, Ye, Yingjiang, Shen, Zhanlong, Bu, Zhaode, Zhang, Zemin, Roider, Helge G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773611/ https://www.ncbi.nlm.nih.gov/pubmed/36550535 http://dx.doi.org/10.1186/s13059-022-02828-2

Ejemplares similares

Cancer IgG, a potential prognostic marker, promotes colorectal cancer progression
por: Jiang, Hongpeng, et al.
Publicado: (2019)

Reshaping the tumour immune microenvironment in solid tumours via tumour cell and immune cell DNA methylation: from mechanisms to therapeutics
por: Zhong, Fengyun, et al.
Publicado: (2023)

Correction to: Reshaping the tumour immune microenvironment in solid tumours via tumour cell and immune cell DNA methylation: from mechanisms to therapeutics
por: Zhong, Fengyun, et al.
Publicado: (2023)

MicroRNA-4284 promotes gastric cancer tumorigenicity by targeting ten-eleven translocation 1
por: Li, Yansen, et al.
Publicado: (2018)

A commentary on: “A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells” – tumor microenvironment: the Achilles heel of cancer
por: Wei, Jingtao, et al.
Publicado: (2022)

IDH1 K224 acetylation promotes colorectal cancer via miR-9-5p/NHE1 axis-mediated regulation of acidic microenvironment
por: Wang, Bo, et al.
Publicado: (2023)

An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment
por: Yang, Bing, et al.
Publicado: (2022)

Histone deacetylase-mediated tumor microenvironment characteristics and synergistic immunotherapy in gastric cancer
por: Lin, Yilin, et al.
Publicado: (2023)

Understanding tumor ecosystems by single-cell sequencing: promises and limitations
por: Ren, Xianwen, et al.
Publicado: (2018)

A signature of 24 aging‑related gene pairs predict overall survival in gastric cancer
por: Zhang, Yankai, et al.
Publicado: (2021)

Porous silicon bulk acoustic wave resonator with integrated transducer
por: Aliev, Gazi N, et al.
Publicado: (2012)

Distinct epigenetic features of tumor-reactive CD8+ T cells in colorectal cancer patients revealed by genome-wide DNA methylation analysis
por: Yang, Rui, et al.
Publicado: (2019)

Young adults with colon cancer: clinical features and surgical outcomes
por: Wang, Chao, et al.
Publicado: (2023)

Biomarkers for immune checkpoint inhibitors in colorectal cancer: recent advances and future perspectives
por: Yang, Changjiang, et al.
Publicado: (2023)

Comments on Chinese guidelines for diagnosis and treatment of gastric cancer 2018 (English edition)
por: Bu, Zhaode, et al.
Publicado: (2020)

Pan-cancer tumor-infiltrating T cells: A great hallmark in cancer immunology research
por: Wang, Anqiang, et al.
Publicado: (2022)

Deep single-cell RNA sequencing data of individual T cells from treatment-naïve colorectal cancer patients
por: Zhang, Yuanyuan, et al.
Publicado: (2019)

GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis
por: Tang, Zefang, et al.
Publicado: (2019)

Parallel Aspects of the Microenvironment in Cancer and Autoimmune Disease
por: Rahat, Michal A., et al.
Publicado: (2016)

Cancer: a mirrored room between tumor bulk and tumor microenvironment
por: Hernández-Camarero, Pablo, et al.
Publicado: (2021)

ARHGAP11A Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric Cancer
por: Fan, Biao, et al.
Publicado: (2021)

Surgical treatment of gastric cancer: Current status and future directions
por: Chen, Jiahui, et al.
Publicado: (2021)

Meta-Analysis of Human Cancer Single-Cell RNA-Seq Datasets Using the IMMUcan Database
por: Camps, Jordi, et al.
Publicado: (2023)

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses
por: Tang, Zefang, et al.
Publicado: (2017)

Single-cell and bulk tissue sequencing unravels the heterogeneity of synovial microenvironment in arthrofibrosis
por: Chen, Xi, et al.
Publicado: (2023)

Clinical characteristics and genetic analysis of gene mutations in a Chinese pedigree with Peutz‐Jeghers syndrome
por: Qiu, Yudian, et al.
Publicado: (2019)

Lnc-HSD17B11-1:1 Functions as a Competing Endogenous RNA to Promote Colorectal Cancer Progression by Sponging miR-338-3p to Upregulate MACC1
por: Zhang, Wei, et al.
Publicado: (2020)

Prognostic value and immune infiltration of novel signatures in colon cancer microenvironment
por: Lin, Yilin, et al.
Publicado: (2021)

A novel long non-coding RNA lnc-GNAT1-1 is low expressed in colorectal cancer and acts as a tumor suppressor through regulating RKIP-NF-κB-Snail circuit
por: Ye, Chunxiang, et al.
Publicado: (2016)

Molecular Characterization and Clinical Relevance of RNA Binding Proteins in Colorectal Cancer
por: Zhang, Zhen, et al.
Publicado: (2020)

Landscape of cell heterogeneity and evolutionary trajectory in ulcerative colitis-associated colon cancer revealed by single-cell RNA sequencing
por: Wang, Quan, et al.
Publicado: (2021)

Characteristics of alpha-fetoprotein-positive gastric cancer revealed by analysis of cancer databases and transcriptome sequencing data
por: Li, Yansen, et al.
Publicado: (2023)

Phase II trial of prophylactic hyperthermic intraperitoneal chemotherapy in patients with locally advanced gastric cancer after curative surgery
por: Fan, Biao, et al.
Publicado: (2021)

How Signaling Molecules Regulate Tumor Microenvironment: Parallels to Wound Repair
por: Gál, Peter, et al.
Publicado: (2017)

Integrated single-cell and bulk characterization of cuproptosis key regulator PDHB and association with tumor microenvironment infiltration in clear cell renal cell carcinoma
por: Wu, Jiajin, et al.
Publicado: (2023)

Statistical Modeling of Transcription Factor Binding Affinities Predicts Regulatory Interactions
por: Manke, Thomas, et al.
Publicado: (2008)

SciBet as a portable and fast single cell type identifier
por: Li, Chenwei, et al.
Publicado: (2020)

Author Correction: SciBet as a portable and fast single cell type identifier
por: Li, Chenwei, et al.
Publicado: (2021)

The effect of ultrasound on bulk and surface nanobubbles: A review of the current status
por: Bu, Xiangning, et al.
Publicado: (2021)

Comparison of overall survival of gastric neoplasms containing neuroendocrine carcinoma components with gastric adenocarcinoma: a propensity score matching study
por: Chen, Jiahui, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_hp6a8t8ua9leb2cpbci1j5m1d6