Cargando…

Dupilumab improves clinical symptoms in children with Netherton syndrome by suppressing Th2-mediated inflammation

BACKGROUND: Netherton syndrome is a rare, life-threatening autosomal recessive genetic disorder with no effective treatment yet. Skin barrier dysfunction caused by SPINK5 gene mutations is a hallmark of the disease. Antigen penetration through the defective skin and nonspecific inflammation provide...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Shi, Wu, Xuege, Jiang, Jinqiu, Yu, Shijuan, Fang, Xiao, Yang, Huan, Bai, Xiaoming, Wang, Hua, Luo, Xiaoyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773867/ https://www.ncbi.nlm.nih.gov/pubmed/36569942 http://dx.doi.org/10.3389/fimmu.2022.1054422

Ejemplares similares

Dupilumab Improves Pruritus in Netherton Syndrome: A Case Study
por: Inaba, Yutaka, et al.
Publicado: (2022)

Report of two sisters with Netherton syndrome successfully treated with dupilumab and review of the literature
por: Martin-García, Cristina, et al.
Publicado: (2023)

Treatment Experiences with Intravenous Immunoglobulins, Ixekizumab, Dupilumab, and Anakinra in Netherton Syndrome: A Case Series
por: Ragamin, Aviël, et al.
Publicado: (2023)

Dupilumab improve acquired reactive perforating collagenosis characterized by type 2 inflammation
por: Liu, Ben, et al.
Publicado: (2023)

Outcomes of Systemic Treatment in Children and Adults With Netherton Syndrome: A Systematic Review
por: Nouwen, Anouk E. M., et al.
Publicado: (2022)

Crosstalk Between Circulating Follicular T Helper Cells and Regulatory B Cells in Children With Extrinsic Atopic Dermatitis
por: Jiang, Jinqiu, et al.
Publicado: (2021)

Bamboo Hair in Netherton's Syndrome
por: Salodkar, Atul D, et al.
Publicado: (2009)

Netherton Syndrome with Pili Torti
por: Srinivas, Sahana M, et al.
Publicado: (2013)

Poster 1023: Dupilumab suppresses Th2 inflammation in adult asthma and atopic dermatitis
por: Swanson, Brian, et al.
Publicado: (2014)

High loading-dose of dupilumab resulted in rapid disease control in pediatric patients with atopic dermatitis
por: Wang, Ao, et al.
Publicado: (2023)

Netherton syndrome: A rare genodermatosis
por: Dey, Vivek Kumar
Publicado: (2011)

A Case Report on Netherton Syndrome
por: Abdalrheem, Wiel O, et al.
Publicado: (2020)

Successful use of secukinumab in Netherton syndrome
por: Blanchard, Sarah K., et al.
Publicado: (2020)

Biological treatments for pediatric Netherton syndrome
por: Pontone, Matteo, et al.
Publicado: (2022)

Severe Hypernatremia as Presentation of Netherton Syndrome
por: Di Nora, A., et al.
Publicado: (2023)

Trichorrhexis invaginata and ichthyosiform erythroderma in netherton syndrome
por: Ahmadian Heris, Javad, et al.
Publicado: (2021)

Skin Microbiota and Clinical Associations in Netherton Syndrome
por: Sillanpää, Veera, et al.
Publicado: (2021)

Netherton Syndrome in Children: Management and Future Perspectives
por: Barbati, Federica, et al.
Publicado: (2021)

Dupilumab effectively and rapidly treats bullous pemphigoid by inhibiting the activities of multiple cell types
por: Yan, Tianmeng, et al.
Publicado: (2023)

Efficacy and Safety of Dupilumab in Moderate-to-Severe Bullous Pemphigoid
por: Zhang, Yihua, et al.
Publicado: (2021)

Dupilumab for the treatment of prurigo nodularis: A systematic review
por: Cao, Peng, et al.
Publicado: (2023)

Genetic activation of Nrf2 reduces cutaneous symptoms in a murine model of Netherton syndrome
por: Muzumdar, Sukalp, et al.
Publicado: (2020)

Netherton Syndrome, a Case Report and Review of Literature
por: Boskabadi, Hassan, et al.
Publicado: (2013)

Infliximab therapy for Netherton syndrome: A case report
por: Roda, Ângela, et al.
Publicado: (2017)

Immune cell phenotype and functional defects in Netherton syndrome
por: Eränkö, Elina, et al.
Publicado: (2018)

Netherton Syndrome: A Case Report and Review of Literature
por: Saleem, Hafiz M. Kashif, et al.
Publicado: (2018)

Oral Tofacitinib Therapy for the Effective Management of Netherton Syndrome
por: Dodeja, Ajay, et al.
Publicado: (2023)

Commentary: Efficacy and Safety of Dupilumab in Moderate-to-Severe Bullous Pemphigoid
por: Wang, Si-Hang, et al.
Publicado: (2021)

Case Report: Combination of Omalizumab and Dupilumab for Recalcitrant Bullous Pemphigoid
por: Seyed Jafari, S. Morteza, et al.
Publicado: (2021)

Integrated metabolomics and lipidomics study of patients with atopic dermatitis in response to dupilumab
por: Zhang, Lishan, et al.
Publicado: (2022)

Trichoscopy as a diagnostic tool in trichorrhexis invaginata and Netherton syndrome()
por: Bittencourt, Maraya de Jesus Semblano, et al.
Publicado: (2015)

KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome
por: Furio, Laetitia, et al.
Publicado: (2015)

An 8-Year-Old Child with Delayed Diagnosis of Netherton Syndrome
por: Leung, Alexander K. C., et al.
Publicado: (2018)

Blocking Th2 Signaling Pathway Alleviates the Clinical Symptoms and Inflammation in Allergic Conjunctivitis
por: Tao, Zhiyan, et al.
Publicado: (2023)

Rituximab, Omalizumab, and Dupilumab Treatment Outcomes in Bullous Pemphigoid: A Systematic Review
por: Cao, Peng, et al.
Publicado: (2022)

P2Y1R Ligation Suppresses Th17 Cell Differentiation and Alleviates Colonic Inflammation in an AMPK-Dependent Manner
por: Chang, Yao-Yao, et al.
Publicado: (2022)

Phage Therapy in a 16-Year-Old Boy with Netherton Syndrome
por: Zhvania, Pikria, et al.
Publicado: (2017)

Netherton syndrome; neuropsychological and psychosocial functioning of child and adult patients and their parents
por: Versteegh, Josette JWM, et al.
Publicado: (2018)

Netherton's Syndrome: A Case of Two Male Siblings Diagnosed in Adulthood
por: Flora, Akshay, et al.
Publicado: (2020)

Tape-Strip Proteomic Profiling of Atopic Dermatitis on Dupilumab Identifies Minimally Invasive Biomarkers
por: He, Helen, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ebjiqjha1kin1e1puuh953oar7