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The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities
INTRODUCTION: Critical steps in Major Histocompatibility Complex Class I (MHC-I) antigen presentation occur in the endoplasmic reticulum (ER). In general, peptides that enter the ER are longer than the optimal length for MHC-I binding. The final trimming of MHC-I epitopes is performed by two related...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774488/ https://www.ncbi.nlm.nih.gov/pubmed/36569828 http://dx.doi.org/10.3389/fimmu.2022.1066483 |