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About 3D Printability of Thermoplastic Collagen for Biomedical Applications

With more than 1.5 million total knee and hip implants placed each year, there is an urgent need for a drug delivery system that can effectively support the repair of bone infections. Scaffolds made of natural biopolymers are widely used for this purpose due to their biocompatibility, biodegradabili...

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Autores principales: Passos, Marina, Zankovic, Sergej, Minas, Graça, Klüver, Enno, Baltzer, Marit, Schmal, Hagen, Seidenstuecker, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774095/
https://www.ncbi.nlm.nih.gov/pubmed/36550986
http://dx.doi.org/10.3390/bioengineering9120780
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author Passos, Marina
Zankovic, Sergej
Minas, Graça
Klüver, Enno
Baltzer, Marit
Schmal, Hagen
Seidenstuecker, Michael
author_facet Passos, Marina
Zankovic, Sergej
Minas, Graça
Klüver, Enno
Baltzer, Marit
Schmal, Hagen
Seidenstuecker, Michael
author_sort Passos, Marina
collection PubMed
description With more than 1.5 million total knee and hip implants placed each year, there is an urgent need for a drug delivery system that can effectively support the repair of bone infections. Scaffolds made of natural biopolymers are widely used for this purpose due to their biocompatibility, biodegradability, and suitable mechanical properties. However, the poor processability is a bottleneck, as highly customizable scaffolds are desired. The aim of the present research is to develop a scaffold made of thermoplastic collagen (TC) using 3D printing technology. The viscosity of the material was measured using a rheometer. A 3D bioplotter was used to fabricate the scaffolds out of TC. The mechanical properties of the TC scaffolds were performed using tension/compression testing on a Zwick/Roell universal testing machine. TC shows better compressibility with increasing temperature and a decrease in dynamic viscosity (η), storage modulus (G′), and loss modulus (G″). The compressive strength of the TC scaffolds was between 3–10 MPa, depending on the geometry (cylinder or cuboid, with different infills). We have demonstrated for the first time that TC can be used to fabricate porous scaffolds by 3D printing in various geometries.
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spelling pubmed-97740952022-12-23 About 3D Printability of Thermoplastic Collagen for Biomedical Applications Passos, Marina Zankovic, Sergej Minas, Graça Klüver, Enno Baltzer, Marit Schmal, Hagen Seidenstuecker, Michael Bioengineering (Basel) Article With more than 1.5 million total knee and hip implants placed each year, there is an urgent need for a drug delivery system that can effectively support the repair of bone infections. Scaffolds made of natural biopolymers are widely used for this purpose due to their biocompatibility, biodegradability, and suitable mechanical properties. However, the poor processability is a bottleneck, as highly customizable scaffolds are desired. The aim of the present research is to develop a scaffold made of thermoplastic collagen (TC) using 3D printing technology. The viscosity of the material was measured using a rheometer. A 3D bioplotter was used to fabricate the scaffolds out of TC. The mechanical properties of the TC scaffolds were performed using tension/compression testing on a Zwick/Roell universal testing machine. TC shows better compressibility with increasing temperature and a decrease in dynamic viscosity (η), storage modulus (G′), and loss modulus (G″). The compressive strength of the TC scaffolds was between 3–10 MPa, depending on the geometry (cylinder or cuboid, with different infills). We have demonstrated for the first time that TC can be used to fabricate porous scaffolds by 3D printing in various geometries. MDPI 2022-12-07 /pmc/articles/PMC9774095/ /pubmed/36550986 http://dx.doi.org/10.3390/bioengineering9120780 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Passos, Marina
Zankovic, Sergej
Minas, Graça
Klüver, Enno
Baltzer, Marit
Schmal, Hagen
Seidenstuecker, Michael
About 3D Printability of Thermoplastic Collagen for Biomedical Applications
title About 3D Printability of Thermoplastic Collagen for Biomedical Applications
title_full About 3D Printability of Thermoplastic Collagen for Biomedical Applications
title_fullStr About 3D Printability of Thermoplastic Collagen for Biomedical Applications
title_full_unstemmed About 3D Printability of Thermoplastic Collagen for Biomedical Applications
title_short About 3D Printability of Thermoplastic Collagen for Biomedical Applications
title_sort about 3d printability of thermoplastic collagen for biomedical applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774095/
https://www.ncbi.nlm.nih.gov/pubmed/36550986
http://dx.doi.org/10.3390/bioengineering9120780
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