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Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy

An 8-year-old girl diagnosed with cardiofaciocutaneous syndrome presented to our department with gingival pain, inflammation, and bleeding. Her medical history included hypoplasia of the corpus callosum, intellectual disability, trichothiodystrophy, global developmental delay, myopia, laryngomalacia...

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Autores principales: Muñoz Navarro, Carolina, del Carmen Sánchez Beltrán, María, Arriagada Vargas, Carolina, Batalla Vázquez, Pilar, Diniz Freitas, Márcio, Limeres Posse, Jacobo, Diz Dios, Pedro, García Mato, Eliane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774349/
https://www.ncbi.nlm.nih.gov/pubmed/36551411
http://dx.doi.org/10.3390/antibiotics11121754
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author Muñoz Navarro, Carolina
del Carmen Sánchez Beltrán, María
Arriagada Vargas, Carolina
Batalla Vázquez, Pilar
Diniz Freitas, Márcio
Limeres Posse, Jacobo
Diz Dios, Pedro
García Mato, Eliane
author_facet Muñoz Navarro, Carolina
del Carmen Sánchez Beltrán, María
Arriagada Vargas, Carolina
Batalla Vázquez, Pilar
Diniz Freitas, Márcio
Limeres Posse, Jacobo
Diz Dios, Pedro
García Mato, Eliane
author_sort Muñoz Navarro, Carolina
collection PubMed
description An 8-year-old girl diagnosed with cardiofaciocutaneous syndrome presented to our department with gingival pain, inflammation, and bleeding. Her medical history included hypoplasia of the corpus callosum, intellectual disability, trichothiodystrophy, global developmental delay, myopia, laryngomalacia, hypothyroidism, and osteoporosis. A diagnosis was reached of “periodontitis as a direct manifestation of systemic diseases”. During 9 years of follow-up, there were exacerbation episodes with spontaneous gum bleeding, ulcers in the interdental papilla, tooth mobility, and progressive tooth loss. Some of these exacerbation episodes resolved clinically with the administration of amoxicillin and metronidazole. We therefore proposed an oral microbiome study (subgingival and saliva samples) before and after antibiotic therapy. The most abundant genera at the subgingival level before administering antibiotics were Prevotella, Streptococcus, Fusobacterium, Leptotrichia, and Aggregatibacter. Of the 94 genera sequenced, 57 were less abundant in the post-treatment state than at baseline, particularly certain Gram-negative periodontal pathogens such as Porphyromonas, Treponema, Aggregatibacter, Fusobacterium, and Campylobacter. In contrast, other genera related to oral health, such as Haemophilus, Granulicatella, and Abiotrophia, showed an increase after administering the antibiotic. In conclusion, periodontitis exacerbations as a direct manifestation of systemic disease can occasionally be controlled exclusively with systemic antibiotics, without the need for performing mechanical periodontal therapy. This clinical recovery is correlated to substantial changes in the oral microbiome, which lead to the recovery of eubiosis of the microbiota.
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spelling pubmed-97743492022-12-23 Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy Muñoz Navarro, Carolina del Carmen Sánchez Beltrán, María Arriagada Vargas, Carolina Batalla Vázquez, Pilar Diniz Freitas, Márcio Limeres Posse, Jacobo Diz Dios, Pedro García Mato, Eliane Antibiotics (Basel) Case Report An 8-year-old girl diagnosed with cardiofaciocutaneous syndrome presented to our department with gingival pain, inflammation, and bleeding. Her medical history included hypoplasia of the corpus callosum, intellectual disability, trichothiodystrophy, global developmental delay, myopia, laryngomalacia, hypothyroidism, and osteoporosis. A diagnosis was reached of “periodontitis as a direct manifestation of systemic diseases”. During 9 years of follow-up, there were exacerbation episodes with spontaneous gum bleeding, ulcers in the interdental papilla, tooth mobility, and progressive tooth loss. Some of these exacerbation episodes resolved clinically with the administration of amoxicillin and metronidazole. We therefore proposed an oral microbiome study (subgingival and saliva samples) before and after antibiotic therapy. The most abundant genera at the subgingival level before administering antibiotics were Prevotella, Streptococcus, Fusobacterium, Leptotrichia, and Aggregatibacter. Of the 94 genera sequenced, 57 were less abundant in the post-treatment state than at baseline, particularly certain Gram-negative periodontal pathogens such as Porphyromonas, Treponema, Aggregatibacter, Fusobacterium, and Campylobacter. In contrast, other genera related to oral health, such as Haemophilus, Granulicatella, and Abiotrophia, showed an increase after administering the antibiotic. In conclusion, periodontitis exacerbations as a direct manifestation of systemic disease can occasionally be controlled exclusively with systemic antibiotics, without the need for performing mechanical periodontal therapy. This clinical recovery is correlated to substantial changes in the oral microbiome, which lead to the recovery of eubiosis of the microbiota. MDPI 2022-12-04 /pmc/articles/PMC9774349/ /pubmed/36551411 http://dx.doi.org/10.3390/antibiotics11121754 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Muñoz Navarro, Carolina
del Carmen Sánchez Beltrán, María
Arriagada Vargas, Carolina
Batalla Vázquez, Pilar
Diniz Freitas, Márcio
Limeres Posse, Jacobo
Diz Dios, Pedro
García Mato, Eliane
Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy
title Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy
title_full Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy
title_fullStr Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy
title_full_unstemmed Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy
title_short Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy
title_sort analysis of the oral microbiome in a patient with cardiofaciocutaneous syndrome and severe periodontal disease: impact of systemic antibiotic therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774349/
https://www.ncbi.nlm.nih.gov/pubmed/36551411
http://dx.doi.org/10.3390/antibiotics11121754
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