Discovery of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases in Diverse Environmental Settings Suggests an Evolutionary Advantage Unrelated to Antibiotic Resistance

Type B dihydrofolate reductases (DfrB) are intrinsically highly resistant to the widely used antibiotic trimethoprim, posing a threat to global public health. The ten known DfrB family members have been strongly associated with genetic material related to the application of antibiotics. Several dfrB...

Descripción completa

Detalles Bibliográficos
Autores principales: Cellier-Goetghebeur, Stella, Lafontaine, Kiana, Lemay-St-Denis, Claudèle, Tsamo, Princesse, Bonneau-Burke, Alexis, Copp, Janine N., Pelletier, Joelle N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774602/
https://www.ncbi.nlm.nih.gov/pubmed/36551425
http://dx.doi.org/10.3390/antibiotics11121768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774602/
https://www.ncbi.nlm.nih.gov/pubmed/36551425
http://dx.doi.org/10.3390/antibiotics11121768

Ejemplares similares