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Studies Regarding the Antimicrobial Behavior of Clotrimazole and Limonene

The paper presents the results of the studies performed to establish the effect of the mixtures between limonene and clotrimazole against microbial pathogens involved in dermatological diseases, such as Candida albicans, Staphyloccocus aureus, and Escherichia coli. Preliminary data obtained from the...

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Autores principales: Schroder, Verginica, Radu, Nicoleta, Cornea, Petruta Calina, Coman, Oana Andreia, Pirvu, Lucia Camelia, Mohammed, Mohammed Shaymaa Omar, Stefaniu, Amalia, Pintilie, Lucia, Bostan, Marinela, Caramihai, Mihai Dan, Roman, Viviana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774930/
https://www.ncbi.nlm.nih.gov/pubmed/36551473
http://dx.doi.org/10.3390/antibiotics11121816
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author Schroder, Verginica
Radu, Nicoleta
Cornea, Petruta Calina
Coman, Oana Andreia
Pirvu, Lucia Camelia
Mohammed, Mohammed Shaymaa Omar
Stefaniu, Amalia
Pintilie, Lucia
Bostan, Marinela
Caramihai, Mihai Dan
Roman, Viviana
author_facet Schroder, Verginica
Radu, Nicoleta
Cornea, Petruta Calina
Coman, Oana Andreia
Pirvu, Lucia Camelia
Mohammed, Mohammed Shaymaa Omar
Stefaniu, Amalia
Pintilie, Lucia
Bostan, Marinela
Caramihai, Mihai Dan
Roman, Viviana
author_sort Schroder, Verginica
collection PubMed
description The paper presents the results of the studies performed to establish the effect of the mixtures between limonene and clotrimazole against microbial pathogens involved in dermatological diseases, such as Candida albicans, Staphyloccocus aureus, and Escherichia coli. Preliminary data obtained from the studies performed in microplates revealed a possible synergism between the mixture of clotrimazole and limonene for Staphylococcus aureus. Studies performed “in silico” with programs such as CLC Drug Discovery Workbench and MOLEGRO Virtual Docker, gave favorable scores for docking each compound on a specific binding site for each microorganism. The tests performed for validation, with the clotrimazole (0.1%) and different sources of limonene (1.9% citrus essential oils), showed a synergistic effect on Staphylococcus aureus in the case of the mixtures between clotrimazole and the essential oils of Citrus reticulata or Citrus paradisi. The studies performed on Staphylococcus aureus MRSA showed a synergistic effect between clotrimazole and the essential oils obtained from Citrus bergamia, Citrus aurantium, or Citrus paradisi. In the case of Pseudomonas aeruginosa, essential oils and clotrimazole used alone did not exhibit antimicrobial activities, but the mixtures between clotrimazole and the essential oils of Citrus bergamia or Citrus sinensis exhibited a synergistic antimicrobial effect.
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spelling pubmed-97749302022-12-23 Studies Regarding the Antimicrobial Behavior of Clotrimazole and Limonene Schroder, Verginica Radu, Nicoleta Cornea, Petruta Calina Coman, Oana Andreia Pirvu, Lucia Camelia Mohammed, Mohammed Shaymaa Omar Stefaniu, Amalia Pintilie, Lucia Bostan, Marinela Caramihai, Mihai Dan Roman, Viviana Antibiotics (Basel) Article The paper presents the results of the studies performed to establish the effect of the mixtures between limonene and clotrimazole against microbial pathogens involved in dermatological diseases, such as Candida albicans, Staphyloccocus aureus, and Escherichia coli. Preliminary data obtained from the studies performed in microplates revealed a possible synergism between the mixture of clotrimazole and limonene for Staphylococcus aureus. Studies performed “in silico” with programs such as CLC Drug Discovery Workbench and MOLEGRO Virtual Docker, gave favorable scores for docking each compound on a specific binding site for each microorganism. The tests performed for validation, with the clotrimazole (0.1%) and different sources of limonene (1.9% citrus essential oils), showed a synergistic effect on Staphylococcus aureus in the case of the mixtures between clotrimazole and the essential oils of Citrus reticulata or Citrus paradisi. The studies performed on Staphylococcus aureus MRSA showed a synergistic effect between clotrimazole and the essential oils obtained from Citrus bergamia, Citrus aurantium, or Citrus paradisi. In the case of Pseudomonas aeruginosa, essential oils and clotrimazole used alone did not exhibit antimicrobial activities, but the mixtures between clotrimazole and the essential oils of Citrus bergamia or Citrus sinensis exhibited a synergistic antimicrobial effect. MDPI 2022-12-14 /pmc/articles/PMC9774930/ /pubmed/36551473 http://dx.doi.org/10.3390/antibiotics11121816 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schroder, Verginica
Radu, Nicoleta
Cornea, Petruta Calina
Coman, Oana Andreia
Pirvu, Lucia Camelia
Mohammed, Mohammed Shaymaa Omar
Stefaniu, Amalia
Pintilie, Lucia
Bostan, Marinela
Caramihai, Mihai Dan
Roman, Viviana
Studies Regarding the Antimicrobial Behavior of Clotrimazole and Limonene
title Studies Regarding the Antimicrobial Behavior of Clotrimazole and Limonene
title_full Studies Regarding the Antimicrobial Behavior of Clotrimazole and Limonene
title_fullStr Studies Regarding the Antimicrobial Behavior of Clotrimazole and Limonene
title_full_unstemmed Studies Regarding the Antimicrobial Behavior of Clotrimazole and Limonene
title_short Studies Regarding the Antimicrobial Behavior of Clotrimazole and Limonene
title_sort studies regarding the antimicrobial behavior of clotrimazole and limonene
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774930/
https://www.ncbi.nlm.nih.gov/pubmed/36551473
http://dx.doi.org/10.3390/antibiotics11121816
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