The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities

INTRODUCTION: Critical steps in Major Histocompatibility Complex Class I (MHC-I) antigen presentation occur in the endoplasmic reticulum (ER). In general, peptides that enter the ER are longer than the optimal length for MHC-I binding. The final trimming of MHC-I epitopes is performed by two related...

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Detalles Bibliográficos
Autores principales: Martín-Esteban, Adrian, Rodriguez, Jesus Contreras, Peske, David, Lopez de Castro, Jose A., Shastri, Nilabh, Sadegh-Nasseri, Scheherazade
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774488/
https://www.ncbi.nlm.nih.gov/pubmed/36569828
http://dx.doi.org/10.3389/fimmu.2022.1066483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774488/
https://www.ncbi.nlm.nih.gov/pubmed/36569828
http://dx.doi.org/10.3389/fimmu.2022.1066483

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