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Resveratrol: Its Path from Isolation to Therapeutic Action in Eye Diseases

Due to the confirmed therapeutic potential of resveratrol (Rv) for eye diseases, namely its powerful anti-angiogenic and antioxidant effects, this molecule must be studied more deeply. Nowadays, the pharmaceutic and pharmacokinetic available studies offer a troubling picture because of its low stabi...

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Detalles Bibliográficos
Autores principales: Pop, Roxana, Daescu, Adela, Rugina, Dumitrita, Pintea, Adela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774148/
https://www.ncbi.nlm.nih.gov/pubmed/36552655
http://dx.doi.org/10.3390/antiox11122447
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author Pop, Roxana
Daescu, Adela
Rugina, Dumitrita
Pintea, Adela
author_facet Pop, Roxana
Daescu, Adela
Rugina, Dumitrita
Pintea, Adela
author_sort Pop, Roxana
collection PubMed
description Due to the confirmed therapeutic potential of resveratrol (Rv) for eye diseases, namely its powerful anti-angiogenic and antioxidant effects, this molecule must be studied more deeply. Nowadays, the pharmaceutic and pharmacokinetic available studies offer a troubling picture because of its low stability and bioavailability. To overcome this problem, researchers started to design and create different delivery systems that could improve the delivery amount of Rv. Therefore, this review aims to shed light on the proper and efficient techniques to isolate, purify and quantify the Rv molecule, and how this therapeutic molecule can be a part of a delivery system. The Rv great impact on aspects regarding its stability, bioavailability and absorption are also debated here, based on the existent literature on in vitro and in vivo human and animal studies. Moreover, after its absorption the Rv influence at the molecular level in ocular pathologies is described. In addition, the present review summarizes the available literature about Rv, hoping that Rv will gain more attention to investigate its unexplored side.
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spelling pubmed-97741482022-12-23 Resveratrol: Its Path from Isolation to Therapeutic Action in Eye Diseases Pop, Roxana Daescu, Adela Rugina, Dumitrita Pintea, Adela Antioxidants (Basel) Review Due to the confirmed therapeutic potential of resveratrol (Rv) for eye diseases, namely its powerful anti-angiogenic and antioxidant effects, this molecule must be studied more deeply. Nowadays, the pharmaceutic and pharmacokinetic available studies offer a troubling picture because of its low stability and bioavailability. To overcome this problem, researchers started to design and create different delivery systems that could improve the delivery amount of Rv. Therefore, this review aims to shed light on the proper and efficient techniques to isolate, purify and quantify the Rv molecule, and how this therapeutic molecule can be a part of a delivery system. The Rv great impact on aspects regarding its stability, bioavailability and absorption are also debated here, based on the existent literature on in vitro and in vivo human and animal studies. Moreover, after its absorption the Rv influence at the molecular level in ocular pathologies is described. In addition, the present review summarizes the available literature about Rv, hoping that Rv will gain more attention to investigate its unexplored side. MDPI 2022-12-12 /pmc/articles/PMC9774148/ /pubmed/36552655 http://dx.doi.org/10.3390/antiox11122447 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pop, Roxana
Daescu, Adela
Rugina, Dumitrita
Pintea, Adela
Resveratrol: Its Path from Isolation to Therapeutic Action in Eye Diseases
title Resveratrol: Its Path from Isolation to Therapeutic Action in Eye Diseases
title_full Resveratrol: Its Path from Isolation to Therapeutic Action in Eye Diseases
title_fullStr Resveratrol: Its Path from Isolation to Therapeutic Action in Eye Diseases
title_full_unstemmed Resveratrol: Its Path from Isolation to Therapeutic Action in Eye Diseases
title_short Resveratrol: Its Path from Isolation to Therapeutic Action in Eye Diseases
title_sort resveratrol: its path from isolation to therapeutic action in eye diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774148/
https://www.ncbi.nlm.nih.gov/pubmed/36552655
http://dx.doi.org/10.3390/antiox11122447
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