The Role of Heme Oxygenase-1 as an Immunomodulator in Kidney Disease

The protein heme oxygenase (HO)-1 has been implicated in the regulations of multiple immunological processes. It is well known that kidney injury is affected by immune mechanisms and that various kidney-disease forms may be a result of autoimmune disease. The current study describes in detail the ro...

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Autores principales: Athanassiadou, Virginia, Plavoukou, Stella, Grapsa, Eirini, Detsika, Maria G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774641/
https://www.ncbi.nlm.nih.gov/pubmed/36552662
http://dx.doi.org/10.3390/antiox11122454
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author Athanassiadou, Virginia
Plavoukou, Stella
Grapsa, Eirini
Detsika, Maria G.
author_facet Athanassiadou, Virginia
Plavoukou, Stella
Grapsa, Eirini
Detsika, Maria G.
author_sort Athanassiadou, Virginia
collection PubMed
description The protein heme oxygenase (HO)-1 has been implicated in the regulations of multiple immunological processes. It is well known that kidney injury is affected by immune mechanisms and that various kidney-disease forms may be a result of autoimmune disease. The current study describes in detail the role of HO-1 in kidney disease and provides the most recent observations of the effect of HO-1 on immune pathways and responses both in animal models of immune-mediated disease forms and in patient studies.
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spelling pubmed-97746412022-12-23 The Role of Heme Oxygenase-1 as an Immunomodulator in Kidney Disease Athanassiadou, Virginia Plavoukou, Stella Grapsa, Eirini Detsika, Maria G. Antioxidants (Basel) Review The protein heme oxygenase (HO)-1 has been implicated in the regulations of multiple immunological processes. It is well known that kidney injury is affected by immune mechanisms and that various kidney-disease forms may be a result of autoimmune disease. The current study describes in detail the role of HO-1 in kidney disease and provides the most recent observations of the effect of HO-1 on immune pathways and responses both in animal models of immune-mediated disease forms and in patient studies. MDPI 2022-12-13 /pmc/articles/PMC9774641/ /pubmed/36552662 http://dx.doi.org/10.3390/antiox11122454 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Athanassiadou, Virginia
Plavoukou, Stella
Grapsa, Eirini
Detsika, Maria G.
The Role of Heme Oxygenase-1 as an Immunomodulator in Kidney Disease
title The Role of Heme Oxygenase-1 as an Immunomodulator in Kidney Disease
title_full The Role of Heme Oxygenase-1 as an Immunomodulator in Kidney Disease
title_fullStr The Role of Heme Oxygenase-1 as an Immunomodulator in Kidney Disease
title_full_unstemmed The Role of Heme Oxygenase-1 as an Immunomodulator in Kidney Disease
title_short The Role of Heme Oxygenase-1 as an Immunomodulator in Kidney Disease
title_sort role of heme oxygenase-1 as an immunomodulator in kidney disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774641/
https://www.ncbi.nlm.nih.gov/pubmed/36552662
http://dx.doi.org/10.3390/antiox11122454
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