Fortuitous Somatic Mutations during Antibody Evolution Endow Broad Neutralization against SARS-CoV-2 Omicron Variants

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Striking antibody evasion by emerging circulating SARS-CoV-2 variants drives the identification of broadly neutralizing antibodies (bNAbs). However, how a bNAb acquires increased neutralization breadth during antibody evolution is still elusive. Here, we identified a clonally-related antibody family...

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Detalles Bibliográficos
Autores principales: Wu, Jianbo, Chen, Zhenguo, Gao, Yidan, Wang, Zegen, Wang, Jiarong, Chiang, Bing-Yu, Zhou, Yunjiao, Han, Yuru, Zhan, Wuqiang, Xie, Minxiang, Jiang, Weiyu, Zhang, Xiang, Hao, Aihua, Xia, Anqi, He, Jiaying, Xue, Song, Mayer, Christian T., Wu, Fan, Wang, Bin, Zhang, Lunan, Sun, Lei, Wang, Qiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774204/
https://www.ncbi.nlm.nih.gov/pubmed/36561175
http://dx.doi.org/10.1101/2022.12.12.520172

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