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Effects of Bismuth Exposure on the Human Kidney—A Systematic Review

The effects of bismuth toxicity on the kidney—the main organ responsible for blood filtration—were systematically reviewed. This review was motivated by availability of several sources of bismuth in contact with humans including environmental, medications, dental materials, and cosmetics, potentiall...

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Autores principales: Pelepenko, Lauter E., Janini, Ana Cristina P., Gomes, Brenda P. F. A., de-Jesus-Soares, Adriana, Marciano, Marina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774474/
https://www.ncbi.nlm.nih.gov/pubmed/36551397
http://dx.doi.org/10.3390/antibiotics11121741
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author Pelepenko, Lauter E.
Janini, Ana Cristina P.
Gomes, Brenda P. F. A.
de-Jesus-Soares, Adriana
Marciano, Marina A.
author_facet Pelepenko, Lauter E.
Janini, Ana Cristina P.
Gomes, Brenda P. F. A.
de-Jesus-Soares, Adriana
Marciano, Marina A.
author_sort Pelepenko, Lauter E.
collection PubMed
description The effects of bismuth toxicity on the kidney—the main organ responsible for blood filtration—were systematically reviewed. This review was motivated by availability of several sources of bismuth in contact with humans including environmental, medications, dental materials, and cosmetics, potentially leading to kidney filtration of this chemical. No previous studies have systematically reviewed the literature considering this association. A total of 22 studies with a total of 46 individuals met the inclusion criteria, 19 being case reports with only one patient enrolled. The included studies publication dates ranged from 1961 to 2021 and the countries of publication were the United States of America, United Kingdom, Germany, Turkey, Switzerland, and Canada. Bismuth sources affecting the kidneys were uniquely reported as from medical purposes and mostly associated to overdoses with several symptoms, apparently with dose-dependent consequences. Patient history of renal impairment seemed to affect the outcome of the case. Several therapies were conducted following bismuth intoxication, and few studies performed renal biopsies describing its histological findings. It is crucial to reconsider the nephrotoxicity of bismuth compounds, mainly in patients with previous history of renal impairment.
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spelling pubmed-97744742022-12-23 Effects of Bismuth Exposure on the Human Kidney—A Systematic Review Pelepenko, Lauter E. Janini, Ana Cristina P. Gomes, Brenda P. F. A. de-Jesus-Soares, Adriana Marciano, Marina A. Antibiotics (Basel) Systematic Review The effects of bismuth toxicity on the kidney—the main organ responsible for blood filtration—were systematically reviewed. This review was motivated by availability of several sources of bismuth in contact with humans including environmental, medications, dental materials, and cosmetics, potentially leading to kidney filtration of this chemical. No previous studies have systematically reviewed the literature considering this association. A total of 22 studies with a total of 46 individuals met the inclusion criteria, 19 being case reports with only one patient enrolled. The included studies publication dates ranged from 1961 to 2021 and the countries of publication were the United States of America, United Kingdom, Germany, Turkey, Switzerland, and Canada. Bismuth sources affecting the kidneys were uniquely reported as from medical purposes and mostly associated to overdoses with several symptoms, apparently with dose-dependent consequences. Patient history of renal impairment seemed to affect the outcome of the case. Several therapies were conducted following bismuth intoxication, and few studies performed renal biopsies describing its histological findings. It is crucial to reconsider the nephrotoxicity of bismuth compounds, mainly in patients with previous history of renal impairment. MDPI 2022-12-02 /pmc/articles/PMC9774474/ /pubmed/36551397 http://dx.doi.org/10.3390/antibiotics11121741 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Pelepenko, Lauter E.
Janini, Ana Cristina P.
Gomes, Brenda P. F. A.
de-Jesus-Soares, Adriana
Marciano, Marina A.
Effects of Bismuth Exposure on the Human Kidney—A Systematic Review
title Effects of Bismuth Exposure on the Human Kidney—A Systematic Review
title_full Effects of Bismuth Exposure on the Human Kidney—A Systematic Review
title_fullStr Effects of Bismuth Exposure on the Human Kidney—A Systematic Review
title_full_unstemmed Effects of Bismuth Exposure on the Human Kidney—A Systematic Review
title_short Effects of Bismuth Exposure on the Human Kidney—A Systematic Review
title_sort effects of bismuth exposure on the human kidney—a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774474/
https://www.ncbi.nlm.nih.gov/pubmed/36551397
http://dx.doi.org/10.3390/antibiotics11121741
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