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Mild blurry vision as the initial presentation of central nervous system relapses of acute lymphoblastic leukemia: a case report
BACKGROUND: Leukemia relapses after hematopoietic stem cell transplantation can sometimes occur from the central nervous system prior to relapse from the bone marrow, and manifestations varied. CASE REPORT: We present a case of mild blurry vision as the initial symptom of central nervous system rela...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773614/ https://www.ncbi.nlm.nih.gov/pubmed/36550447 http://dx.doi.org/10.1186/s12886-022-02697-0 |
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author | Zhang, Yuehong Zhang, Zhimeng Mo, Wenjian |
author_facet | Zhang, Yuehong Zhang, Zhimeng Mo, Wenjian |
author_sort | Zhang, Yuehong |
collection | PubMed |
description | BACKGROUND: Leukemia relapses after hematopoietic stem cell transplantation can sometimes occur from the central nervous system prior to relapse from the bone marrow, and manifestations varied. CASE REPORT: We present a case of mild blurry vision as the initial symptom of central nervous system relapse of adult acute lymphoblastic leukemia. A 30-year-old man presented with a 1 week history of painless visual loss in both eyes. At that time there were no headaches or other systemic features. The neurological examination was without positive findings except bilateral optic nerve edema. He had a history of acute lymphoblastic leukemia and hematopoietic stem cell transplantation, which had been in clinical remission post-transplant for 1 year. Lumbar puncture revealed relapsed disease within the central nervous system, confirmed with cerebrospinal fluid leukemic blasts. CONCLUSIONS: It highlights the need for ophthalmologists to be aware of the possibility of central nervous system involvement in patients with the setting of leukemia when visual symptoms as the initial manifestation. |
format | Online Article Text |
id | pubmed-9773614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-97736142022-12-23 Mild blurry vision as the initial presentation of central nervous system relapses of acute lymphoblastic leukemia: a case report Zhang, Yuehong Zhang, Zhimeng Mo, Wenjian BMC Ophthalmol Case Report BACKGROUND: Leukemia relapses after hematopoietic stem cell transplantation can sometimes occur from the central nervous system prior to relapse from the bone marrow, and manifestations varied. CASE REPORT: We present a case of mild blurry vision as the initial symptom of central nervous system relapse of adult acute lymphoblastic leukemia. A 30-year-old man presented with a 1 week history of painless visual loss in both eyes. At that time there were no headaches or other systemic features. The neurological examination was without positive findings except bilateral optic nerve edema. He had a history of acute lymphoblastic leukemia and hematopoietic stem cell transplantation, which had been in clinical remission post-transplant for 1 year. Lumbar puncture revealed relapsed disease within the central nervous system, confirmed with cerebrospinal fluid leukemic blasts. CONCLUSIONS: It highlights the need for ophthalmologists to be aware of the possibility of central nervous system involvement in patients with the setting of leukemia when visual symptoms as the initial manifestation. BioMed Central 2022-12-22 /pmc/articles/PMC9773614/ /pubmed/36550447 http://dx.doi.org/10.1186/s12886-022-02697-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Zhang, Yuehong Zhang, Zhimeng Mo, Wenjian Mild blurry vision as the initial presentation of central nervous system relapses of acute lymphoblastic leukemia: a case report |
title | Mild blurry vision as the initial presentation of central nervous system relapses of acute lymphoblastic leukemia: a case report |
title_full | Mild blurry vision as the initial presentation of central nervous system relapses of acute lymphoblastic leukemia: a case report |
title_fullStr | Mild blurry vision as the initial presentation of central nervous system relapses of acute lymphoblastic leukemia: a case report |
title_full_unstemmed | Mild blurry vision as the initial presentation of central nervous system relapses of acute lymphoblastic leukemia: a case report |
title_short | Mild blurry vision as the initial presentation of central nervous system relapses of acute lymphoblastic leukemia: a case report |
title_sort | mild blurry vision as the initial presentation of central nervous system relapses of acute lymphoblastic leukemia: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773614/ https://www.ncbi.nlm.nih.gov/pubmed/36550447 http://dx.doi.org/10.1186/s12886-022-02697-0 |
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