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Mild blurry vision as the initial presentation of central nervous system relapses of acute lymphoblastic leukemia: a case report

BACKGROUND: Leukemia relapses after hematopoietic stem cell transplantation can sometimes occur from the central nervous system prior to relapse from the bone marrow, and manifestations varied. CASE REPORT: We present a case of mild blurry vision as the initial symptom of central nervous system rela...

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Autores principales: Zhang, Yuehong, Zhang, Zhimeng, Mo, Wenjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773614/
https://www.ncbi.nlm.nih.gov/pubmed/36550447
http://dx.doi.org/10.1186/s12886-022-02697-0
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author Zhang, Yuehong
Zhang, Zhimeng
Mo, Wenjian
author_facet Zhang, Yuehong
Zhang, Zhimeng
Mo, Wenjian
author_sort Zhang, Yuehong
collection PubMed
description BACKGROUND: Leukemia relapses after hematopoietic stem cell transplantation can sometimes occur from the central nervous system prior to relapse from the bone marrow, and manifestations varied. CASE REPORT: We present a case of mild blurry vision as the initial symptom of central nervous system relapse of adult acute lymphoblastic leukemia. A 30-year-old man presented with a 1 week history of painless visual loss in both eyes. At that time there were no headaches or other systemic features. The neurological examination was without positive findings except bilateral optic nerve edema. He had a history of acute lymphoblastic leukemia and hematopoietic stem cell transplantation, which had been in clinical remission post-transplant for 1 year. Lumbar puncture revealed relapsed disease within the central nervous system, confirmed with cerebrospinal fluid leukemic blasts. CONCLUSIONS: It highlights the need for ophthalmologists to be aware of the possibility of central nervous system involvement in patients with the setting of leukemia when visual symptoms as the initial manifestation.
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spelling pubmed-97736142022-12-23 Mild blurry vision as the initial presentation of central nervous system relapses of acute lymphoblastic leukemia: a case report Zhang, Yuehong Zhang, Zhimeng Mo, Wenjian BMC Ophthalmol Case Report BACKGROUND: Leukemia relapses after hematopoietic stem cell transplantation can sometimes occur from the central nervous system prior to relapse from the bone marrow, and manifestations varied. CASE REPORT: We present a case of mild blurry vision as the initial symptom of central nervous system relapse of adult acute lymphoblastic leukemia. A 30-year-old man presented with a 1 week history of painless visual loss in both eyes. At that time there were no headaches or other systemic features. The neurological examination was without positive findings except bilateral optic nerve edema. He had a history of acute lymphoblastic leukemia and hematopoietic stem cell transplantation, which had been in clinical remission post-transplant for 1 year. Lumbar puncture revealed relapsed disease within the central nervous system, confirmed with cerebrospinal fluid leukemic blasts. CONCLUSIONS: It highlights the need for ophthalmologists to be aware of the possibility of central nervous system involvement in patients with the setting of leukemia when visual symptoms as the initial manifestation. BioMed Central 2022-12-22 /pmc/articles/PMC9773614/ /pubmed/36550447 http://dx.doi.org/10.1186/s12886-022-02697-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Zhang, Yuehong
Zhang, Zhimeng
Mo, Wenjian
Mild blurry vision as the initial presentation of central nervous system relapses of acute lymphoblastic leukemia: a case report
title Mild blurry vision as the initial presentation of central nervous system relapses of acute lymphoblastic leukemia: a case report
title_full Mild blurry vision as the initial presentation of central nervous system relapses of acute lymphoblastic leukemia: a case report
title_fullStr Mild blurry vision as the initial presentation of central nervous system relapses of acute lymphoblastic leukemia: a case report
title_full_unstemmed Mild blurry vision as the initial presentation of central nervous system relapses of acute lymphoblastic leukemia: a case report
title_short Mild blurry vision as the initial presentation of central nervous system relapses of acute lymphoblastic leukemia: a case report
title_sort mild blurry vision as the initial presentation of central nervous system relapses of acute lymphoblastic leukemia: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773614/
https://www.ncbi.nlm.nih.gov/pubmed/36550447
http://dx.doi.org/10.1186/s12886-022-02697-0
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