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Discovery of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases in Diverse Environmental Settings Suggests an Evolutionary Advantage Unrelated to Antibiotic Resistance

Type B dihydrofolate reductases (DfrB) are intrinsically highly resistant to the widely used antibiotic trimethoprim, posing a threat to global public health. The ten known DfrB family members have been strongly associated with genetic material related to the application of antibiotics. Several dfrB...

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Detalles Bibliográficos
Autores principales:	Cellier-Goetghebeur, Stella, Lafontaine, Kiana, Lemay-St-Denis, Claudèle, Tsamo, Princesse, Bonneau-Burke, Alexis, Copp, Janine N., Pelletier, Joelle N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774602/ https://www.ncbi.nlm.nih.gov/pubmed/36551425 http://dx.doi.org/10.3390/antibiotics11121768

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