Mechanistic Study of Diketopiperazine Formation during Solid-Phase Peptide Synthesis of Tirzepatide

[Image: see text] This study focused on investigating diketopiperazine (DKP) and the formation of associated double-amino-acid deletion impurities during linear solid-phase peptide synthesis (SPPS) of tirzepatide (TZP). We identified that the DKP formation primarily occurred during the Fmoc-deprotec...

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Detalles Bibliográficos
Autores principales: Wang, Jingyao, Berglund, Mark R., Braden, Timothy, Embry, Matthew C., Johnson, Martin D., Groskreutz, Stephen R., Sayyed, Fareed Bhasha, Tsukanov, Sergey Vladimirovich, White, Timothy D., Jalan, Ankur, Seibert, Kevin D., Kopach, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773959/
https://www.ncbi.nlm.nih.gov/pubmed/36570276
http://dx.doi.org/10.1021/acsomega.2c05915

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