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The Antimicrobial Resistance (AMR) Rates of Uropathogens in a Rural Western African Area—A Retrospective Single-Center Study from Kpando, Ghana

Little is known about the antimicrobial resistance (AMR) status of uropathogens in Western Africa. We performed a retrospective evaluation of urine cultures collected from the rural Margret Marquart Catholic Hospital, Kpando, Ghana during the time period from October 2019–December 2021. Urine sample...

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Autores principales: Deininger, Susanne, Gründler, Therese, Deininger, Sebastian Hubertus Markus, Lütcke, Karina, Lütcke, Harry, Agbesi, James, Ladzaka, Williams, Gyamfi, Eric, Wichlas, Florian, Hofmann, Valeska, Erne, Eva, Törzsök, Peter, Lusuardi, Lukas, Kern, Jan Marco, Deininger, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774093/
https://www.ncbi.nlm.nih.gov/pubmed/36551465
http://dx.doi.org/10.3390/antibiotics11121808
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author Deininger, Susanne
Gründler, Therese
Deininger, Sebastian Hubertus Markus
Lütcke, Karina
Lütcke, Harry
Agbesi, James
Ladzaka, Williams
Gyamfi, Eric
Wichlas, Florian
Hofmann, Valeska
Erne, Eva
Törzsök, Peter
Lusuardi, Lukas
Kern, Jan Marco
Deininger, Christian
author_facet Deininger, Susanne
Gründler, Therese
Deininger, Sebastian Hubertus Markus
Lütcke, Karina
Lütcke, Harry
Agbesi, James
Ladzaka, Williams
Gyamfi, Eric
Wichlas, Florian
Hofmann, Valeska
Erne, Eva
Törzsök, Peter
Lusuardi, Lukas
Kern, Jan Marco
Deininger, Christian
author_sort Deininger, Susanne
collection PubMed
description Little is known about the antimicrobial resistance (AMR) status of uropathogens in Western Africa. We performed a retrospective evaluation of urine cultures collected from the rural Margret Marquart Catholic Hospital, Kpando, Ghana during the time period from October 2019–December 2021. Urine samples from 348 patients (median age 40 years, 52.6% male) were examined. Of these, 125 (35.9%) showed either fungal or bacterial growth, including Escherichia coli in 48 (38.4%), Candida species (spp.) in 29 (23.2%), Klebsiella spp. in 27 (21.6%), Proteus spp. in 12 (9.6%), Citrobacter spp. in 10 (8.0%), Salmonella spp. in 4 (3.2%), Staphylococcus spp. in 3 (2.4%), and Pseudomonas spp. in 2 (1.6%) cases. Two bacterial spp. were detected in 7 samples (5.6%). Antibiotic susceptibility testing showed resistance to a mean 8.6 out of 11 tested antibiotics per patient. Significant predictors (p < 0.05) of bacterial growth were age (OR 1.03), female sex (OR 3.84), and the number of pus cells (OR 1.05) and epithelial cells (OR 1.07) in urine microscopy. We observed an alarmingly high AMR rate among the uropathogens detected, even to reserve antibiotics. A similar resistance profile can be expected in West African patients living in high-income countries. These observations warrant the implementation of restrictive antibiotic protocols, together with the expansion of urine culture testing capacities, improvement of documentation and reporting of AMR rates, and continued research and development of new antibiotic therapies in order to stem the progression of AMR in this West African region.
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spelling pubmed-97740932022-12-23 The Antimicrobial Resistance (AMR) Rates of Uropathogens in a Rural Western African Area—A Retrospective Single-Center Study from Kpando, Ghana Deininger, Susanne Gründler, Therese Deininger, Sebastian Hubertus Markus Lütcke, Karina Lütcke, Harry Agbesi, James Ladzaka, Williams Gyamfi, Eric Wichlas, Florian Hofmann, Valeska Erne, Eva Törzsök, Peter Lusuardi, Lukas Kern, Jan Marco Deininger, Christian Antibiotics (Basel) Article Little is known about the antimicrobial resistance (AMR) status of uropathogens in Western Africa. We performed a retrospective evaluation of urine cultures collected from the rural Margret Marquart Catholic Hospital, Kpando, Ghana during the time period from October 2019–December 2021. Urine samples from 348 patients (median age 40 years, 52.6% male) were examined. Of these, 125 (35.9%) showed either fungal or bacterial growth, including Escherichia coli in 48 (38.4%), Candida species (spp.) in 29 (23.2%), Klebsiella spp. in 27 (21.6%), Proteus spp. in 12 (9.6%), Citrobacter spp. in 10 (8.0%), Salmonella spp. in 4 (3.2%), Staphylococcus spp. in 3 (2.4%), and Pseudomonas spp. in 2 (1.6%) cases. Two bacterial spp. were detected in 7 samples (5.6%). Antibiotic susceptibility testing showed resistance to a mean 8.6 out of 11 tested antibiotics per patient. Significant predictors (p < 0.05) of bacterial growth were age (OR 1.03), female sex (OR 3.84), and the number of pus cells (OR 1.05) and epithelial cells (OR 1.07) in urine microscopy. We observed an alarmingly high AMR rate among the uropathogens detected, even to reserve antibiotics. A similar resistance profile can be expected in West African patients living in high-income countries. These observations warrant the implementation of restrictive antibiotic protocols, together with the expansion of urine culture testing capacities, improvement of documentation and reporting of AMR rates, and continued research and development of new antibiotic therapies in order to stem the progression of AMR in this West African region. MDPI 2022-12-13 /pmc/articles/PMC9774093/ /pubmed/36551465 http://dx.doi.org/10.3390/antibiotics11121808 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Deininger, Susanne
Gründler, Therese
Deininger, Sebastian Hubertus Markus
Lütcke, Karina
Lütcke, Harry
Agbesi, James
Ladzaka, Williams
Gyamfi, Eric
Wichlas, Florian
Hofmann, Valeska
Erne, Eva
Törzsök, Peter
Lusuardi, Lukas
Kern, Jan Marco
Deininger, Christian
The Antimicrobial Resistance (AMR) Rates of Uropathogens in a Rural Western African Area—A Retrospective Single-Center Study from Kpando, Ghana
title The Antimicrobial Resistance (AMR) Rates of Uropathogens in a Rural Western African Area—A Retrospective Single-Center Study from Kpando, Ghana
title_full The Antimicrobial Resistance (AMR) Rates of Uropathogens in a Rural Western African Area—A Retrospective Single-Center Study from Kpando, Ghana
title_fullStr The Antimicrobial Resistance (AMR) Rates of Uropathogens in a Rural Western African Area—A Retrospective Single-Center Study from Kpando, Ghana
title_full_unstemmed The Antimicrobial Resistance (AMR) Rates of Uropathogens in a Rural Western African Area—A Retrospective Single-Center Study from Kpando, Ghana
title_short The Antimicrobial Resistance (AMR) Rates of Uropathogens in a Rural Western African Area—A Retrospective Single-Center Study from Kpando, Ghana
title_sort antimicrobial resistance (amr) rates of uropathogens in a rural western african area—a retrospective single-center study from kpando, ghana
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774093/
https://www.ncbi.nlm.nih.gov/pubmed/36551465
http://dx.doi.org/10.3390/antibiotics11121808
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