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COSUTI: A Core Outcome Set (COS) for Interventions for the Treatment of Uncomplicated Urinary Tract Infection (UTI) in Adults

Background: Uncomplicated urinary tract infections (UTIs) are among the most common presentations of bacterial infections in the outpatient setting. The variation of outcomes reported in trials to assess the most effective treatment interventions for uncomplicated UTIs has meant that comparing and s...

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Autores principales: Beecher, Claire, Duane, Sinead, Vellinga, Akke, Murphy, Andrew W., Cormican, Martin, Smyth, Andrew, Healy, Patricia, Moore, Michael, Little, Paul, Geoghegan, Carmel, Devane, Declan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774367/
https://www.ncbi.nlm.nih.gov/pubmed/36551503
http://dx.doi.org/10.3390/antibiotics11121846
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author Beecher, Claire
Duane, Sinead
Vellinga, Akke
Murphy, Andrew W.
Cormican, Martin
Smyth, Andrew
Healy, Patricia
Moore, Michael
Little, Paul
Geoghegan, Carmel
Devane, Declan
author_facet Beecher, Claire
Duane, Sinead
Vellinga, Akke
Murphy, Andrew W.
Cormican, Martin
Smyth, Andrew
Healy, Patricia
Moore, Michael
Little, Paul
Geoghegan, Carmel
Devane, Declan
author_sort Beecher, Claire
collection PubMed
description Background: Uncomplicated urinary tract infections (UTIs) are among the most common presentations of bacterial infections in the outpatient setting. The variation of outcomes reported in trials to assess the most effective treatment interventions for uncomplicated UTIs has meant that comparing and synthesising the outcomes across trials is challenging and limits the reliability of evidence which would otherwise inform healthcare decisions. Objective: Develop a Core Outcome Set (COS) for interventions for the treatment of uncomplicated UTIs in otherwise healthy adults. Methods: The COS development consisted of three phases: (1) A systematic review to identify outcomes reported in randomised trials and systematic reviews of randomised trials comparing the effectiveness of any interventions for the treatment of uncomplicated UTI in otherwise healthy adults; (2) Outcomes identified in the systematic review were prioritised in an online 3-round modified Delphi survey with healthcare practitioners (n = 68), researchers (n = 5), and people who have experienced or cared for someone experiencing a UTI (n = 180); (3) An online consensus meeting to determine the final COS with healthcare practitioners and policymakers (n = 9), researchers (n = 4), and people who have experienced or cared for someone experiencing a UTI (n = 7). Results: We identified a large number of outcomes. Through the use of robust consensus methods, those outcomes were reduced to a core set of six outcomes that should, at a minimum, be measured and reported in randomised trials and systematic reviews of interventions treating uncomplicated UTIs in adults.
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spelling pubmed-97743672022-12-23 COSUTI: A Core Outcome Set (COS) for Interventions for the Treatment of Uncomplicated Urinary Tract Infection (UTI) in Adults Beecher, Claire Duane, Sinead Vellinga, Akke Murphy, Andrew W. Cormican, Martin Smyth, Andrew Healy, Patricia Moore, Michael Little, Paul Geoghegan, Carmel Devane, Declan Antibiotics (Basel) Article Background: Uncomplicated urinary tract infections (UTIs) are among the most common presentations of bacterial infections in the outpatient setting. The variation of outcomes reported in trials to assess the most effective treatment interventions for uncomplicated UTIs has meant that comparing and synthesising the outcomes across trials is challenging and limits the reliability of evidence which would otherwise inform healthcare decisions. Objective: Develop a Core Outcome Set (COS) for interventions for the treatment of uncomplicated UTIs in otherwise healthy adults. Methods: The COS development consisted of three phases: (1) A systematic review to identify outcomes reported in randomised trials and systematic reviews of randomised trials comparing the effectiveness of any interventions for the treatment of uncomplicated UTI in otherwise healthy adults; (2) Outcomes identified in the systematic review were prioritised in an online 3-round modified Delphi survey with healthcare practitioners (n = 68), researchers (n = 5), and people who have experienced or cared for someone experiencing a UTI (n = 180); (3) An online consensus meeting to determine the final COS with healthcare practitioners and policymakers (n = 9), researchers (n = 4), and people who have experienced or cared for someone experiencing a UTI (n = 7). Results: We identified a large number of outcomes. Through the use of robust consensus methods, those outcomes were reduced to a core set of six outcomes that should, at a minimum, be measured and reported in randomised trials and systematic reviews of interventions treating uncomplicated UTIs in adults. MDPI 2022-12-19 /pmc/articles/PMC9774367/ /pubmed/36551503 http://dx.doi.org/10.3390/antibiotics11121846 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Beecher, Claire
Duane, Sinead
Vellinga, Akke
Murphy, Andrew W.
Cormican, Martin
Smyth, Andrew
Healy, Patricia
Moore, Michael
Little, Paul
Geoghegan, Carmel
Devane, Declan
COSUTI: A Core Outcome Set (COS) for Interventions for the Treatment of Uncomplicated Urinary Tract Infection (UTI) in Adults
title COSUTI: A Core Outcome Set (COS) for Interventions for the Treatment of Uncomplicated Urinary Tract Infection (UTI) in Adults
title_full COSUTI: A Core Outcome Set (COS) for Interventions for the Treatment of Uncomplicated Urinary Tract Infection (UTI) in Adults
title_fullStr COSUTI: A Core Outcome Set (COS) for Interventions for the Treatment of Uncomplicated Urinary Tract Infection (UTI) in Adults
title_full_unstemmed COSUTI: A Core Outcome Set (COS) for Interventions for the Treatment of Uncomplicated Urinary Tract Infection (UTI) in Adults
title_short COSUTI: A Core Outcome Set (COS) for Interventions for the Treatment of Uncomplicated Urinary Tract Infection (UTI) in Adults
title_sort cosuti: a core outcome set (cos) for interventions for the treatment of uncomplicated urinary tract infection (uti) in adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774367/
https://www.ncbi.nlm.nih.gov/pubmed/36551503
http://dx.doi.org/10.3390/antibiotics11121846
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