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Kill or corrupt: Mechanisms of action and drug-resistance of nucleotide analogues against SARS-CoV-2
Nucleoside/tide analogues (NAs) have long been used in the fight against viral diseases, and now present a promising option for the treatment of COVID-19. Once activated to the 5′-triphosphate state, NAs act by targeting the viral RNA-dependent RNA-polymerase for incorporation into the viral RNA gen...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier B.V.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773703/ https://www.ncbi.nlm.nih.gov/pubmed/36567022 http://dx.doi.org/10.1016/j.antiviral.2022.105501 |